Chengye Feng
Associate Research Scientist in GeneticsDownloadHi-Res Photo
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Associate Research Scientist in Genetics
Departments & Organizations
Education & Training
- PhD
- Pennsylvania State University, MCIBS
- BS
- Nankai Univeristy
Research
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Overview
I am interested in the cell biology of neurons during development and regeneration. My earlier work asked how microtubule organization is established and maintained in dendrites, during both development and regeneration. Currently I work on improving functional recovery after axon injury, using endogenous protein tagging, single-cell imaging, laser axotomy and optogenetics in C. elegans.
ORCID
0000-0001-7330-4273
Research at a Glance
Yale Co-Authors
Frequent collaborators of Chengye Feng's published research.
Publications Timeline
A big-picture view of Chengye Feng's research output by year.
Marc Hammarlund, PhD
10Publications
313Citations
Publications
Featured Publications
Patronin-mediated minus end growth is required for dendritic microtubule polarity
Feng C, Thyagarajan P, Shorey M, Seebold D, Weiner A, Albertson R, Rao K, Sagasti A, Goetschius D, Rolls M. Patronin-mediated minus end growth is required for dendritic microtubule polarity. Journal Of Cell Biology 2019, 218: 2309-2328. PMID: 31076454, PMCID: PMC6605808, DOI: 10.1083/jcb.201810155.Peer-Reviewed Original ResearchCitationsAltmetric
2026
Patronin promotes formation of dynamic microtubule seeds in vivo
Shen Y, Weiner A, Thyagarajan P, Feng C, Rolls M. Patronin promotes formation of dynamic microtubule seeds in vivo. Journal Of Cell Science 2026, 139: jcs264778. PMID: 42253036, PMCID: PMC13384428, DOI: 10.1242/jcs.264778.Peer-Reviewed Original ResearchAltmetric
2023
Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans
Khazma T, Grossman A, Guez-Haddad J, Feng C, Dabas H, Sain R, Weitman M, Zalk R, Isupov M, Hammarlund M, Hons M, Opatowsky Y. Structure-function analysis of ceTIR-1/hSARM1 explains the lack of Wallerian axonal degeneration in C. elegans. Cell Reports 2023, 42: 113026. PMID: 37635352, PMCID: PMC10675840, DOI: 10.1016/j.celrep.2023.113026.Peer-Reviewed Original ResearchCitationsAltmetric
2022
Microtubule polarity is instructive for many aspects of neuronal polarity
Thyagarajan P, Feng C, Lee D, Shorey M, Rolls M. Microtubule polarity is instructive for many aspects of neuronal polarity. Developmental Biology 2022, 486: 56-70. PMID: 35341730, PMCID: PMC9058238, DOI: 10.1016/j.ydbio.2022.03.009.Peer-Reviewed Original ResearchCitationsAltmetric
2021
Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules
Feng C, Cleary J, Kothe G, Stone M, Weiner A, Hertzler J, Hancock W, Rolls M. Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules. Journal Of Cell Science 2021, 134 PMID: 34096607, PMCID: PMC8214762, DOI: 10.1242/jcs.258437.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Microtubule dynamics in healthy and injured neurons
Rolls M, Thyagarajan P, Feng C. Microtubule dynamics in healthy and injured neurons. Developmental Neurobiology 2020, 81: 321-332. PMID: 32291942, PMCID: PMC7572564, DOI: 10.1002/dneu.22746.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetricMeSH Keywords
2018
Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites
Weiner A, Seebold D, Michael N, Guignet M, Feng C, Follick B, Yusko B, Wasilko N, Torres-Gutierrez P, Rolls M. Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites. G3: Genes, Genomes, Genetics 2018, 8: 1841-1853. PMID: 29602811, PMCID: PMC5940173, DOI: 10.1534/g3.118.200205.Peer-Reviewed Original ResearchCitationsAltmetric
2016
Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment
Jegla T, Nguyen M, Feng C, Goetschius D, Luna E, van Rossum D, Kamel B, Pisupati A, Milner E, Rolls M. Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. PLOS Genetics 2016, 12: e1006457. PMID: 27911898, PMCID: PMC5135030, DOI: 10.1371/journal.pgen.1006457.Peer-Reviewed Original ResearchCitationsAltmetricThe microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration
Tao J, Feng C, Rolls M. The microtubule-severing protein fidgetin acts after dendrite injury to promote their degeneration. Journal Of Cell Science 2016, 129: 3274-3281. PMID: 27411367, PMCID: PMC5047702, DOI: 10.1242/jcs.188540.Peer-Reviewed Original ResearchCitations
2013
Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity
He M, Zhang L, Wang X, Huo L, Sun L, Feng C, Jing X, Du D, Liang H, Liu M, Hong Z, Zhou J. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. PLOS ONE 2013, 8: e67186. PMID: 23826228, PMCID: PMC3695041, DOI: 10.1371/journal.pone.0067186.Peer-Reviewed Original ResearchCitations
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New Haven, CT 06510