Xingguang Luo, MD
Associate Research Scientist in PsychiatryCards
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
Appointments
Psychiatry
Primary
Additional Titles
Assistant Professor, Psychiatry
Contact Info
About
Titles
Associate Research Scientist in Psychiatry
Assistant Professor, Psychiatry
Appointments
Psychiatry
Associate Research ScientistPrimary
Other Departments & Organizations
- Division of Human Genetics
- Psychiatry
- Yale Global Mental Health Program
Education & Training
- Assistant Professor (2006-2012)
- Yale University School of Medicine (2012)
- Post-doc (2000-2003)
- Yale University (2003)
- MD
- Shanghai Medical University (2000)
Research
Overview
NIH R01: Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
NIH R21: Deep sequencing of glutamatergic pathway genes in alcohol and nicotine co-dependence
NIH R21: Post-GWAS transcriptome-wide LncRNA profiling in alcoholism
Medical Research Interests
Behavior and Behavior Mechanisms; Mental Disorders; Psychiatry and Psychology
Public Health Interests
Genetics, Genomics, Epigenetics; Substance Use, Addiction; Mental Health
ORCID
0000-0003-3585-042X
Research at a Glance
Yale Co-Authors
Frequent collaborators of Xingguang Luo's published research.
Publications Timeline
A big-picture view of Xingguang Luo's research output by year.
Research Interests
Research topics Xingguang Luo is interested in exploring.
Chiang-Shan Ray Li, MD, PhD
Joel Gelernter, MD
John Krystal, MD
Heping Zhang, PhD
Lingeng Lu, MD, PhD
Bao-Zhu Yang, PhD
189Publications
4,522Citations
Mental Disorders
Publications
2025
Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia
Jiang X, Gou M, Yin Y, Chen W, Li Y, Chen S, Pan S, Luo X, Tan S, Tian B, Li W, Tong J, Wang J, Li H, Yu T, Wang Z, Zhang P, Huang J, Tian L, Kochunov P, Li C, Hong L, Tan Y. Cortisol response patterns to stress correlated to white matter integrity and duration of illness in patients with schizophrenia. Psychoneuroendocrinology 2025, 179: 107501. PMID: 40479922, DOI: 10.1016/j.psyneuen.2025.107501.Peer-Reviewed Original ResearchConceptsCortisol response patternsDuration of illnessDiffusion tensor imagingCortisol levelsWM integrityPositive and Negative Syndrome ScaleResponse to acute stress exposureHC groupPaced Auditory Serial Addition TaskResponse patternsNegative Syndrome ScaleFirst-episode schizophreniaBiomarkers of schizophreniaAcute stress exposureWhite matter integrityWM microstructural integrityWM tract integritySalivary cortisol levelsSyndrome ScaleChronic schizophreniaClinical psychopathologyCortisol reactivitySchizophrenia pathogenesisWhite matterBrain regionsAnalysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage
Luo X, Song K, Zhuo L, Lin F, Gao Z, He Q, Zheng Y, Lian K, Shangguan H, Luo X, Lin Y, Kang D, Fang W. Analysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage. Scientific Reports 2025, 15: 17759. PMID: 40404752, PMCID: PMC12098909, DOI: 10.1038/s41598-025-01754-0.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsHematoma evacuationStereotactic aspirationCatheter drainageStereotactic surgeryRisk factorsHE ratesSpontaneous intracerebral hemorrhageHematoma evacuation rateIndependent risk factorBootstrap internal validationMultivariate logistic analysisPredictive scoring modelROC curve analysisPooled individual dataAUC valuesMultivariate logistic regressionBlend signCutoff valueIntracerebral hemorrhageDrainage tubeInternal validityPrimary outcomeHematoma edgeSurgical efficiencyLogistic analysisAssociation between fish consumption and sleep disorders among Chinese adults: a cross-sectional study
Li S, Ma M, Hu L, Lao J, Luo X, Pan J, Lu D, Wang M, Lin W, Fan Y, Wang F, Chen Y, Wang P, Wu F, Wei X, Xu J, Liu Y, Zheng L. Association between fish consumption and sleep disorders among Chinese adults: a cross-sectional study. Annals Of Medicine 2025, 57: 2491663. PMID: 40254933, PMCID: PMC12013145, DOI: 10.1080/07853890.2025.2491663.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsFish intakeCross-sectional studySleep disordersPittsburgh Sleep Quality IndexInsomnia Severity IndexSleep latencyFood frequency questionnaireLow fish intakePrevalence of sleep disordersWeekly fish intakeLogistic regression analysisSleep qualityAssociated with sleep qualityShorter sleep latencyFrequency questionnaireInfluence of fish consumptionSleep quality scoresSleep Quality IndexFish consumptionChinese adultsDaytime functioningDaytime dysfunctionIntakeSleepSeverity IndexPhenome-wide association studies between SERINC2 and neuropsychiatric disorders
