Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsJoshua Farber, DO
Clinical InstructorAbout
Research
Publications
2026
A Novel CD147-Targeting Nanobody for Immuno-PET Imaging of Liver Cancer.
Nambiar D, Esparza T, Lee W, Chung J, Olkowski C, Ghaemi B, Basuli F, Shi J, Baidoo K, Sheehan-Klenk J, Makala H, Zhang H, Farber J, Choyke P, Escorcia F, Jacobson O. A Novel CD147-Targeting Nanobody for Immuno-PET Imaging of Liver Cancer. Journal Of Nuclear Medicine 2026, jnumed.125.271565. PMID: 41956563, DOI: 10.2967/jnumed.125.271565.Peer-Reviewed Original ResearchTumor-to-background ratioTumor-to-backgroundImmuno-PET imagingOrthotopic liver tumorsHepatocellular carcinomaHuman CD147Liver tumorsPET imaging agentMethods:Liver cancerMurine HCC modelMonitoring Treatment ResponseHepatocellular carcinoma tumorsCancer-related mortalitySame-day imagingEnzyme-linked immunosorbent assayImaging agentsLocoregional therapyPET/CT imagingCancer cell linesTumor localizationTumor visualizationHCC modelLiver cancer cell linesTumor xenografts
2025
Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9.
Jacobson O, Zhang H, Olkowski C, Ghaemi B, Basuli F, Shi J, Bell M, Parween F, Ganesan S, Esparza T, Escorcia F, Choyke P, Farber J. Monitoring T-Cell Activation in the Tumor Microenvironment by PET Imaging of the Chemokine CXCL9. Journal Of Nuclear Medicine 2025, 66: 1372-1377. PMID: 40813232, PMCID: PMC12410298, DOI: 10.2967/jnumed.125.269795.Peer-Reviewed Original ResearchConceptsC-X-C motif chemokine ligand 9T cell activationT cell-engaging therapiesHumanized mouse modelT cellsTumor microenvironmentIFN-gXenograft modelGroup 1 innate lymphoid cellsEfficacy of cancer immunotherapyEngaging therapiesMethods:Biomarkers of immune activationTumor-to-background ratioResults:PET imagingResponse to immunotherapyTumor-to-backgroundImmune-mediated diseasesMonitoring of immune responsesSubcutaneous xenograft modelChemokine ligand 9Monitoring T-cell activationNoninvasive visualizationNoninvasive monitoringMigration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines
Parween F, Singh S, Kathuria N, Zhang H, Ashida S, Otaizo-Carrasquero F, Shamsaddini A, Gardina P, Ganesan S, Kabat J, Lorenzi H, Riley D, Myers T, Pittaluga S, Bielekova B, Farber J. Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines. Nature Communications 2025, 16: 1978. PMID: 40000641, PMCID: PMC11861662, DOI: 10.1038/s41467-025-57002-6.Peer-Reviewed Original ResearchConceptsEndothelial cellsTransendothelial migrationCCR2 ligandsFunction of CCR6Migration arrestChemokine receptor CCR6T cell receptor activationCerebrospinal fluid of patientsActivation-associated genesFluid of patientsActivated endothelial cellsEC surfaceTh17 signatureReceptor CCR6Th17 cellsT cellsChemokine receptorsCell extravasationInflammatory cytokinesReceptor activationCerebrospinal fluidCCR6ChemokinesMultiple sclerosisEnhanced expression
2024
Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups
Olkowski C, Basuli F, Fernandes B, Ghaemi B, Shi J, Zhang H, Farber J, Escorcia F, Choyke P, Jacobson O. Comparative Kidney Uptake of Nanobody-Based PET Tracers Labeled with Various Fluorine-18-Labeled Prosthetic Groups. Molecular Pharmaceutics 2024, 22: 533-543. PMID: 39680709, DOI: 10.1021/acs.molpharmaceut.4c01101.Peer-Reviewed Original ResearchCxcl10 is protective during mouse-adapted SARS-CoV-2 infection
Majumdar S, Weaver J, Pontejo S, Minai M, Lu X, Gao J, Holmes G, Johnson R, Zhang H, Kelsall B, Farber J, Alves D, Murphy P. Cxcl10 is protective during mouse-adapted SARS-CoV-2 infection. Journal Of Leukocyte Biology 2024, 117: qiae252. PMID: 39607906, PMCID: PMC11953068, DOI: 10.1093/jleuko/qiae252.Peer-Reviewed Original ResearchSARS-CoV-2 infectionSARS-CoV-2Mouse-adapted strain of SARS-CoV-2Absence of CXCL10Associated with poor outcomesCXCL10-/- miceLungs of male miceInflammatory gene inductionAcute SARS-CoV-2 infectionMouse-adapted strainSevere COVID-19Wild type controlsCXCL10-deficientChemokine CXCL10Lymphocytic infiltrationSevere acute respiratory syndrome coronavirus 2Poor outcomeAcute respiratory syndrome coronavirus 2Circulating LevelsMale miceRespiratory syndrome coronavirus 2Infected miceSARS-CoV-2 pathogenesisVirus loadCXCL10
2004
Migration of T Cell Progenitors in the Thymus
Uehara S, Farber J, Love P. Migration of T Cell Progenitors in the Thymus. Anti-Inflammatory & Anti-Allergy Agents In Medicinal Chemistry 2004, 3: 313-319. DOI: 10.2174/1568014043355276.Peer-Reviewed Original Research
1996
Interferon-γ and Management of Infectious Diseases
Holland S, Farber J, Gallin J. Interferon-γ and Management of Infectious Diseases. Annals Of Internal Medicine 1996, 124: 1095-1096. DOI: 10.7326/0003-4819-124-12-199606150-00016.Peer-Reviewed Original Research
1992
A Collection of mRNA Species That Are Inducible in the RAW 264.7 Mouse Macrophage Cell Line by Gamma Interferon and Other Agents
Farber J. A Collection of mRNA Species That Are Inducible in the RAW 264.7 Mouse Macrophage Cell Line by Gamma Interferon and Other Agents. Molecular And Cellular Biology 1992, 12: 1535-1545. DOI: 10.1128/mcb.12.4.1535-1545.1992.Peer-Reviewed Original ResearchNonrepetitive sequencesCDNA libraryMouse macrophage cell lineRAW 264.7 mouse macrophage cell lineCrg-1MRNA speciesFamily of interferon-inducible genesMouse chromosome 1Macrophage cell lineCell linesInterferon-inducible genesCDNA clonesRepetitive elementsPlaque hybridizationPublished sequencesChromosome 1Phorbol 12-myristate 13-acetateCDNATranscription factor IRF-1Signaling pathwayGenesIRF-1LRF-1SequenceCalcium ionophore A23187