Alexander Joseph Rossi, MD
Assistant Professor of Surgery ( Colon & Rectal)Cards
About
Research
Publications
2025
Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth.
Sinha S, Panda A, Xavier das Neves R, Nwosu Z, Xu K, van Beek E, Desai P, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi A, Ayabe R, Wach M, McDonald J, Ruff S, Verbus E, Saif A, Eade A, Larrain C, Friedman L, Gupta S, Ranjan A, Teke M, Khan T, Pu T, Sarvestani A, Ryan C, Lambdin J, Luberice K, Gregory S, Lux S, Hong H, Luna A, Alexander I, Akmal S, Rehman S, Rainey A, Prickett T, Koparde V, Sevilla S, Kuhn S, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam M, Wu X, Jenkins L, Blakely A, Davis J, Trinchieri G, Singh P, Yang J, Pasca di Magliano M, Lyssiotis C, Yaffe M, Shevach E, Hernandez J. Expression of IMPACT Curtails Metabolic Plasticity and Augments NK Cell Killing to Abrogate Metastatic Growth. Cancer Discovery 2025, of1-of30. PMID: 41025961, DOI: 10.1158/2159-8290.cd-24-1055.Peer-Reviewed Original ResearchEndogenous competitive inhibitorTumor immunogenicityIntegrated stress responseImmune checkpoint blockadeExpression of MHC-I moleculesNK cell killingCell-mediated destructionAggressive epithelial tumorMetastatic tumor cellsMHC-I moleculesCheckpoint blockadeHepatic metastasesNK ligandsEpithelial tumorsNK cellsMetabolic plasticityMetastatic growthTumor cellsAmino acid transportDistant organsCell killingMetabolic controlTumorPancreatic cellsAcid transportExpression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth.
Sinha S, Panda A, Xavier das Neves R, Nwosu Z, Xu K, van Beek E, Desai P, Sindiri S, Chempati S, Remmert K, Gasmi B, Bojmar L, Zambirinis C, Rossi A, Ayabe R, Wach M, McDonald J, Ruff S, Verbus E, Saif A, Eade A, Larrain C, Friedman L, Gupta S, Ranjan A, Teke M, Khan T, Pu T, Sarvestani A, Ryan C, Lambdin J, Luberice K, Gregory S, Lux S, Hong H, Luna A, Alexander I, Akmal S, Rehman S, Rainey A, Prickett T, Koparde V, Sevilla S, Kuhn S, Chan K, Sun Z, Bubunenko N, Li E, Hannah C, Gaga G, Andresson T, Cam M, Wu X, Jenkins L, Blakely A, Davis J, Trinchieri G, Singh P, Yang J, Pasca di Magliano M, Lyssiotis C, Yaffe M, Shevach E, Hernandez J. Expression of IMPACT curtails metabolic plasticity and augments NK cell killing to abrogate metastatic growth. Cancer Discovery 2025, of1-of30. PMID: 40736016, DOI: 10.1158/2159-8290.cd-24-1055.Peer-Reviewed Original ResearchImmune checkpoint blockadeEndogenous competitive inhibitorNatural killerExpression of MHC-I moleculesNK cell killingAggressive epithelial tumorMHC-I moleculesCheckpoint blockadeTumor immunogenicityHepatic metastasesNK cellsEpithelial tumorsMetastatic growthAmino acid transportCell killingMetabolic controlPancreatic cellsAcid transportTumorMouse liverMetabolic plasticityCDNA screeningCellsExpressionMetastasis
2022
A Phase III, Multicenter, Randomized Controlled Trial Investigating 1-cm Versus 2-cm Surgical Excision Margins for Stage II Primary Cutaneous Melanoma (MelMarT-II)
Rossi A, Verbus E, Faries M, Moncrieff M, Henderson M, Hernandez J, Lowe M. A Phase III, Multicenter, Randomized Controlled Trial Investigating 1-cm Versus 2-cm Surgical Excision Margins for Stage II Primary Cutaneous Melanoma (MelMarT-II). Annals Of Surgical Oncology 2022, 29: 4050-4051. PMID: 35451728, DOI: 10.1245/s10434-022-11766-z.Peer-Reviewed Original ResearchPatient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis
Khan T, Verbus E, Rossi A, Hernandez J, Davis J, Coakley B, Blakely A. Patient demographics, clinicopathologic features, and outcomes in wild-type gastrointestinal stromal tumor: a national cohort analysis. Scientific Reports 2022, 12: 5774. PMID: 35388076, PMCID: PMC8987058, DOI: 10.1038/s41598-022-09745-1.Peer-Reviewed Original ResearchConceptsWild-type gastrointestinal stromal tumoursGastrointestinal stromal tumorsNational Cancer DatabaseOverall survivalClinicopathological featuresStromal tumorsPrimary siteRetrospective evaluation of patientsRetrospective evaluationNational cohort analysisMedian diagnosis agePrincipal treatment modalityKaplan-Meier analysisWild-type KITLimited treatment optionsEvaluation of patientsCox proportional hazards modelsProportional hazards modelRare tumorSurgical resectionSystemic therapyCancer DatabaseIntestinal primaryMitotic countPatient demographicsPembrolizumab Compared with Standard-of-Care Observation in Treating Patients with Completely Resected Stage I–III Merkel Cell Cancer (STAMP)
