Anahi Odell
Associate Research ScientistCards
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Research
Publications
2025
488 EGFR-STAT1 Pathway Drives Fibrosis Initiation in Fibroinflammatory Skin Diseases
Odell A, Newton N, Eisenstein A, Micevic G, Flavell R, Odell I. 488 EGFR-STAT1 Pathway Drives Fibrosis Initiation in Fibroinflammatory Skin Diseases. Journal Of Investigative Dermatology 2025, 145: s352. DOI: 10.1016/j.jid.2025.10.500.Peer-Reviewed Original ResearchEGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases
Odell A, Newton N, Eisenstein A, Micevic G, Flavell R, Odell I. EGFR-STAT1 pathway drives fibrosis initiation in fibroinflammatory skin diseases. Nature Communications 2025, 16: 8969. PMID: 41068129, PMCID: PMC12511620, DOI: 10.1038/s41467-025-64648-9.Peer-Reviewed Original ResearchConceptsInflammatory skin diseaseSkin diseasesChronic inflammatory skin diseaseKeratinocyte-derived signalsSkin fibrosis developmentActivation of STAT1Chronic skin inflammationExpression of fibrotic genesGene expression profilesScRNA-seqFibrotic skin diseasesSkin fibrosisSkin inflammationSTAT1 activationEGFR ligandsFibrotic genesHealthy controlsFibrosis developmentExpression profilesSTAT1 inhibitionSTAT1FibrosisActivated keratinocytesHigher expressionFibrosis initiationSclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody
Newton N, Agrawal K, Odell A, Tracy T, Hackett C, Eldrup A, Whitfield M, Martyanov V, Girardi M, Sefik E, Flavell R, Odell I. Sclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody. Blood 2025, 146: 3201-3212. PMID: 40961242, PMCID: PMC12643462, DOI: 10.1182/blood.2025029836.Peer-Reviewed Original ResearchScleroderma/systemic sclerosisTherapeutic antibodiesChronic graft-versus-host diseaseSclerotic skinGraft-versus-host diseasePatients' qualityFibrotic diseasesLungs of patientsEndogenous TLR4 ligandsPatients' quality of lifeKnock-In MiceFibrotic skin diseasesAntifibrotic mechanismsSingle-cell transcriptome profilingSkin fibrosisLocalized sclerodermaNeutralizing antibodiesEGFR ligandsEREG expressionTLR4 ligandTIMP1 expressionTLR4 signalingPatient mortalityPatientsType I collagen1013 Sclerotic graft-vs-host disease shares dysregulated gene expression with scleroderma that can be targeted with epiregulin inhibition
Odell I, Newton N, Odell A, Girardi M, Flavell R. 1013 Sclerotic graft-vs-host disease shares dysregulated gene expression with scleroderma that can be targeted with epiregulin inhibition. Journal Of Investigative Dermatology 2025, 145: s175. DOI: 10.1016/j.jid.2025.06.1030.Peer-Reviewed Original Research0958 Nuclear epidermal growth factor receptor modulates skin laxity and fibrosis
Odell A, Newton N, Flavell R, Odell I. 0958 Nuclear epidermal growth factor receptor modulates skin laxity and fibrosis. Journal Of Investigative Dermatology 2025, 145: s166. DOI: 10.1016/j.jid.2025.06.974.Peer-Reviewed Original Research1006 Reduction of type I interferon biomarkers by cGAS inhibition in scleroderma and GvHD skin
Newton N, Odell A, Odell I. 1006 Reduction of type I interferon biomarkers by cGAS inhibition in scleroderma and GvHD skin. Journal Of Investigative Dermatology 2025, 145: s174. DOI: 10.1016/j.jid.2025.06.1023.Peer-Reviewed Original Research
2024
029 Investigation of cGAS-STING signaling in scleroderma and GvHD Skin
Newton N, Odell A, Odell I. 029 Investigation of cGAS-STING signaling in scleroderma and GvHD Skin. Journal Of Investigative Dermatology 2024, 144: s5. DOI: 10.1016/j.jid.2024.06.045.Peer-Reviewed Original Research
2023
IL-6 trans-signaling in a humanized mouse model of scleroderma
Odell I, Agrawal K, Sefik E, Odell A, Caves E, Kirkiles-Smith N, Horsley V, Hinchcliff M, Pober J, Kluger Y, Flavell R. IL-6 trans-signaling in a humanized mouse model of scleroderma. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2306965120. PMID: 37669366, PMCID: PMC10500188, DOI: 10.1073/pnas.2306965120.Peer-Reviewed Original ResearchConceptsBone marrow-derived immune cellsIL-6Human hematopoietic stem cellsImmune cellsT cellsScleroderma skinSoluble IL-6 receptorCD8 T cellsHumanized mouse modelPathogenesis of sclerodermaMesenchymal cellsFibroblast-derived IL-6IL-6 receptorIL-6 signalingT cell activationHuman IL-6Human T cellsExpression of collagenFibrosis improvementPansclerotic morpheaHuman endothelial cellsHumanized miceReduced markersSkin graftsHuman CD4
2015
Yeast Three-Hybrid Screen Identifies TgBRADIN/GRA24 as a Negative Regulator of Toxoplasma gondii Bradyzoite Differentiation
Odell A, Tran F, Foderaro J, Poupart S, Pathak R, Westwood N, Ward G. Yeast Three-Hybrid Screen Identifies TgBRADIN/GRA24 as a Negative Regulator of Toxoplasma gondii Bradyzoite Differentiation. PLOS ONE 2015, 10: e0120331. PMID: 25789621, PMCID: PMC4366382, DOI: 10.1371/journal.pone.0120331.Peer-Reviewed Original ResearchConceptsYeast three-hybrid analysisThree-hybrid analysisProtozoan parasite Toxoplasma gondiiLatent bradyzoite stageParasite Toxoplasma gondiiParasite lytic cycleParasite cGMP-dependent protein kinaseBradyzoite stageT. gondiiBradyzoite differentiationToxoplasma gondiiParasite life cycleDifferentiation-enhancing effectParasitesPathogenic microorganismsParasite differentiationSmall molecule mechanism of actionNegative regulatorKnockout parasitesParasite proteinsInhibitor of differentiationYeastHuman pathogensLife cycleLytic cycle
2013
A Modular Approach to Triazole-Containing Chemical Inducers of Dimerisation for Yeast Three-Hybrid Screening
Tran F, Odell A, Ward G, Westwood N. A Modular Approach to Triazole-Containing Chemical Inducers of Dimerisation for Yeast Three-Hybrid Screening. Molecules 2013, 18: 11639-11657. PMID: 24064457, PMCID: PMC4031444, DOI: 10.3390/molecules180911639.Peer-Reviewed Original ResearchConceptsSmall molecule-protein interactionsMolecule-protein interactionsSynthetic strategyCompound 2Target identification strategiesDimerisationSynthesisTarget identification methodsYeast three-hybridYeast three-hybrid screenProtein binding partnersSynthetic componentsThree-hybrid screenModular natureThree-hybridY3HModular approachBinding partners
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