Curtis Jamison Perry, MD, PhD
Instructor of Medicine (Medical Oncology & Hematology)About
Research
Publications
2025
Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition
Leitner B, Fosam A, Lee W, Zilinger K, Nakandakari S, Zhang X, Gaspar R, Zhu W, Perry C, Rabinowitz J, Perry R. Precancer exercise capacity and metabolism during tumor development coordinate the skeletal muscle–tumor metabolic competition. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2508707122. PMID: 41325517, PMCID: PMC12704748, DOI: 10.1073/pnas.2508707122.Peer-Reviewed Original ResearchConceptsExercise trainingExercise capacityAerobic exercise trainingRegular exercise trainingHigher exercise capacityMuscle glucose metabolismVoluntary wheel runningTumor progressionGlucose metabolismVoluntary exerciseCardiac muscleExerciseTumor glucose metabolismTumor-host interactionsMetabolic competitionStage of diseaseMuscleCancer prognosisSystemic glucose metabolismTumor energeticsTumor microenvironmentMelanoma tumorsTumor growthTumor developmentTrainingInteractions among tumor subtype, PPARγ expression, and adipose proliferation shape outcomes in breast cancer
Shah A, Liu K, Liu R, Ramshankar G, Perry C, Perry R. Interactions among tumor subtype, PPARγ expression, and adipose proliferation shape outcomes in breast cancer. Physiological Reports 2025, 13: e70649. PMID: 41236441, PMCID: PMC12617248, DOI: 10.14814/phy2.70649.Peer-Reviewed Original ResearchConceptsStandardized uptake valueBreast cancer patientsTumor subtypesMenopausal statusPrognostic relevanceBreast cancerCancer patientsPrimary breast cancer patientsPPARG expressionPET-CT scanKaplan-Meier analysisTumor receptor subtypeAdipose tissueNon-TNBC tumorsAdipose tissue proliferationTCGA-BRCA cohortBreast cancer progressionPostmenopausal patientsPremenopausal patientsPrecision medicine treatmentsOverall survivalPET-CTSubcutaneous adipose tissueUptake valueReceptor subtypes907 Midkine suppresses interferon-driven antigen presentation and dendritic-cell activation in neuroendocrine tumors
Wang J, Perry C, Frey A, Fei Y, Costa P, Ghadermarzi S, Levine D, Ishizuka J. 907 Midkine suppresses interferon-driven antigen presentation and dendritic-cell activation in neuroendocrine tumors. 2025, a1027-a1027. DOI: 10.1136/jitc-2025-sitc2025.0907.Peer-Reviewed Original ResearchMolecular Characterization of Polyomavirus-Positive and Negative Merkel Cell Carcinoma
Vaidya P, Wu S, Bryant D, Perry C, Prakash V, Lou E, Guo T, Brownell I, Darabi S, Gao L, Abdulla F, Park S. Molecular Characterization of Polyomavirus-Positive and Negative Merkel Cell Carcinoma. Cancers 2025, 17: 3508. PMID: 41228301, PMCID: PMC12609552, DOI: 10.3390/cancers17213508.Peer-Reviewed Original ResearchImmune checkpoint inhibitorsMerkel cell carcinomaTumor mutational burdenWhole-exome sequencingMerkel cell carcinoma casesVN-MCCViral statusNOTCH1TP53Genomic alterationsAssociated with ICI responseMedian tumor mutation burdenAdvanced Merkel cell carcinomaNK cell infiltrationMCC oncogenesisTherapeutic targetCheckpoint inhibitorsPathway activity scoresICI responseImmune microenvironmentCell carcinomaMutational burdenTumor microenvironmentFrontline treatmentTreatment responseTargeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma
Frey A, Clulo K, Fei Y, Dumit T, Scallo F, Allen J, Chang E, Perry C, Wirth L, Jacobs D, Braun D, Bosenberg M, Tran T, Clune J, Kluger H, Olino K, Ishizuka J. Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma. Cell Reports 2025, 44: 116359. PMID: 41042672, PMCID: PMC12646823, DOI: 10.1016/j.celrep.2025.116359.Peer-Reviewed Original ResearchMerkel cell carcinomaMRNA vaccinesCell carcinomaCD8+ T cell memoryAntigen-specific T cell expansionTumor cell expressionT cell expansionT cell memoryTumor cell survivalTumor controlMemory differentiationAntigen lossResponse durabilityMurine studiesAntigen exposureIL-7Mouse modelOptimal vaccine targetsCell expressionMRNA technologyPatient samplesMRNA therapeuticsStrong antigensTumorViral oncoproteinsTranscriptomic landscape of Kaposi sarcoma: Insights into therapeutic targeting of KSHV.
