Jessica Magid-Bernstein, MD, PhD
Assistant Professor of NeurologyDownloadHi-Res Photo
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Appointments
Neurology
Primary
Publications Overview
- 24 Publications
- 787 Citations
- 18 Yale Co-Authors
About
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Titles
Assistant Professor of Neurology
Biography
Dr. Magid-Bernstein completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Last Updated on October 02, 2023.
Appointments
Neurology
Assistant ProfessorPrimary
Other Departments & Organizations
- Center for Brain & Mind Health
- Janeway Society
- Magid-Bernstein Lab
- Neurocritical Care & Emergency Surgery
- Neurology
- Yale Medicine
Education & Training
- Fellow
- NY Presbyterian - Columbia University Medical Center/Weill Cornell Medicine (2021)
- Resident
- NY Presbyterian - Columbia University Medical Center (2019)
- Intern
- NY Presbyterian - Columbia University Medical Center (2016)
- MD
- Rutgers University - New Jersey Medical School (2015)
- PhD
- University of Medicine and Dentistry of NJ - New Jersey Medical School (2013)
- BA
- Haverford College (2006)
Research
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Overview
Medical Research Interests
Cerebral Intraventricular Hemorrhage; Inflammation; Intracranial Hemorrhages; Subarachnoid Hemorrhage
ORCID
0000-0001-6506-6017- View Lab Website
Magid-Bernstein lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Jessica Magid-Bernstein's published research.
Publications Timeline
A big-picture view of Jessica Magid-Bernstein's research output by year.
Research Interests
Research topics Jessica Magid-Bernstein is interested in exploring.
Kevin Sheth, MD
Guido J. Falcone, MD, ScD, MPH
Lauren Hachmann Sansing, MD, MS, FAHA, FANA
Adam de Havenon, MD, MSCI
Charles Matouk, MD
Emily J. Gilmore, MD, FNCS, FACNS
24Publications
787Citations
Subarachnoid Hemorrhage
Publications
Featured Publications
Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions
Magid-Bernstein J, Girard R, Polster S, Srinath A, Romanos S, Awad IA, Sansing LH. Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions. Circulation Research 2022, 130: 1204-1229. PMID: 35420918, PMCID: PMC10032582, DOI: 10.1161/circresaha.121.319949.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMechanism of injuryIntracerebral hemorrhageUltra-early hemostatic therapyInflammatory brain injuryCurrent treatment strategiesIron-induced injuryAnticoagulant useHemostatic therapyHemorrhagic strokeHypertension managementICH therapySurgical managementHigh morbidityPrimary preventionFunctional outcomeICH managementBrain injuryClinical trialsTreatment strategiesPrognostic biomarkerDevastating formDisease pathobiologyInjuryInvasive surgeryOxidative stressImpacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage
Magid-Bernstein J, Beaman CB, Carvalho-Poyraz F, Boehme A, Hod EA, Francis RO, Elkind MSV, Agarwal S, Park S, Claassen J, Connolly ES, Roh D. Impacts of ABO-incompatible platelet transfusions on platelet recovery and outcomes after intracerebral hemorrhage. Blood 2021, 137: 2699-2703. PMID: 33649761, PMCID: PMC9635530, DOI: 10.1182/blood.2020008381.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsABO-incompatible platelet transfusionsIntracerebral hemorrhagePlatelet transfusionsPlatelet recoveryABO-compatible transfusionsSingle-center cohortOdds of mortalityABO-incompatible transfusionLow platelet recoveryNeurological outcomeOngoing bleedingABO compatibilityICH outcomeMedication effectsTransfusionPoor mRSPatientsHemorrhageOutcomesUnderlying mechanismFurther investigationBleedingCohortMortalityRecoveryCerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials
