About
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Postdoctoral Fellow
Biography
Arthur Stem received his Ph.D. in Toxicology from the University of Colorado Anschutz Medical Campus. His dissertation centered on contributions of environmental toxicants to the pathogenesis of chronic kidney disease of unknown etiology. He joined the Vasilis lab in 2024 and is using his background in environmental and mechanistic toxicology to elucidate how environmental exposures influence the development of liver disease.
Last Updated on February 07, 2025.
Education & Training
- PhD
- University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Toxicology (2024)
- BS
- University of Arkansas at Little Rock, Biology (2014)
- AS
- National Park Community College, Science (2011)
Research
Publications
2026
Quantitative Spatial Analysis of PFAS in Nine Biological Tissues from Mouse via MALDI-TIMS-MSI
Nikolopoulou V, Stem A, Alayyoub M, Vasiliou V, Aalizadeh R. Quantitative Spatial Analysis of PFAS in Nine Biological Tissues from Mouse via MALDI-TIMS-MSI. Environmental Science And Technology 2026, 60: 16419-16434. PMID: 42219700, DOI: 10.1021/acs.est.5c14803.Peer-Reviewed Original ResearchIntegrated Multi-Omics Reveals Synergistic Hepatotoxicity of Ethanol and PFOS Co-Exposure
Stem A, Alayyoub M, Aalizadeh R, Nikolopoulou V, Lisgara A, Shvartsman A, Anitha M, Patterson A, Coble R, Rushing B, Sumner S, Vasiliou V. Integrated Multi-Omics Reveals Synergistic Hepatotoxicity of Ethanol and PFOS Co-Exposure. Chemico-Biological Interactions 2026, 434: 112101. PMID: 42036057, DOI: 10.1016/j.cbi.2026.112101.Peer-Reviewed Original ResearchExposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies
Tanghal R, Beglarian E, Stem A, Aung M, Alderete T, Ducatman A, Vasiliou V, McConnell R, Conti D, Chatzi L. Exposure to Per- and Polyfluoroalkyl Substances and Liver Cancer: A Systematic Review of Animal and Epidemiological Studies. Environmental Science And Technology 2026, 60: 2816-2831. PMID: 41543329, PMCID: PMC12875370, DOI: 10.1021/acs.est.5c05535.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging
Nikolopoulou V, Stem A, Vasiliou V, Aalizadeh R. Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging. Journal Of The American Society For Mass Spectrometry 2025, 36: 2460-2469. PMID: 41147643, DOI: 10.1021/jasms.5c00211.Peer-Reviewed Original ResearchSynergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, 208: 9-31. PMID: 40737496, PMCID: PMC12599875, DOI: 10.1093/toxsci/kfaf110.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsIntegrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy
Koutromanos I, Legaki E, Dovrolis N, Vassilopoulos E, Stem A, Vasiliou V, Tzavellas E, Gazouli M. Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy. Human Genomics 2025, 19: 78. PMID: 40646629, PMCID: PMC12255058, DOI: 10.1186/s40246-025-00793-y.Peer-Reviewed Original ResearchAdvancing translational exposomics: bridging genome, exposome and personalized medicine
Sarigiannis D, Karakitsios S, Anesti O, Stem A, Valvi D, Sumner S, Chatzi L, Snyder M, Thompson D, Vasiliou V. Advancing translational exposomics: bridging genome, exposome and personalized medicine. Human Genomics 2025, 19: 48. PMID: 40307849, PMCID: PMC12044731, DOI: 10.1186/s40246-025-00761-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology. Particle And Fibre Toxicology 2025, 22: 3. PMID: 39910563, PMCID: PMC11800628, DOI: 10.1186/s12989-025-00619-8.Peer-Reviewed Original ResearchBasic Helix-Loop-Helix Transcription FactorsCell LineChronic Kidney Diseases of Uncertain EtiologyHumansKidney Tubules, ProximalNanoparticlesOccupational ExposureOxidation-ReductionOxidative StressProteomeProteomicsReactive Oxygen SpeciesReceptors, Aryl HydrocarbonRenal Insufficiency, ChronicSaccharumSilicon DioxideSulfhydryl Compounds
2024
Response to Avoid Preclinical Errors When Using Urine Biomarkers of Exposure
Stem A, Brindley S, Rogers K, Salih A, Roncal-Jimenez C, Johnson R, Newman L, Butler-Dawson J, Krisher L, Brown J. Response to Avoid Preclinical Errors When Using Urine Biomarkers of Exposure. Kidney International Reports 2024, 10: 281-283. PMID: 39810784, PMCID: PMC11725806, DOI: 10.1016/j.ekir.2024.11.003.Commentaries, Editorials and LettersHealth burden of sugarcane burning on agricultural workers and nearby communities
Stem A, Gibb M, Roncal-Jimenez C, Johnson R, Brown J. Health burden of sugarcane burning on agricultural workers and nearby communities. Inhalation Toxicology 2024, 36: 327-342. PMID: 38349733, PMCID: PMC11260540, DOI: 10.1080/08958378.2024.2316875.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
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