Teke M, Rossi A, Hernandez J, Gastman B. Pembrolizumab Compared with Standard-of-Care Observation in Treating Patients with Completely Resected Stage I–III Merkel Cell Cancer (STAMP). Annals Of Surgical Oncology 2022, 29: 3379-3380. PMID: 35258767, DOI: 10.1245/s10434-022-11498-0.Peer-Reviewed Original ResearchEfficacy of Neoadjuvant Intratumoral Darleukin/Fibromun (L19IL2 + L19TNF) in Patients with Clinical Stage IIIB/C Melanoma (Neo-DREAM)
Saif A, Rossi A, Sarnaik A, Hernandez J, Zager J. Efficacy of Neoadjuvant Intratumoral Darleukin/Fibromun (L19IL2 + L19TNF) in Patients with Clinical Stage IIIB/C Melanoma (Neo-DREAM). Annals Of Surgical Oncology 2022, 29: 3377-3378. PMID: 35229218, DOI: 10.1245/s10434-022-11447-x.Peer-Reviewed Original ResearchAssociation Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk
Gamble L, Rossi A, Fasaye G, Kesserwan C, Hernandez J, Blakely A, Davis J. Association Between Hereditary Lobular Breast Cancer Due to CDH1 Variants and Gastric Cancer Risk. JAMA Surgery 2022, 157: 18-22. PMID: 34643667, PMCID: PMC8515254, DOI: 10.1001/jamasurg.2021.5118.Peer-Reviewed Original ResearchConceptsHereditary lobular breast cancerHereditary diffuse gastric cancerFamily history of gastric cancerHistory of gastric cancerGastric cancer riskP/LP variantsProspective cohort studyCancer riskCDH1 variantsFamily historyFamily history of breast cancerFamily history of cancerHistory of breast cancerFamily history of breastBreast cancerHereditary cancer riskSignet ring cell carcinomaHistory of breastHistory of cancerFamily medical historyDiffuse gastric cancerGastric cancerProspective cohort study of patientsCohort study of patientsQuaternary medical center
2021
Preoperative Use of a Radiation Boost to Enhance Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer
Verbus E, Rossi A, Clark A, Taunk N, Nayak A, Hernandez J, Tchou J. Preoperative Use of a Radiation Boost to Enhance Effectiveness of Immune Checkpoint Blockade Therapy in Operable Breast Cancer. Annals Of Surgical Oncology 2021, 29: 1530-1532. PMID: 34783947, DOI: 10.1245/s10434-021-10987-y.Peer-Reviewed Original ResearchIs Axillary Radiation not Inferior to Axillary Dissection for Sentinel Lymph Node-Positive Breast Cancer After Neoadjuvant Chemotherapy?
Khan TM, Rossi AJ, Suman V, Haffty B, Hernandez JM, Boughey JC. Is Axillary Radiation not Inferior to Axillary Dissection for Sentinel Lymph Node-Positive Breast Cancer After Neoadjuvant Chemotherapy? Annals Of Surgical Oncology 2021, 29: 1526-1527. PMID: 34671883, DOI: 10.1245/s10434-021-10830-4.Peer-Reviewed Original ResearchSurgical Excision Versus Neoadjuvant Radiotherapy Followed by Delayed Surgical Excision of Ductal Carcinoma In Situ (NORDIS)
Rossi A, Verbus E, Horst K, De Martini W, Allison K, Hernandez J, Wapnir I. Surgical Excision Versus Neoadjuvant Radiotherapy Followed by Delayed Surgical Excision of Ductal Carcinoma In Situ (NORDIS). Annals Of Surgical Oncology 2021, 29: 1528-1529. PMID: 34471985, DOI: 10.1245/s10434-021-10552-7.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
Clinical Care
Overview
Clinical Specialties
Colorectal Surgery; Gastrointestinal Surgery
Board Certifications
Surgery General
- Certification Organization
- AB of Surgery
- Original Certification Date
- 2024
Get In Touch
Contacts
Appointment Number
Mailing Address
Colorectal Surgery
Section of Gastrointestinal Surgery, Yale University School of Medicine P.O. Box 208062
New Haven, Connecticut 06511
United States
Administrative Support
Locations
Colorectal Surgery
Academic Office
350 George Street, Fl 3rd, Ste B393
New Haven, CT 06511