Atagun Isiktas
Postgraduate Associate in NeuroscienceAbout
Research
Publications
2024
D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
Zachry JE, Kutlu MG, Yoon HJ, Leonard MZ, Chevée M, Patel DD, Gaidici A, Kondev V, Thibeault KC, Bethi R, Tat J, Melugin PR, Isiktas AU, Joffe ME, Cai DJ, Conn PJ, Grueter BA, Calipari ES. D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning. Neuron 2024, 112 DOI: 10.1016/j.neuron.2023.11.023.Peer-Reviewed Original Research
2023
D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning
Zachry J, Kutlu M, Yoon H, Leonard M, Chevée M, Patel D, Gaidici A, Kondev V, Thibeault K, Bethi R, Tat J, Melugin P, Isiktas A, Joffe M, Cai D, Conn P, Grueter B, Calipari E. D1 and D2 medium spiny neurons in the nucleus accumbens core have distinct and valence-independent roles in learning. Neuron 2023, 112: 835-849.e7. PMID: 38134921, PMCID: PMC10939818, DOI: 10.1016/j.neuron.2023.11.023.Peer-Reviewed Original ResearchConceptsD2 medium spiny neuronsMedium spiny neuronsNucleus accumbens coreNucleus accumbensSpiny neuronsValue-based learningResponse to cuesAccumbens coreAssociative learningNeuronal levelControl learningIndividual neuron levelD1CuesAccumbensLearningNeuronsPrediction errorValenceStimuliNucleusContingency
2022
Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation
Isiktas A, Eshov A, Yang S, Guo J. Systematic generation and imaging of tandem repeats reveal base-pairing properties that promote RNA aggregation. Cell Reports Methods 2022, 2: 100334. PMID: 36452875, PMCID: PMC9701603, DOI: 10.1016/j.crmeth.2022.100334.Peer-Reviewed Original ResearchConceptsBase pairsRNA aggregationRNA-RNA interactionsLive-cell imagingConsecutive base pairsNoncanonical base pairsRNA aggregatesRepeat RNARepeat DNAMolecular basisRepeat sequencesMolecular mechanismsTandem repeatsRNAHexanucleotide repeatsStructural determinantsGGGGCC hexanucleotide repeatBase-pairing propertiesCommon pathological featureRepeatsSequenceUnifying modelGeneralizable approachDistinct propertiesEnhanced aggregationCellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organsDopamine signaling in the nucleus accumbens core mediates latent inhibition
Kutlu MG, Zachry JE, Melugin PR, Tat J, Cajigas S, Isiktas AU, Patel DD, Siciliano CA, Schoenbaum G, Sharpe MJ, Calipari ES. Dopamine signaling in the nucleus accumbens core mediates latent inhibition. Nature Neuroscience 2022, 25 DOI: 10.1038/s41593-022-01126-1.Peer-Reviewed Original ResearchDopamine signaling in the nucleus accumbens core mediates latent inhibition
Kutlu M, Zachry J, Melugin P, Tat J, Cajigas S, Isiktas A, Patel D, Siciliano C, Schoenbaum G, Sharpe M, Calipari E. Dopamine signaling in the nucleus accumbens core mediates latent inhibition. Nature Neuroscience 2022, 25: 1071-1081. PMID: 35902648, PMCID: PMC9768922, DOI: 10.1038/s41593-022-01126-1.Peer-Reviewed Original ResearchConceptsNucleus accumbens coreAccumbens coreAssociative learningLatent inhibitionDopamine signalingOptogenetic manipulationNeutral stimuliDopamine responseNeural mechanismsDopamineHabituation periodHabituationResponse patternsCuesStimuliLearningNucleusAssociationBehaviorAssociated FactorsNeural controlResponsePublisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
Sun Y, Eshov A, Zhou J, Isiktas AU, Guo JU. Publisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. Nature Communications 2022, 13: 279. PMID: 34992216, PMCID: PMC8738755, DOI: 10.1038/s41467-021-27859-4.Peer-Reviewed Original Research
2021
Accumbal D1 and D2 medium spiny neurons control distinct learning parameters in complex behavior
Zachry J, Kutlu M, Melugin P, Isiktas A, Calipari E. Accumbal D1 and D2 medium spiny neurons control distinct learning parameters in complex behavior. The FASEB Journal 2021, 35 DOI: 10.1096/fasebj.2021.35.s1.03928.Peer-Reviewed Original ResearchValue-based decision-makingD2-MSN activityD2-MSNNucleus accumbensD1-MSNConditioning taskIn vivo fiber photometryD2 medium spiny neuronsD1-MSN activityNucleus accumbens coreFear conditioning taskOperant conditioning taskMedium spiny neuronsNeural activity patternsGoal-oriented behaviorBehaving animalsD2-MSNsCue learningReinforcement schedulePredictive cuesUnconditioned stimulusMotivated behaviorSelf-StimulationDisrupt learningBehavioral actions
2020
C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
Sun Y, Eshov A, Zhou J, Isiktas AU, Guo JU. C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression. Nature Communications 2020, 11: 3354. PMID: 32620797, PMCID: PMC7335171, DOI: 10.1038/s41467-020-17129-0.Peer-Reviewed Original ResearchMeSH KeywordsAmyotrophic Lateral SclerosisAnimalsC9orf72 ProteinCell Line, TumorCell SurvivalDatasets as TopicDNA Repeat ExpansionEmbryo, MammalianFemaleFrontal LobeFrontotemporal DementiaHumansIntronsMiceNeuronsNonsense Mediated mRNA DecayPrimary Cell CultureProtein BiosynthesisRNA HelicasesRNA-SeqRNA, MessengerTrans-ActivatorsConceptsArginine-rich dipeptide repeatsNonsense-mediated decayRNA surveillanceTranslational repressionNMD inhibitionDipeptide repeatsRNA Decay mechanismsGlobal translational repressionStress granule formationC9ALS/FTDRNA decayFrameshift 1Repeat regionFamilial amyotrophic lateral sclerosisGranule formationCultured cellsFTD brainC9orf72 geneRepressionSurvival of neuronsRepeatsAmyotrophic lateral sclerosisMutantsGenesLateral sclerosis