Benjamin Landis, MD
Cards
About
Research
Publications
2025
Combined genome and transcriptome analysis identifies molecular signatures of aortic disease in patients with Marfan syndrome
Stanley K, Mederos A, Barksdale E, Corvera J, Davis J, Fang F, Gao H, Vujakovich C, Liu Y, Ware S, Landis B. Combined genome and transcriptome analysis identifies molecular signatures of aortic disease in patients with Marfan syndrome. Journal Of Molecular And Cellular Cardiology Plus 2025, 13: 100467. PMID: 40678173, PMCID: PMC12269431, DOI: 10.1016/j.jmccpl.2025.100467.Peer-Reviewed Original ResearchSINGLE-CELL FIXED RNA GENE EXPRESSION PROFILING IN HUMAN THORACIC AORTOPATHY
Barksdale E, Gao H, Fang F, Vujakovich C, Corvera J, Landis B. SINGLE-CELL FIXED RNA GENE EXPRESSION PROFILING IN HUMAN THORACIC AORTOPATHY. Journal Of The American College Of Cardiology 2025, 85: 2381. DOI: 10.1016/s0735-1097(25)02865-7.Peer-Reviewed Original ResearchDysmorphology-Based Prediction Model for Genetic Disorders in Infants With Congenital Heart Disease
Helm B, Wetherill L, Landis B, Ware S. Dysmorphology-Based Prediction Model for Genetic Disorders in Infants With Congenital Heart Disease. Circulation Genomic And Precision Medicine 2025, 18: e004895. PMID: 40151936, PMCID: PMC11999770, DOI: 10.1161/circgen.124.004895.Peer-Reviewed Original ResearchIdentification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease
Penaloza J, Moreland B, Gaither J, Landis B, Ware S, McBride K, White P, Helvaty L, Geddes G, Hodge J, Garg V, Lo C, Yatsenko S, Lin J, Wechsler S, Lalani S. Identification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease. Journal Of The American Heart Association 2025, 14: e039177. PMID: 40079339, PMCID: PMC12132622, DOI: 10.1161/jaha.124.039177.Peer-Reviewed Original Research
2024
Performance of Dysmorphology‐Based Screening for Genetic Disorders in Pediatric Congenital Heart Disease Supports Wider Genetic Testing
Helm B, Helvaty L, Conboy E, Geddes G, Graham B, Lah M, Wetherill L, Landis B, Ware S. Performance of Dysmorphology‐Based Screening for Genetic Disorders in Pediatric Congenital Heart Disease Supports Wider Genetic Testing. Molecular Genetics & Genomic Medicine 2024, 12: e70040. PMID: 39587733, PMCID: PMC11588853, DOI: 10.1002/mgg3.70040.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseGenetic diagnosisGenetic testingChromosomal microarrayNegative predictive valuePositive predictive valueExtracardiac anomaliesGenetic disordersDysmorphic statusGenetic test resultsDysmorphology evaluationPhenotype-based screeningTest-negative case-control designCongenital heart disease patientsPediatric congenital heart diseaseCase-control designCHD cohortDysmorphic patientsPediatric patientsDysmorphology assessmentGenetic evaluationPatientsHeart diseaseScreening performanceDiagnosisA Novel Echocardiography Feature-Tracking Algorithm for Stabilized Frame-to-Frame Extraction of Aortic Root Diameters in the Parasternal Long Axis
Damen F, Ghajar-Rahimi E, Lai D, Goergen C, Landis B. A Novel Echocardiography Feature-Tracking Algorithm for Stabilized Frame-to-Frame Extraction of Aortic Root Diameters in the Parasternal Long Axis. Journal Of The American Society Of Echocardiography 2024, 38: 44-47. PMID: 39299353, PMCID: PMC11700755, DOI: 10.1016/j.echo.2024.09.005.Peer-Reviewed Original ResearchEarly ascertainment of genetic diagnoses clarifies impact on medium-term survival following neonatal congenital heart surgery
Landis B, Helm B, Durbin M, Helvaty L, Herrmann J, Johansen M, Geddes G, Ware S. Early ascertainment of genetic diagnoses clarifies impact on medium-term survival following neonatal congenital heart surgery. Journal Of Clinical Investigation 2024, 134: e180098. PMID: 39078715, PMCID: PMC11405028, DOI: 10.1172/jci180098.Peer-Reviewed Original Research
2023
A Multicenter Analysis of Abnormal Chromosomal Microarray Findings in Congenital Heart Disease
Landis B, Helvaty L, Geddes G, Lin J, Yatsenko S, Lo C, Border W, Wechsler S, Murali C, Azamian M, Lalani S, Hinton R, Garg V, McBride K, Hodge J, Ware S. A Multicenter Analysis of Abnormal Chromosomal Microarray Findings in Congenital Heart Disease. Journal Of The American Heart Association 2023, 12: e029340. PMID: 37681527, PMCID: PMC10547279, DOI: 10.1161/jaha.123.029340.Peer-Reviewed Original ResearchConceptsCopy number variantsChromosomal microarray analysisCause of congenital heart diseaseSubmicroscopic copy number variantsCongenital heart diseaseGenomic disordersCardiac phenotypeSingle-gene CNVsClinical chromosomal microarray analysisGenetic causeMulticenter analysisRegions of homozygosityCHD typesAbnormal chromosomal microarray analysisGenotype-phenotype relationshipsGenotype-phenotype associationsHeart diseaseChromosomal microarray findingsLeft ventricular obstructionPediatric cardiac centerAbnormal test resultsConotruncal defectsSeptal defectMicroarray analysisVentricular obstructionGenetic Testing Guidelines Impact Care in Newborns with Congenital Heart Defects
Durbin M, Fairman K, Helvaty L, Huang M, Li M, Abreu D, Geddes G, Helm B, Landis B, McEntire A, Mitchell D, Ware S. Genetic Testing Guidelines Impact Care in Newborns with Congenital Heart Defects. The Journal Of Pediatrics 2023, 260: 113495. PMID: 37211210, PMCID: PMC10660555, DOI: 10.1016/j.jpeds.2023.113495.Peer-Reviewed Original ResearchConceptsCongenital heart defectsGenetic testing guidelinesGenetic testingHeart defectsHospitalized newbornsPatient subtypesYield of genetic testingMultivariate analysisCross-sectional studyClinically important resultsSequence-based methodsImpact carePatient careTesting guidelinesTesting prevalenceChromosomal microarrayGene panelExome sequencingTest yieldsBirth defectsGenetic diagnosisNewbornsEvaluation practicesPatientsCareDisruption of FBN1 by an Alu element insertion: A novel genetic cause of Marfan syndrome
Helm B, Smith A, Schmit K, Landis B, Vatta M, Ware S. Disruption of FBN1 by an Alu element insertion: A novel genetic cause of Marfan syndrome. European Journal Of Medical Genetics 2023, 66: 104775. PMID: 37264881, PMCID: PMC11670311, DOI: 10.1016/j.ejmg.2023.104775.Peer-Reviewed Original ResearchConceptsAlu element insertionAlu elementsElement insertionsNon-coding regulatory regionsMolecular basisGenetic causeCopy-number variantsHuman genomic diversityMolecular basis of diseaseNext-generation sequencingGenetic testing technologiesGenomic diversityAlu insertionsMendelian diseasesHuman genomeRegulatory regionsCoding regionGene disruptionGenomic technologiesMarfan syndromeMutational eventsInsertional mutagenesisEpigenetic regulationSanger sequencingAlu retrotransposition