Aaron S. Eisman, MD, PhD

Aaron S. Eisman is an M.D. / Ph.D. in Biomedical Informatics and Computational Biology. He earned his Sc.B. in Applied Mathematics at Brown University. Subsequently, he spent two years as a clinical research coordinator for the Cardiopulmonary Exercise Laboratory at Massachusetts General Hospital under the direction of Dr. Gregory Lewis. As a member of that research team, Dr. Eisman worked on a project demonstrating that increased pulmonary capillary wedge pressure relative to cardiac output during exercise predicts exercise capacity and heart failure outcomes. These findings have informed the definitions of heart failure with preserved ejection fraction (2021) and pulmonary hypertension (2022) in the European Society of Cardiology / European Respiratory Society guidelines.

Dr. Eisman returned to Brown University for his M.D. and Ph.D. training under the direction of Drs. Neil Sarkar and Elizabeth Chen. For his Ph.D. thesis, he presented a translational bioinformatics framework that bridged 1) health informatics, where aggregate electronic health records provide a clinical rendering of atherosclerotic cardiovascular disease and primary prevention practices, 2) bioinformatics by leveraging multi-omics data to elucidate the biological basis of serum cardio-metabolic protein-to-metabolite interactions, and 3) a translational mechanism whereby the knowledge produced from one end of the translational bioinformatics spectrum becomes the data for investigation in the other.

Dr. Eisman completed his internship and residency training in internal medicine at Yale-New Haven Hospital. He is now a Cardiovascular Medicine Clinical Fellow at Yale-New Haven Hospital as part of the Physician-Scientist Training Pathway in Cardiovascular Medicine.