Aaron Wolfe, PhD
Associate Research ScientistAbout
Research
Publications
2025
Real-Time Binding Kinetics of Membrane Protein–Protein Interactions in a Membraneless Setting
Wang Y, Wu Y, Mayse L, Capucilli D, Huang P, Ramachandran S, Luikham S, Ha J, Loh S, Wolfe A, Movileanu L. Real-Time Binding Kinetics of Membrane Protein–Protein Interactions in a Membraneless Setting. Analytical Chemistry 2025, 97: 24849-24858. PMID: 41143522, PMCID: PMC12613146, DOI: 10.1021/acs.analchem.5c05510.Peer-Reviewed Original ResearchConceptsMembrane protein receptorsMembrane proteinsReal-time binding kineticsSurface plasmon resonanceProtein ligandsProtein receptorMembrane protein-protein interactionsExpression host systemsProtein-protein interactionsBiolayer interferometryHigh-affinity interactionHigh-throughput data collectionSignal-to-noise ratioFunctional reconstitutionTransient complexProtein solubilizationLigandProteinMedical biotechnologyPlasmon resonanceProtein analytesSensor surfaceNative membranesProteomicellesLabel-free
2023
Extracellular vimentin is sufficient to promote cell attachment, spreading, and motility by a mechanism involving N-acetyl glucosamine-containing structures
Bucki R, Iwamoto D, Shi X, Kerr K, Byfield F, Suprewicz Ł, Skłodowski K, Sutaria J, Misiak P, Wilczewska A, Ramachandran S, Wolfe A, Thanh M, Whalen E, Patteson A, Janmey P. Extracellular vimentin is sufficient to promote cell attachment, spreading, and motility by a mechanism involving N-acetyl glucosamine-containing structures. Journal Of Biological Chemistry 2023, 299: 104963. PMID: 37356720, PMCID: PMC10392088, DOI: 10.1016/j.jbc.2023.104963.Peer-Reviewed Original ResearchConceptsExtracellular vimentinN-acetyl-glucosamineCell typesHyaluronic acid-degrading enzymeGlycosylated cell surface proteinPolyacrylamide hydrogel substratesCell surface proteinsVimentin intermediate filamentsTraction force microscopyCellular functionsSurface of cellsAdhesion receptorsVimentin filamentsSurface proteinsExtracellular environmentSoluble heparinIntermediate filamentsCell adhesionCarbohydrate structuresCell attachmentExtracellular matrixExpansion assayCell membraneExtracellular spaceCellsErratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Simon M, Yang J, Gigas J, Earley E, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen S, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad S, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia B, Robbins P, Vijg J, Seluanov A, Suh Y, Gorbunova V. Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal 2023, 42: embj2022113326. PMID: 36722290, PMCID: PMC9890223, DOI: 10.15252/embj.2022113326.Peer-Reviewed Original Research
2022
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Simon M, Yang J, Gigas J, Earley E, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen S, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad S, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia B, Thomas D, Robbins P, Vijg J, Seluanov A, Suh Y, Gorbunova V. A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A. The EMBO Journal 2022, 41: embj2021110393. PMID: 36215696, PMCID: PMC9627671, DOI: 10.15252/embj.2021110393.Peer-Reviewed Original ResearchConceptsMono-ADP-ribosyl transferasesLamin A/CAshkenazi JewishSirtuin 6DNA double-strand break repairDouble-strand break repairImproving genome maintenanceAJ individualsGenome maintenanceGenome stabilityLINE1 retrotransposonsTarget sequenceBreak repairDeacetylase activityCellular pathwaysNAD+ concentrationMetabolic regulationLamin ACancer cellsKill cancer cellsHuman longevityAllelesRetrotransposonsGenomeDeacylase
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