Phillip Chan, MBChB, PhD, MRCP

Associate Research Scientist

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Appointments

Neurology

Primary

Contact Info

pc639@yale.edu

About

Titles

Associate Research Scientist

Biography

Dr Chan obtained his medical degree at the Chinese University of Hong Kong. He completed his fellowship training in internal medicine and neurology at the Queen Elizabeth Hospital of Hong Kong. Before joining the Yale School of Medicine, he served as a research fellow for NeuroHIV projects conducted in Bangkok, Thailand. He completed his PhD in neurological impacts of acute HIV infection at the University of Amsterdam in 2021. Between 2018 and 2022, he also worked with the Hong Kong University of Science and Technology on neurodegenerative disease research projects.

Last Updated on June 06, 2025.

Appointments

Neurology
Associate Research Scientist
Primary
Neurology

Center for Brain & Mind Health
Neurological Infections and Global Neurology
Neurology
Spudich Lab

Education & Training

PhD: University of Amsterdam (2021)

Higher Physician Trainee (Advanced Internal Medicine): Queen Elizabeth Hospital

Higher Physician Trainee (Neurology): Queen Elizabeth Hospital

Basic Physician Trainee: Queen Elizabeth Hospital

MBChB: The Chinese University of Hong Kong (2004)

Advanced Training & Certifications

Membership of the Royal Colleges of Physicians (UK): Queen Elizabeth Hospital (2008)

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Research

Overview

Medical Research Interests

AIDS Dementia Complex; Biomarkers; Cerebrospinal Fluid; Neurocognitive Disorders; Neurodegenerative Diseases; Neuroimaging

Public Health Interests

Aging; HIV/AIDS; Infectious Diseases; Mental Health

ORCID
0000-0002-4071-4409

Research at a Glance

Yale Co-Authors

Frequent collaborators of Phillip Chan's published research.

Publications

2026

Long-Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection.
Holroyd KB, Hamby T, Sacdalan C, Sriplienchan S, Promensa P, Poonpitak L, Dumrongpisutikul N, Kroon E, Vasan S, Paul R, O'Campo F, Trautmann L, Chan P, Spudich S, RV254/SEARCH 010 Study Team. Long-Term Neurologic Exam Findings in People Diagnosed and Treated During Acute HIV Infection. Ann Clin Transl Neurol 2026 PMID: 42362485, DOI: 10.1002/acn3.70467.
Peer-Reviewed Original Research
Real‐world clinical and laboratory changes after switching to two‐drug regimen in HIV‐suppressed individuals: 48 weeks and beyond
Tang T, Kwong R, Chan P, Lam K, Chan H, Chu M, Lam W, Wu T, Leung W, Yung S, Ting W, Choy A, Tung J, Fong J, Yeung D, Lee M. Real‐world clinical and laboratory changes after switching to two‐drug regimen in HIV‐suppressed individuals: 48 weeks and beyond. HIV Medicine 2026 PMID: 42082362, DOI: 10.1111/hiv.70247.
Peer-Reviewed Original Research
CROI 2026: Neuro-HIV at the Crossroads of Coinfections, Reservoirs, Antiretroviral Therapy, and Comorbidities.
Corley MJ, Joseph SB, Chan P. CROI 2026: Neuro-HIV at the Crossroads of Coinfections, Reservoirs, Antiretroviral Therapy, and Comorbidities. Top Antivir Med 2026, 34: 449-455. PMID: 42127254.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

