Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsRichard Silverman, MD
Assistant Clinical ProfessorAbout
Research
Publications
2026
Dynamic tail amine interactions drive isoform selectivity for potent human neuronal nitric oxide synthase inhibitors
Awasthi A, Kang K, Silverman R. Dynamic tail amine interactions drive isoform selectivity for potent human neuronal nitric oxide synthase inhibitors. Medicinal Chemistry Research 2026, 35: 757-764. PMID: 42078120, PMCID: PMC13128701, DOI: 10.1007/s00044-026-03552-3.Peer-Reviewed Original ResearchInactivation of ornithine aminotransferase by (1R,4S)-4-Amino-3-(trifluoromethyl)cyclopent-2-ene-1-carboxylic acid via a stable quinonoid intermediate
Kang K, Vargas A, Zhu W, Sokolenko I, Liu D, Silverman R. Inactivation of ornithine aminotransferase by (1R,4S)-4-Amino-3-(trifluoromethyl)cyclopent-2-ene-1-carboxylic acid via a stable quinonoid intermediate. Medicinal Chemistry Research 2026, 35: 792-803. PMID: 42078119, PMCID: PMC13128779, DOI: 10.1007/s00044-026-03538-1.Peer-Reviewed Original ResearchTargeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator
Kang K, Vargas A, Ferreira L, Soye B, Corrigan M, Zhang C, Wang F, Duan D, Kelleher N, Hohmann A, Liu D, Silverman R. Targeting Conformational Flexibility of a Reactive Intermediate to Enhance Selectivity of a GABA Aminotransferase Inactivator. Journal Of The American Chemical Society 2026, 148: 8736-8748. PMID: 41711325, PMCID: PMC12927612, DOI: 10.1021/jacs.5c21138.Peer-Reviewed Original ResearchEnhancement of Potency and Selectivity of 2‑Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors
Ansari A, Kang K, Li H, Hardy C, Rathnayake A, Awasthi A, Poulos T, Silverman R. Enhancement of Potency and Selectivity of 2‑Aminoquinoline-Based Human Neuronal Nitric Oxide Synthase Inhibitors. Journal Of Medicinal Chemistry 2026, 69: 3779-3795. PMID: 41635994, PMCID: PMC12926790, DOI: 10.1021/acs.jmedchem.5c01679.Peer-Reviewed Original ResearchPotent, Selective, and Brain Penetrant Ether-Linked 2‑Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase with Excellent Oral Bioavailability
Ansari A, Chrzanowski R, Li H, Hardy C, Awasthi A, Poulos T, Silverman R. Potent, Selective, and Brain Penetrant Ether-Linked 2‑Aminopyridine Inhibitors of Human Neuronal Nitric Oxide Synthase with Excellent Oral Bioavailability. Journal Of Medicinal Chemistry 2026, 69: 3506-3518. PMID: 41630196, PMCID: PMC13001636, DOI: 10.1021/acs.jmedchem.5c03568.Peer-Reviewed Original ResearchNew Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma
Awasthi A, Patel A, Li H, Kang K, Hardy C, Ansari A, Nowar R, Hasan E, Yang S, Poulos T, Silverman R. New Inhibitors of Neuronal Nitric Oxide Synthase for the Treatment of Melanoma. Journal Of Medicinal Chemistry 2026, 69: 2310-2329. PMID: 41615895, PMCID: PMC12895717, DOI: 10.1021/acs.jmedchem.5c02154.Peer-Reviewed Original Research
2025
Identification of a glia‐associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU‐9
Kranz D, de Leon Velez O, Ulupinar E, Ozdinler P, Silverman R, Klein W. Identification of a glia‐associated amyloid β oligomer subtype and the rescue from reactive astrogliosis by inhibitor NU‐9. Alzheimer's & Dementia 2025, 21: e70968. PMID: 41410237, PMCID: PMC12712868, DOI: 10.1002/alz.70968.Peer-Reviewed Original ResearchModifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis
Elmansy M, Soares P, dos Remedios J, Nowar R, Fox S, Yu A, Klein W, Morimoto R, Silverman R. Modifications of NU-9, a potent protein aggregation inhibitor. Properties and activity in a cellular model of amyotrophic lateral sclerosis. Bioorganic Chemistry 2025, 167: 109190. PMID: 41223590, PMCID: PMC12648443, DOI: 10.1016/j.bioorg.2025.109190.Peer-Reviewed Original ResearchKinetically Controlled aza-Michael/Epimerization Cascade Enables a Scalable Total Synthesis of Putative (+)‑Fumigaclavine F
Dukes A, Weerawarna P, Silverman R. Kinetically Controlled aza-Michael/Epimerization Cascade Enables a Scalable Total Synthesis of Putative (+)‑Fumigaclavine F. Organic Letters 2025, 27: 10174-10179. PMID: 40864606, PMCID: PMC12459949, DOI: 10.1021/acs.orglett.5c03284.Peer-Reviewed Original ResearchTargeting Neuronal Nitric Oxide Synthase (nNOS) as a Novel Approach to Enhancing the Anti-Melanoma Activity of Immune Checkpoint Inhibitors
Patel A, Tong S, Lozada K, Awasthi A, Silverman R, Totonchy J, Yang S. Targeting Neuronal Nitric Oxide Synthase (nNOS) as a Novel Approach to Enhancing the Anti-Melanoma Activity of Immune Checkpoint Inhibitors. Pharmaceutics 2025, 17: 691. PMID: 40574005, PMCID: PMC12196278, DOI: 10.3390/pharmaceutics17060691.Peer-Reviewed Original Research