Magid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSmaller ICH volumeCerebral microbleedsSmall vessel diseaseIntracerebral hemorrhageHematoma expansionHematoma characteristicsICH volumeVessel diseaseNumber of CMBsSmaller baseline hematoma volumesUnderlying small vessel diseasePresence of CMBsCerebral small vessel diseaseAdmission ICH volumeMISTIE III trialPresence of microbleedsClass II evidencePhase 3 trialSeverity of leukoaraiosisPrimary intracerebral hemorrhageBaseline hematoma volumeIndividual patient dataBrain MRI scansLogistic regression modelsAntihypertensive treatmentEarly CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement
Magid-Bernstein J, Yan J, Herman A, He Z, Johnson C, Beatty H, Choi R, Velazquez S, Sorensen G, Jayasundara S, Grychowski L, Amllay A, Falcone G, Kim J, Petersen N, O’Keefe L, Gilmore E, Matouk C, Sheth K, Sansing L. Early CSF inflammatory markers after aneurysmal subarachnoid hemorrhage and their relationship to disease severity and shunt placement. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108395. PMID: 40639751, PMCID: PMC12333380, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108395.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsPermanent shunt placementAneurysmal subarachnoid hemorrhage patientsGranulocyte-colony stimulating factorAneurysmal subarachnoid hemorrhageVascular endothelial growth factorCC motif chemokine ligand 2Shunt placementCerebrospinal fluidCerebrospinal fluid samplesInterleukin-6Interleukin-8Disease severityPreclinical modelsSubarachnoid hemorrhageModified Fisher scale scoresModels of CNS inflammationShunt-dependent hydrocephalusAssociated with clinical severityConcentrations of interleukin-6Post-hemorrhagic hydrocephalusMotif chemokine ligand 2Panel of cytokinesCSF inflammatory markersEndothelial growth factorCerebrospinal fluid concentrationsOperationalizing a complex acute clinical trial: Lessons from the BEACH study
Sorensen G, Remillard W, Schlechter M, Kampp M, Brady C, Kildahl K, Mould A, Ziai W, Lane K, Van Eldik L, Distasio A, Lu J, Sansing L, Hanley D, Magid-Bernstein J. Operationalizing a complex acute clinical trial: Lessons from the BEACH study. Journal Of Clinical And Translational Science 2025, 9: e215. DOI: 10.1017/cts.2025.10152.Peer-Reviewed Original ResearchConceptsNeuroscience intensive care unitPatient careYale-New Haven HospitalCare delivery teamPatient care environmentInterdisciplinary collaborationPatient safetyCare environmentDelivery teamSchool of MedicineClinical trial protocolsUniversity School of MedicineIntracerebral hemorrhageIntensive care unitPatient outcomesCareMultidisciplinary collaborationTrial protocolResearch teamNew Haven HospitalCare unitPatient enrollmentSignals of efficacyYale University School of MedicineInnovative treatment strategies
2025
Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage
Stoehr K, Bartolome D, Jayasundara S, Thinzar P, Vargas D, Kim J, Magid-Bernstein J, O’Keefe L, de Havenon A, Hebert R, Matouk C, Sheth K, Gilmore E, Ortega-Gutierrez S, Petersen N. Impact of Nimodipine-Induced Blood Pressure Reductions on Cerebral Autoregulation and Functional Outcome After Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2025, 1-11. PMID: 40847251, DOI: 10.1007/s12028-025-02338-6.Peer-Reviewed Original ResearchAltmetricConceptsAneurysmal subarachnoid hemorrhageMean arterial pressureAssociated with worse functional outcomeBP reductionFunctional outcomesNimodipine administrationSubarachnoid hemorrhageHunt & Hess scoreBlood pressureAssociated with BP reductionSevere aneurysmal subarachnoid hemorrhageModified Fisher gradeResponse to nimodipineSensitive to nimodipineCerebral autoregulationDelayed Cerebral IschemiaBlood pressure reductionRegional oxygen saturationObservational cohort studyModified Rankin ScaleLimits of autoregulationFisher gradeHess scoreAneurysm securementNeurological outcomeDo the Benefits of Blood Pressure Control in ICH Outweigh the Risks?