Liu P, Luo X, Cao L, Zhang Y, Ji J, Wang X, Wang K, Pan X, Yang R, Tan Z, Tan Y, Li C, Guo X, Wang Z, Luo X. Phenome-wide association studies between SERINC2 and neuropsychiatric disorders. Frontiers In Psychiatry 2025, 15: 1420395. PMID: 39902246, PMCID: PMC11788846, DOI: 10.3389/fpsyt.2024.1420395.Peer-Reviewed Original ResearchAltmetricConceptsGray matter volumeBipolar disorderNeuropsychiatric disordersDisease-risk alleleSubcortical gray matter volumesSubstance use disordersMRNA expressionCortical surface areaAssociated with alcoholCocaine dependenceMarijuana dependencePolysubstance dependenceMatter volumeNicotine dependenceBrain regionsSchizophreniaSubcortical structuresSNP-disease associationsPhenome-wide association studyAutismOCDFDR correctionDisordersRegulatory effectsAssociation studiesPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structures
2024
Feature Selection and Machine Learning Approaches in Prediction of Current E-Cigarette Use Among U.S. Adults in 2022
Fang W, Liu Y, Xu C, Luo X, Wang K. Feature Selection and Machine Learning Approaches in Prediction of Current E-Cigarette Use Among U.S. Adults in 2022. International Journal Of Environmental Research And Public Health 2024, 21: 1474. PMID: 39595741, PMCID: PMC11594230, DOI: 10.3390/ijerph21111474.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSupport vector machineFeature selectionMachine learningRandom forestCollection of featuresMachine learning approachImbalance dataF1 scoreVector machineML techniquesLearning approachML toolsRelevant featuresPatient Health Questionnaire-4E-cigarette useML modelsML approachesRF algorithmRandom oversampling examplesMachineAlgorithmE-cigarettesSelection operatorLogistic regressionHealth Information National Trends SurveyN-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Tong J, Yang K, Li W, Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Zhao Y, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Tian B, Li C, Hong L, Tan Y. N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 2024, sbae180. PMID: 39406395, DOI: 10.1093/schbul/sbae180.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaSensory gating deficitsN-methyl-D-aspartate receptorsFirst-episode schizophrenia groupGating deficitsN-methyl-D-aspartateP50 ratioSensory gatingExposure to antipsychotic medicationAb levelsHealthy controlsAntipsychotic medication exposureFirst-episode patientsDiagnosis of schizophreniaImpaired sensory gatingP50 sensory gating deficitN-methyl-D-aspartate receptor antibodiesAntipsychotic medicationFirst-episodeNon-smoking healthy controlsP50 differenceSchizophreniaPartial correlation analysisEnzyme-linked immunosorbent assayDeficitsPlasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study
Theeke L, Liu Y, Wang S, Luo X, Navia R, Xiao D, Xu C, Wang K, Initiative T. Plasma Proteomic Biomarkers in Alzheimer’s Disease and Cardiovascular Disease: A Longitudinal Study. International Journal Of Molecular Sciences 2024, 25: 10751. PMID: 39409080, PMCID: PMC11477191, DOI: 10.3390/ijms251910751.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsMild cognitive impairmentLinear mixed modelsAlzheimer's diseaseCardiovascular diseaseAlzheimer's Disease Neuroimaging InitiativeLongitudinal changesAssociated with longitudinal changesAssociation of ADAssociated with ADMultivariate linear mixed modelOlder adultsCardiovascular healthPlasma proteomic biomarkersRisk factorsCognitive declineCognitive impairmentLongitudinal studyProteomic biomarkersTamm-Horsfall proteinMixed modelsThe Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia
Guo X, Luo X, Huang X, Zhang Y, Ji J, Wang X, Wang K, Wang J, Pan X, Chen B, Tan Y, Luo X. The Role of 3’ Regulatory Region Flanking Kinectin 1 Gene in Schizophrenia. ALPHA PSYCHIATRY 2024, 25: 413-420. PMID: 39148597, PMCID: PMC11322729, DOI: 10.5152/alphapsychiatry.2024.241616.Peer-Reviewed Original ResearchCitationsConceptsGray matter volumeAssociated with volumetric reductionsBasal gangliaSuperior frontal cortexDevelopment of schizophreniaSingle-nucleotide polymorphismsRisk of schizophreniaNucleus accumbensFrontal cortexPosterior cingulateMatter volumeInsular cortexBrain areasSchizophreniaSubcortical nucleiVolumetric reductionCortexPutamenCortical areasIndependent samplesRisk allelesSignificance of variantsRegulatory regionsMRNA expressionGenome-wide association studiesMethylome-wide association studies of psychiatric disorders.
Mao Q, Luo Z, Wang X, Wang K, Wang Z, Zhang Y, Luo X. Methylome-wide association studies of psychiatric disorders. EC Psychology And Psychiatry 2024, 2024 PMID: 40171497, PMCID: PMC11960846.Peer-Reviewed Original ResearchConceptsPsychiatric disordersMethylome-wide association studiesTreatment of psychiatric conditionsPsychiatric well-beingAssociation studiesPathological brain functionInform treatment strategiesNeurobiological processesPsychiatric conditionsBrain functionDisordersWell-beingSequencing approachEpigenetic mechanismsBrain tissue samplesMethylomeArray-basedTherapeutic targetNeuroepigeneticsBrainTreatment strategies
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