Fei Y, Costa P, Junejo M, Li M, Perry C, Damsky W, Ishizuka J. Transcriptomic landscape of Kaposi sarcoma: Insights into therapeutic targeting of KSHV. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e23526.Peer-Reviewed Original ResearchKaposi's sarcoma herpesvirusKaposi's sarcomaTranscripts Per MillionKSHV genomeHIV statusPresence of Kaposi’s sarcoma herpesvirusDisease progressionLatency-associated regionExpressed genesHistory of organ transplantationVirus-associated tumorsTherapeutic targetFormalin-fixed paraffin-embedded (FFPEGene expressionParaffin-embedded (FFPEHuman herpesvirus 8Differential gene expression analysisDisseminated diseaseViral eradicationViral gene expressionHIV-positiveBaseline characteristicsHHV-8Gene expression analysisTumor morphologyPerturbational single-cell RNA sequencing of patient tumors in Merkel cell and small cell lung carcinomas.
Perry C, Frey A, Fei Y, Costa P, Wang J, Ghadermarzi S, Levine D, Koda A, Nassar A, Ding M, Nie Y, Cordero-Dumit T, Augert A, van Djik D, Olino K, Ishizuka J. Perturbational single-cell RNA sequencing of patient tumors in Merkel cell and small cell lung carcinomas. Journal Of Clinical Oncology 2025, 43: 2520-2520. DOI: 10.1200/jco.2025.43.16_suppl.2520.Peer-Reviewed Original ResearchSmall cell lung cancerMerkel cell carcinomaMonocyte-derived DCCD14+ monocytesT cellsPatient tumorsResponse to IFNImpact of immune checkpoint blockadeTumor-infiltrating T cellsCo-CultureSmall cell lung carcinomaTumor immunity cycleImmune checkpoint blockadeImmune cells co-culturedCell lung carcinomaInnate immune signaturesHuman tumor specimensCell lung cancerLymph node metastasisCell linesFactors associated with responseLong-term survivalAssociated with nonresponseStandard of careImmune samples
2023
Clinical Predictors of Survival in Patients With BRAFV600-Mutated Metastatic Melanoma Treated With Combined BRAF and MEK Inhibitors After Immune Checkpoint Inhibitors
Kahn A, Perry C, Etts K, Kluger H, Sznol M. Clinical Predictors of Survival in Patients With BRAFV600-Mutated Metastatic Melanoma Treated With Combined BRAF and MEK Inhibitors After Immune Checkpoint Inhibitors. The Oncologist 2023, 29: e507-e513. PMID: 37971411, PMCID: PMC10994263, DOI: 10.1093/oncolo/oyad300.Peer-Reviewed Original ResearchBRAF/MEK inhibitorsBRAF/MEK inhibitionImmune checkpoint inhibitorsBRAFV600E/K mutationsMEK inhibitorsCheckpoint inhibitorsClinical variablesMEK inhibitionRetrospective single-institution analysisIpilimumab/nivolumabFirst-line settingFirst-line therapyFirst-line treatmentMetastatic melanoma patientsLong-term outcomesPretreatment clinical variablesSingle-institution analysisStratification of patientsK mutationCombined BRAFECOG PSMedian OSRECIST 1.1Immunotherapy regimenClinical characteristicsCausal identification of single-cell experimental perturbation effects with CINEMA-OT
Dong M, Wang B, Wei J, de O. Fonseca A, Perry C, Frey A, Ouerghi F, Foxman E, Ishizuka J, Dhodapkar R, van Dijk D. Causal identification of single-cell experimental perturbation effects with CINEMA-OT. Nature Methods 2023, 20: 1769-1779. PMID: 37919419, PMCID: PMC10630139, DOI: 10.1038/s41592-023-02040-5.Peer-Reviewed Original Research
2022
Clinical predictors of longer survival in patients with BRAFV600-mutated metastatic melanoma receiving immunotherapy prior to BRAF/MEK inhibition in the metastatic setting.
Kahn A, Perry C, Etts K, Kluger H, Sznol M. Clinical predictors of longer survival in patients with BRAFV600-mutated metastatic melanoma receiving immunotherapy prior to BRAF/MEK inhibition in the metastatic setting. Journal Of Clinical Oncology 2022, 40: 9555-9555. DOI: 10.1200/jco.2022.40.16_suppl.9555.Peer-Reviewed Original ResearchBRAF/MEKiFirst-line immunotherapyBRAF/MEK inhibitionBRAF V600Metastatic melanomaLonger survivalAdverse eventsMedian durationMost patientsBone metastasesClinical predictorsDisease progressionMEK inhibitionAdvanced BRAF V600ECOG PS 0Median ECOG PSFirst-line settingKaplan-Meier methodMost common sitePredictors of survivalECOG PSMedian LDHData cutoffMetastatic settingMedian survival
Academic Achievements & Community Involvement
Clinical Care
Overview
Clinical Specialties
Genitourinary Oncology; Medical Oncology; Urologic Oncology
Board Certifications
Medical Oncology
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2024
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2021
News & Links
News
- January 12, 2026
How Exercise Slows Tumor Growth
- October 28, 2025
Yale Develops Dual-Action Vaccine to Combat Aggressive Merkel Cell Carcinoma
- June 06, 2025
Yale Cancer Center Researchers and Trainees Present at 2025 ASCO Annual Meeting
- May 14, 2025
Yale Cancer Center Experts Set to Present Advances in Cancer Research at the World’s Largest Clinical Oncology Conference
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CMCO
Lab
300 George Street, Fl 6
New Haven, CT 06511
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