Magid-Bernstein J, Murthy S. Do the Benefits of Blood Pressure Control in ICH Outweigh the Risks? JAMA Neurology 2025, 82: 541-542. PMID: 40257789, DOI: 10.1001/jamaneurol.2025.0238.Peer-Reviewed Original ResearchAltmetric
2024
Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage
Rivier C, Renedo D, Marini S, Magid‐Bernstein J, de Havenon A, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Sex Modifies the Severity and Outcome of Spontaneous Intracerebral Hemorrhage. Annals Of Neurology 2024, 97: 232-241. PMID: 39499118, DOI: 10.1002/ana.27123.Peer-Reviewed Original ResearchCitationsAltmetricConceptsRisk of hematoma expansionHighest risk of hematoma expansionRisk of poor outcomesIntracerebral hemorrhageHematoma expansionHigh riskMale sexPoor outcomeOutcome of spontaneous intracerebral hemorrhageClinical characteristics of patientsStudies of intracerebral hemorrhageNon-traumatic intracerebral hemorrhageIndividual Patient Data Meta-AnalysisPatient data meta-analysisSpontaneous intracerebral hemorrhageSingle-center studyIntracerebral hemorrhage patientsHigh risk of expansionCharacteristics of patientsIntracerebral hemorrhage severityPoor functional outcomeRandomized clinical trialsData Meta-AnalysisHemorrhage volumeClinical characteristics
2023
Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage
Parasram M, Park J, Al-Dulaimi M, Magid-Bernstein J. Guidelines in Action: Management of Acute and Chronic Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage. Stroke 2023, 54: e508-e511. PMID: 37842781, DOI: 10.1161/strokeaha.123.044793.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsAcute and subacute neurovascular impact of cryptogenic air emboli
Gummerson C, Parasram M, Peng T, Picard J, Kahn P, Angelus E, Bhatt S, de Havenon A, Jasne A, Magid-Bernstein J. Acute and subacute neurovascular impact of cryptogenic air emboli. Surgical Neurology International 2023, 14: 285. PMID: 37680929, PMCID: PMC10481802, DOI: 10.25259/sni_382_2023.Peer-Reviewed Case Reports and Technical NotesCitationsConceptsMagnetic resonance imagingCortical diffusion restrictionAir emboliMiddle cerebral artery territoryRight anterior cerebral arterySubsequent magnetic resonance imagingDiffusion restrictionClose neurologic monitoringNeurocritical care managementCerebral air embolismAcute ischemic strokeAnterior cerebral arteryInitial radiographic findingsCerebral air emboliType of injuryComputerized tomography scanCourse of careArtery territoryCerebral edemaIschemic strokeNeurologic monitoringCerebral arteryCortical veinsInitial imagingMechanical ventilation
Clinical Trials
Current Trials
Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
HIC ID2000031665RolePrincipal InvestigatorPrimary Completion Date12/01/2025Recruiting ParticipantsGenderBothAge18+ yearsBrain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
HIC ID2000024956RoleSub InvestigatorPrimary Completion Date07/01/2023Recruiting ParticipantsGenderBothAge14+ yearsAnticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
HIC ID2000026409RoleSub InvestigatorPrimary Completion Date04/30/2028Recruiting ParticipantsGenderBothAge18+ years
Academic Achievements & Community Involvement
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Activities
activity BMC Neurology
2020 - PresentJournal ServiceRevieweractivity Hypertension
2020 - PresentJournal ServiceRevieweractivity Neurohospitalst
2020 - PresentJournal ServiceRevieweractivity Neurocritical Care
2021 - PresentJournal ServiceRevieweractivity Journal of the American Heart Association
2020 - PresentJournal ServiceReviewer
Honors
honor American Neurological Association Emerging Scholar Award candidate
09/13/2024National AwardAmerican Neurological AssociationDetailsUnited Stateshonor American Neurologic Association Annual Meeting travel grant
10/22/2022National AwardAmerican Neurological Associationhonor American Neurological Association Emerging Scholar Award candidate
10/22/2022National AwardAmerican Neurological Associationhonor Neurocritical Care Society travel grant
09/22/2020International AwardNeurocritical Care SocietyDetailsUnited Stateshonor AOA Honor Medical Society member
08/01/2015National AwardDetailsUnited States
Clinical Care
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Overview
Jessica Magid-Bernstein, MD, PhD, completed her MD and PhD with a focus in immunology at Rutgers University – New Jersey Medical School in Newark, NJ, in 2015. She then went on to complete her medical internship and residency training in Neurology at New York Presbyterian – Columbia University Medical Center, followed by a fellowship in Neurocritical Care at New York Presbyterian – Columbia University Medical Center & Weill Cornell Medicine before joining the Yale Department of Neurology Division of Neurocritical Care and Emergency Neurology in 2021.
Dr. Magid-Bernstein is dedicated to taking care of complex neurocritically ill patients during her clinical time in the NeuroICU at Yale. When she is not on clinical service, she is developing a research career focused on understanding the role that inflammation plays in outcomes following intracerebral hemorrhage and subarachnoid hemorrhage.
Clinical Specialties
Neurology; Neurocritical Care
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Locations
Yale Neurology
Academic Office
100 York Street, Ste Suite 1N
New Haven, CT 06511