About
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Associate Research Scientist in Pharmacology
Appointments
Pharmacology
Associate Research ScientistPrimary
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Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Yi Luan's published research.
Fangyong Li, MS, MPH
Richard Pierce, MD
Publications
2022
Correction: Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries.
Luan Y, Yuan Q, Wang Q, Compton S, Wu D, Tang W. Correction: Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries. Journal Of Immunology (Baltimore, Md. : 1950) 2022 PMID: 36207135, DOI: 10.4049/jimmunol.2200656.Peer-Reviewed Original ResearchPazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries.
Luan Y, Yuan Q, Wang Q, Compton S, Wu D, Tang W. Pazopanib Is a Potential Treatment for Coronavirus-Induced Lung Injuries. The Journal Of Immunology 2022, 209: 723-730. PMID: 35914834, PMCID: PMC9378470, DOI: 10.4049/jimmunol.2100968.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLung injuryCOVID-19 patientsPotential treatmentSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Long-term pathological consequencesRespiratory syndrome coronavirus 2Severe acute respiratory syndromeAdministration of pazopanibAmeliorate lung injuryPulmonary disease modelAcute lung injuryEarly disease manifestationsSyndrome coronavirus 2Acute respiratory syndromeCOVID-19Health care systemCoronavirus 2J miceDisease manifestationsTherapeutic effectVirus infectionRespiratory syndromePazopanibInjury
2021
Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3
Yuan Q, Basit A, Liang W, Qu R, Luan Y, Ren C, Li A, Xu X, Liu X, Yang C, Kuo A, Pierce R, Zhang L, Turk B, Hu X, Li F, Cui W, Li R, Huang D, Mo L, Sessa WC, Lee PJ, Kluger Y, Su B, Tang W, He J, Wu D. Pazopanib ameliorates acute lung injuries via inhibition of MAP3K2 and MAP3K3. Science Translational Medicine 2021, 13 PMID: 33910977, PMCID: PMC8466683, DOI: 10.1126/scitranslmed.abc2499.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute lung injuryLung injuryMyeloid cellsLung transplantation recipientsMouse ALI modelPulmonary barrier functionTransplantation recipientsALI modelReactive oxygen species formationPharmacological interventionsPazopanibOxygen species formationVasculature integrityEpithelial cell survivalHigh mortalityMitogen-activated protein kinase kinase kinase 2Barrier functionGenetic inactivationInjuryCell survivalMortalityProtein kinase kinase kinase 2MAP3K3Kinase 2Manifestations
2016
The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens
Sun J, Luan Y, Xiang D, Tan X, Chen H, Deng Q, Zhang J, Chen M, Huang H, Wang W, Niu T, Li W, Peng H, Li S, Li L, Tang W, Li X, Wu D, Wang P. The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens. Cell Reports 2016, 14: 737-749. PMID: 26776519, PMCID: PMC4740229, DOI: 10.1016/j.celrep.2015.12.069.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsToll-like receptorsNF-κB pathwayBacterial infectionsHost defenseNF-κB regulationNF-κBNF-κB transcriptional activityNF-κB-mediated transcriptionBacterial burdenImmune responseTranscriptional activityInnate immunityInfectionHematopoietic cellsBacterial pathogensFeedforward mechanismPSME3MacrophagesHost tissuesNegative regulatorPathwayImmunityReceptors
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