Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsPatrick Worhunsky, DPhil
Assistant Professor Adjunct in PsychiatryAbout
Research
Publications
2026
Widespread synaptic density loss in schizophrenia follows molecular and network architecture
Chopra S, Worhunsky P, Naganawa M, Zhang X, Segal A, Labache L, Orchard E, Cropley V, Wood S, Angarita G, Cosgrove K, Matuskey D, Nabulsi N, Huang Y, Carson R, Esterlis I, Skosnik P, D’Souza D, Holmes A, Radhakrishnan R. Widespread synaptic density loss in schizophrenia follows molecular and network architecture. Molecular Psychiatry 2026, 1-12. PMID: 42350786, DOI: 10.1038/s41380-026-03717-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsImpulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study
Mayeli M, Worhunsky P, Carson R, Potenza M, Angarita G, Matuskey D. Impulsivity, reward sensitivity, and dopamine 2/3 receptors availability in people with cocaine use disorder: A [11C]PHNO PET study. Psychiatry Research 2026, 364: 117239. PMID: 42229023, DOI: 10.1016/j.psychres.2026.117239.Peer-Reviewed Original ResearchNeuroimaging as the ‘missing link’ for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment
Birney S, Cheng A, Babuscio T, Dwy S, Orazietti S, Worhunsky P, Shi J, Sofuoglu M, Constable T, Potenza M, Carroll K, Yip S. Neuroimaging as the ‘missing link’ for preclinical to clinical translation: an example using N-acetylcysteine among individuals with cocaine- and opioid-use disorders receiving methadone treatment. Psychopharmacology 2026, 1-12. PMID: 42108273, DOI: 10.1007/s00213-026-07071-2.Peer-Reviewed Original ResearchGeneration of brain PET synaptic density imaging from MRI and FDG-PET using a 3D Multi-stage Residual U-Net
Zheng X, Worhunsky P, Toyonaga T, Liu Q, Guo X, Zhou Y, Chen X, Zhou B, Mecca A, Chen M, O'Dell R, Van Dyck C, Carson R, Radhakrishnan R, Liu C. Generation of brain PET synaptic density imaging from MRI and FDG-PET using a 3D Multi-stage Residual U-Net. IEEE Transactions On Radiation And Plasma Medical Sciences 2026, PP: 1-1. DOI: 10.1109/trpms.2026.3690934.Peer-Reviewed Original ResearchMemory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies
Haut M, Teixeira C, Worhunsky P, Mehta R, Malone J, Ward M, Keith C, Phelps H, Pockl S, Rajabalee N, Sharif K, Marano G, D'Haese P, Rezai A. Memory Consolidation and ARIA in Individuals Receiving Anti-amyloid Monoclonal Antibodies. The Journal Of Prevention Of Alzheimer's Disease 2026, 13: 100519. PMID: 41763101, PMCID: PMC12966669, DOI: 10.1016/j.tjpad.2026.100519.Peer-Reviewed Original Research
2025
Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning
Zheng X, Worhunsky P, Liu Q, Guo X, Chen X, Sun H, Zhang J, Toyonaga T, Mecca A, O’Dell R, van Dyck C, Angarita G, Cosgrove K, D’Souza D, Matuskey D, Esterlis I, Carson R, Radhakrishnan R, Liu C. Generating synthetic brain PET images of synaptic density based on MR T1 images using deep learning. EJNMMI Physics 2025, 12: 30. PMID: 40163154, PMCID: PMC11958861, DOI: 10.1186/s40658-025-00744-5.Peer-Reviewed Original ResearchInteraction of insula and hippocampus in memory dysfunction in Alzheimer's disease
Coleman M, Haut M, Teixeira C, Keith C, Mehta R, Phelps H, Worhunsky P, Ward M, Malone J, Miller M, Navia R, Marano G, Pockl S, Rajabalee N, McCuddy W, D’Haese P, Rezai A, Wilhelmsen K. Interaction of insula and hippocampus in memory dysfunction in Alzheimer's disease. Journal Of Alzheimer's Disease Reports 2025, 9: 25424823251407323. PMID: 41473353, PMCID: PMC12745511, DOI: 10.1177/25424823251407323.Peer-Reviewed Original Research
2024
The early-onset Alzheimer’s disease MRI signature: a replication and extension analysis in early-stage AD
Mehta R, Keith C, Teixeira C, Worhunsky P, Phelps H, Ward M, Miller M, Navia R, Pockl S, Rajabalee N, Coleman M, D’Haese P, Rezai A, Wilhelmsen K, Haut M. The early-onset Alzheimer’s disease MRI signature: a replication and extension analysis in early-stage AD. Cerebral Cortex 2024, 34: bhae475. PMID: 39714256, PMCID: PMC11664631, DOI: 10.1093/cercor/bhae475.Peer-Reviewed Original ResearchVitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study
Worhunsky P, Mignosa M, Gallezot J, Pittman B, Nabulsi N, Stryjewski A, Jalilian-Khave L, Trinko R, DiLeone R, Carson R, Malison R, Potenza M, Angarita G. Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study. Biological Psychiatry 2024, 97: 651-658. PMID: 39395473, PMCID: PMC11839384, DOI: 10.1016/j.biopsych.2024.09.028.Peer-Reviewed Original ResearchDeficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original Research
News
News
- July 16, 2026Source: Molecular Psychiatry
Widespread Synaptic Density Loss in Schizophrenia Follows Molecular and Network Architecture
- October 16, 2024Source: Biological Psychiatry
Vitamin D’s Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study