2025

A psychometric assessment of the Patient Health Questionnaire-9 for people living with acutely-treated HIV in Thailand
Hamby T, Pinyakorn S, Frndak S, Chomchey N, Kanaprach R, Chan P, Schluck G, Kroon E, Suttichom D, Poonpitak L, Sriplienchan S, Spudich S, Phanuphak N, Trautmann L, Paul R, Sacdalan C, Crowell T, Group T. A psychometric assessment of the Patient Health Questionnaire-9 for people living with acutely-treated HIV in Thailand. Psychiatry Research Communications 2025, 6: 100242. PMID: 42369326, PMCID: PMC13308563, DOI: 10.1016/j.psycom.2025.100242.
Peer-Reviewed Original Research
Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy
Chan P, Sacdalan C, Pinyakorn S, Kroon E, Colby D, Promsena P, Sriplienchan S, Phanuphak N, Vasan S, Valcour V, Paul R, Gisslén M, Zetterberg H, Trautmann L, Spudich S. Neuroaxonal Injury in Acute HIV Infection and Following Immediate Antiretroviral Therapy. Journal Of Infectious Diseases 2025, 233: e913-e922. PMID: 41254882, PMCID: PMC13127774, DOI: 10.1093/infdis/jiaf583.
Peer-Reviewed Original Research
Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 105: e214445. PMID: 41172230, PMCID: PMC12817266, DOI: 10.1212/wnl.0000000000214445.
Commentaries, Editorials and Letters
Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection
Chan P, Moreland S, Sacdalan C, Colby D, Ocampo F, Promsena P, Sriplienchan S, Wattana J, Intasan J, Phanuphak N, Vasan S, Paul R, Trautmann L, Spudich S, Kroon E, Team T. Blood pressure and metabolic outcomes after efavirenz‐ or dolutegravir‐based therapy started in acute HIV infection. HIV Medicine 2025, 26: 1619-1625. PMID: 41047593, PMCID: PMC13157706, DOI: 10.1111/hiv.70085.
Peer-Reviewed Original Research
Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy
Chavez J, Bolzenius J, Chan P, Cho K, Mannarino J, Sacdalan C, Farhadian S, Trautmann L, Ndhlovu L, Tipsuk S, Crowell T, Krebs S, Slike B, Suttichom D, Colby D, Phanuphak N, Kroon E, Vasan S, Sriplienchan S, Spudich S, Paul R, Carrico A. Inside out: TNFa-RII and sexualized drug use in acute HIV predicts persistent depressive symptoms despite antiretroviral therapy. Brain Behavior & Immunity - Health 2025, 48: 101079. PMID: 40808976, PMCID: PMC12345309, DOI: 10.1016/j.bbih.2025.101079.
Peer-Reviewed Original Research
CROI 2025: neuropsychiatric complications in people with HIV.
Corley M, Chan P, Joseph S. CROI 2025: neuropsychiatric complications in people with HIV. Topics In Antiviral Medicine 2025, 33: 483-493. PMID: 40472384.
Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
MeSH Keywords
Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV
Holroyd K, Chan P, Sacdalan C, Dumrongpisutikul N, Sriplienchan S, Promensa P, Sailasuta P, Pothisri M, Puttamaswin S, Vasan S, Valcour V, Trautmann L, Spudich S, Paul R, Bolzenius J, Team A. Greater Accumulation of Brain White Matter Hyperintensities in People Diagnosed and Treated During Acute HIV Compared With People Without HIV. Neurology 2025, 104: e213591. PMID: 40327828, PMCID: PMC12060792, DOI: 10.1212/wnl.0000000000213591.
Peer-Reviewed Original Research
MeSH Keywords

See All Publications

Clinical Trials

Current Trials

Volunteers Needed for HIV & Health Study (HARC Plus)
IRB ID1502015318RoleSub InvestigatorPrimary Completion Date06/01/2025
Recruiting Participants
COVID-19Infectious DiseaseHIV/AIDSBrain, Spinal Cord & Nervous System

Academic Achievements & Community Involvement

Activities

activity
Scientific Committee, Asia Pacific AIDS & Co-infections Conference (APACC)
2019 - PresentPeer Review Groups and Grant Study SectionsAbstract Grader
activity
International AIDS Society (IAS) Conference on HIV Science
2022 - PresentPeer Review Groups and Grant Study SectionsAbstract Grader
activity
Royal Colleges of Physicians (UK)
2008 - PresentProfessional OrganizationsMember
activity
Hong Kong College of Physicians (Neurology)
2011 - PresentProfessional OrganizationsFellow
activity
Hong Kong Academy of Medicine (Medicine)
2012 - PresentProfessional OrganizationsFellow

View full list of activities

Honors

honor
Patterson Trust Mentored Research Award
01/31/2023Regional Award
Details
honor
Research Fund 2019-20, the Hong Kong Neurological Society
01/07/2020Regional AwardThe Hong Kong Neurological Society
Details
honor
Young Fellowship Program
06/27/2019International AwardAsia Pacific AIDS & Co-infections Conference (APACC)
Details
honor
Young Investigator Scholarship
02/13/2017Other AwardConference on Retroviruses and Opportunistic Infections (CROI) 2017
Details

News

June 24, 2026
YBII Pilot Grant Awardees - Spring 2026
Read moreabout YBII Pilot Grant Awardees - Spring 2026

Get In Touch

Contacts

pc639@yale.edu

Events

Sep 202630Wednesday

Yale Only
4:00 PM5:00 PM
Phillip Chan, MBChB, PhD, MRCP
Neurology Grand Rounds
From Acute Infection to the Aging Brain: CNS Outcomes Across the HIV Care Continuum
Brady Memorial Laboratory
Join on in person or on Zoom
https://yale.zoom.us/j/94946401346?pwd=yFMfGaIdnqHM1711tEjQExvAQkTElY.1
Add event to Calendar

Appointments

Contact Info

Titles

Biography

Appointments

Neurology

Other Departments & Organizations

Education & Training

Advanced Training & Certifications

Overview

Medical Research Interests

Public Health Interests

ORCID

Research at a Glance

Yale Co-Authors

Serena Susan Spudich, MD, MA

Payal Patel

Brinda Emu, MD

Fangyong Li, MS, MPH

Mehran M Sadeghi, MD

Shelli Farhadian, MD, PhD

Publications

2026

2025

Clinical Trials

Current Trials

Activities

Scientific Committee, Asia Pacific AIDS & Co-infections Conference (APACC)

International AIDS Society (IAS) Conference on HIV Science

Royal Colleges of Physicians (UK)

Hong Kong College of Physicians (Neurology)

Hong Kong Academy of Medicine (Medicine)

Honors

Patterson Trust Mentored Research Award

Research Fund 2019-20, the Hong Kong Neurological Society

Young Fellowship Program

Young Investigator Scholarship

News

YBII Pilot Grant Awardees - Spring 2026

Contacts

Events

Neurology Grand Rounds