Patrick Worhunsky, DPhil

2026

• Associations between dopaminergic and serotonergic systems in individuals with cocaine use disorder: An exploratory analysis of [¹¹C]PHNO and [¹¹C]P943 PET imaging

  Cayir S, Ysrayl B, Sotomayor-Carreño E, Hurtado A, Potenza M, Carson R, Matuskey D, Angarita G, Worhunsky P. Associations between dopaminergic and serotonergic systems in individuals with cocaine use disorder: An exploratory analysis of [¹¹C]PHNO and [¹¹C]P943 PET imaging. Drug And Alcohol Dependence 2026, 287: 113329. PMID: 42685387, DOI: 10.1016/j.drugalcdep.2026.113329.

  Peer-Reviewed Original Research

  MeSH Keywords

• Neuromodulation in Alzheimer’s disease: a review with illustrative pilot data using focused ultrasound

  Haut M, Vieira Ligo Teixeira C, Ranjan M, Carpenter J, Mehta R, Worhunsky P, D'Haese P, Arsiwala T, Everson K, Suffridge J, Keith C, Phelps H, Ebbert M, Finomore V, Rezai A. Neuromodulation in Alzheimer’s disease: a review with illustrative pilot data using focused ultrasound. Biological Psychiatry 2026 PMID: 42532278, DOI: 10.1016/j.biopsych.2026.07.019.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

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• Episodic memory and associated cortical atrophy in amnestic early-onset and late-onset Alzheimer's disease

  Keith C, Haut M, Worhunsky P, Teixeira C, Mehta R, Malone J, Phelps H, Ward M, Miller M, Pockl S, Rajabalee N, Marano G, McCuddy W, D'Haese P, Rezai A. Episodic memory and associated cortical atrophy in amnestic early-onset and late-onset Alzheimer's disease. Journal Of Alzheimer’s Disease 2026, 113: 403-413. PMID: 42489442, PMCID: PMC13499921, DOI: 10.1177/13872877261469183.

  Peer-Reviewed Original Research

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  MeSH Keywords

• Retinal thickness is associated with global cognition and executive function in mild cognitive impairment due to Alzheimer's disease

  Amireskandari A, Vieira Ligo Teixeira C, Worhunsky P, Keith C, Malone J, Ward M, Haut M, Realini T, Finomore V, Rezai A. Retinal thickness is associated with global cognition and executive function in mild cognitive impairment due to Alzheimer's disease. Journal Of Alzheimer's Disease Reports 2026, 10 DOI: 10.1177/25424823261472085.

  Peer-Reviewed Original Research

• Anti‐amyloid immunotherapy and brain volume trajectories in early‐onset versus late‐onset Alzheimer's disease

  Mehta R, Jaisa‐aad M, Teixeira C, Worhunsky P, Malone J, Ward M, Keith C, Phelps H, Sharif K, Pockl S, Rajabalee N, Marano G, Bojarski L, Smith S, Massey K, Hatfield M, D'Haese P, Rezai A, Haut M. Anti‐amyloid immunotherapy and brain volume trajectories in early‐onset versus late‐onset Alzheimer's disease. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2026, 18: e70457. PMID: 42633124, PMCID: PMC13499008, DOI: 10.1002/dad2.70457.

  Peer-Reviewed Original Research

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• Widespread synaptic density loss in schizophrenia follows molecular and network architecture

  Chopra S, Worhunsky P, Naganawa M, Zhang X, Segal A, Labache L, Orchard E, Cropley V, Wood S, Angarita G, Cosgrove K, Matuskey D, Nabulsi N, Huang Y, Carson R, Esterlis I, D’Souza D, Holmes A, Radhakrishnan R. Widespread synaptic density loss in schizophrenia follows molecular and network architecture. Molecular Psychiatry 2026, 1-12. PMID: 42350786, DOI: 10.1038/s41380-026-03717-x.

  Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements

  Citations

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• Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study

  Mayeli M, Worhunsky P, Carson R, Potenza M, Angarita G, Matuskey D. Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study. Psychiatry Research 2026, 364: 117239. PMID: 42229023, DOI: 10.1016/j.psychres.2026.117239.

  Peer-Reviewed Original Research

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• Neuroimaging as the ‘missing link’ for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment

  Birney S, Cheng A, Babuscio T, Dwy S, Orazietti S, Worhunsky P, Shi J, Sofuoglu M, Constable T, Potenza M, Carroll K, Yip S. Neuroimaging as the ‘missing link’ for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment. Psychopharmacology 2026, 1-12. PMID: 42108273, DOI: 10.1007/s00213-026-07071-2.

  Peer-Reviewed Original Research

• Generation of brain PET synaptic density imaging from MRI and FDG-PET using a 3D Multi-stage Residual U-Net

  Zheng X, Worhunsky P, Toyonaga T, Liu Q, Guo X, Zhou Y, Chen X, Zhou B, Mecca A, Chen M, O'Dell R, Van Dyck C, Carson R, Radhakrishnan R, Liu C. Generation of brain PET synaptic density imaging from MRI and FDG-PET using a 3D Multi-stage Residual U-Net. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3690934.

  Peer-Reviewed Original Research

• Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies

  Haut M, Teixeira C, Worhunsky P, Mehta R, Malone J, Ward M, Keith C, Phelps H, Pockl S, Rajabalee N, Sharif K, Marano G, D'Haese P, Rezai A. Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies. The Journal Of Prevention Of Alzheimer's Disease 2026, 13: 100519. PMID: 41763101, PMCID: PMC12966669, DOI: 10.1016/j.tjpad.2026.100519.

  Peer-Reviewed Original Research

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