Benjamin Keepers, MD, PhD
Hospital ResidentAbout
Research
Publications
2024
Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression
Huang P, Xu J, Keepers B, Xie Y, Near D, Xu Y, Hua J, Spurlock B, Ricketts S, Liu J, Wang L, Qian L. Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression. Molecular Therapy - Nucleic Acids 2024, 35: 102390. PMID: 39720701, PMCID: PMC11666955, DOI: 10.1016/j.omtn.2024.102390.Peer-Reviewed Original ResearchDirect conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg
Farber G, Dong Y, Wang Q, Rathod M, Wang H, Dixit M, Keepers B, Xie Y, Butz K, Polacheck W, Liu J, Qian L. Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg. Nature Communications 2024, 15: 4170. PMID: 38755186, PMCID: PMC11098819, DOI: 10.1038/s41467-024-48354-6.Peer-Reviewed Original Research
2023
On Your MARCKS…Get Set…Go The Race to Explore Myristoylation in HF Is Underway ∗
Keepers B, Jensen B. On Your MARCKS…Get Set…Go The Race to Explore Myristoylation in HF Is Underway ∗. JACC Basic To Translational Science 2023, 8: 1283-1284. PMID: 38094683, PMCID: PMC10714165, DOI: 10.1016/j.jacbts.2023.08.007.Commentaries, Editorials and LettersTranslational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition
Xie Y, Wang Q, Yang Y, Near D, Wang H, Colon M, Nguyen C, Slattery C, Keepers B, Farber G, Wang T, Lee S, Ian Shih Y, Liu J, Qian L. Translational landscape of direct cardiac reprogramming reveals a role of Ybx1 in repressing cardiac fate acquisition. Nature Cardiovascular Research 2023, 2: 1060-1077. PMID: 38524149, PMCID: PMC10959502, DOI: 10.1038/s44161-023-00344-5.Peer-Reviewed Original ResearchOptimized protocol for direct cardiac reprogramming in mice using Ascl1 and Mef2c
Wang H, Keepers B, Liu J, Qian L. Optimized protocol for direct cardiac reprogramming in mice using Ascl1 and Mef2c. STAR Protocols 2023, 4: 102204. PMID: 36989109, PMCID: PMC10074248, DOI: 10.1016/j.xpro.2023.102204.Peer-Reviewed Original Research
2022
Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes
Wang H, Keepers B, Qian Y, Xie Y, Colon M, Liu J, Qian L. Cross-lineage potential of Ascl1 uncovered by comparing diverse reprogramming regulatomes. Cell Stem Cell 2022, 29: 1491-1504.e9. PMID: 36206732, PMCID: PMC9557912, DOI: 10.1016/j.stem.2022.09.006.Peer-Reviewed Original Research
2020
An Optimized Protocol for Human Direct Cardiac Reprogramming
Garbutt T, Zhou Y, Keepers B, Liu J, Qian L. An Optimized Protocol for Human Direct Cardiac Reprogramming. STAR Protocols 2020, 1: 100010. PMID: 32728671, PMCID: PMC7390466, DOI: 10.1016/j.xpro.2019.100010.Peer-Reviewed Original Research
2019
Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming
Zhou Y, Liu Z, Welch J, Gao X, Wang L, Garbutt T, Keepers B, Ma H, Prins J, Shen W, Liu J, Qian L. Single-Cell Transcriptomic Analyses of Cell Fate Transitions during Human Cardiac Reprogramming. Cell Stem Cell 2019, 25: 149-164.e9. PMID: 31230860, PMCID: PMC6684137, DOI: 10.1016/j.stem.2019.05.020.Peer-Reviewed Original ResearchWhat's in a cardiomyocyte – And how do we make one through reprogramming?
Keepers B, Liu J, Qian L. What's in a cardiomyocyte – And how do we make one through reprogramming? Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research 2019, 1867: 118464. PMID: 30922868, PMCID: PMC6911029, DOI: 10.1016/j.bbamcr.2019.03.011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2018
Tension-dependent regulation of mammalian Hippo signaling through LIMD1
Ibar C, Kirichenko E, Keepers B, Enners E, Fleisch K, Irvine K. Tension-dependent regulation of mammalian Hippo signaling through LIMD1. Journal Of Cell Science 2018, 131: jcs214700. PMID: 29440237, PMCID: PMC5897721, DOI: 10.1242/jcs.214700.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAdherens JunctionsAnimalsCarrier ProteinsCell CountCell ProliferationCo-Repressor ProteinsCytoskeletal ProteinsCytoskeletonDogsHEK293 CellsHippo Signaling PathwayHumansIntracellular Signaling Peptides and ProteinsLIM Domain ProteinsMechanotransduction, CellularPhosphoproteinsProtein Serine-Threonine Kinasesrho-Associated KinasesSignal TransductionTranscription FactorsTumor Suppressor ProteinsYAP-Signaling Proteins
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