Yang Yang
Research Associate NeurosurgeryCards
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Research
Publications
2026
Reactive oxygen species–resistant ultrastable super-resolution DNA framework dots
Liang C, Li Q, Chen B, Zhai T, Luo X, Yang Y, Qian J, Zhao D, Luo S, Wang F, Li Q, Shen J, Fan C. Reactive oxygen species–resistant ultrastable super-resolution DNA framework dots. Proceedings Of The National Academy Of Sciences Of The United States Of America 2026, 123: e2514438123. PMID: 41730100, PMCID: PMC12956890, DOI: 10.1073/pnas.2514438123.Peer-Reviewed Original ResearchConceptsStructured illumination microscopySuper-resolution imagingSTED imagingSingle-particleShielding effectivenessDNA frameworkSingle-particle trackingDouble-stranded DNAPhysical propertiesCatalytic applicationsDotsLive cell membranesSpatial resolutionPeptide scaffoldsFluorescent probeBarcodingCell membraneGFPInner cavityFluorophoresSTEDHuman microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation
Wu J, Chen X, Zhang J, Wettschurack K, Robinson M, Li W, Zhao Y, Yoo Y, Deming B, Shu Y, Abeyaratna A, Que Z, Du D, Tegtmeyer M, Yuan C, Skarnes W, Zhang Z, Rochet J, Wu L, Yang Y. Human microglia in brain assembloids display region-specific diversity and respond to hyperexcitable neurons carrying SCN2A mutation. Science Advances 2026, 12: eady2977. PMID: 41706855, PMCID: PMC12915608, DOI: 10.1126/sciadv.ady2977.Peer-Reviewed Original ResearchConceptsNeuropsychiatric disordersExcessive synaptic pruningPharmacological inhibitionHuman microgliaSubcortical regionsNeural circuitryNeuronal circuit developmentSynaptic pruningNeural circuitsHuman brainSCN2A mutationsNeuronal hyperactivityNeuroimmune interactionsHyperexcitable neuronsSingle-cell RNA sequencingAutismReceptor geneCalcium signalingMicroglial responseCircuit developmentMicrogliaDisordersGABABrainPathological effectsHarmonizing Generalization and Specialization: Uncertainty-Informed Collaborative Learning for Semi-supervised Medical Image Segmentation
Lu W, Hong Y, Yang Y. Harmonizing Generalization and Specialization: Uncertainty-Informed Collaborative Learning for Semi-supervised Medical Image Segmentation. IEEE Transactions On Medical Imaging 2026, PP: 1-1. PMID: 41697810, DOI: 10.1109/tmi.2026.3664940.Peer-Reviewed Original ResearchMedical image segmentationSemi-supervised medical image segmentationImage segmentationPseudo label learningTask-specific representationsTask-specific requirementsLimited annotationsAnnotation requirementsCollaborative learningSemantic representationAmbiguous regionsSupervised performanceLearningClinical tasksAnnotationPrediction uncertaintyUNCOLRepresentationFoundation modelDiverse 2DFine-grainedGeneralizationLarge-scalePerformanceRequirementsFacilitating creep-resistant Al alloy design through a physics-aware integrated machine learning pipeline
Cao Z, Wang X, He G, Li Y, Yang Y, Wang Y, Gao H. Facilitating creep-resistant Al alloy design through a physics-aware integrated machine learning pipeline. Materials Today Communications 2026, 51: 114676. DOI: 10.1016/j.mtcomm.2026.114676.Peer-Reviewed Original ResearchMachine learning pipelineVolume fractionThreshold stressAl alloyLearning pipelineCreep-induced failureDislocation-climb mechanismFeature dimensionality reductionHot-end componentsCast Al alloyLong-term dimensional stabilityHeat-resistant Al alloysCreep threshold stressDownsized enginesKinetic stabilization effectsCylinder headHeterogeneous modalitiesLightweight alloysData miningDimensionality reductionAlloy designBayesian optimizationDimensional stabilityML surrogateModeling burdenAn engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery
Xu M, Liu H, Wang J, Vieira A, Zhou X, Liu N, Liang J, Du A, Chen X, Xing R, Yang Y, Gonzalez-Perez M, Kumar V, Wang D. An engineered UGA suppressor tRNA gene for disease-agnostic AAV delivery. Nature Biotechnology 2026, 1-10. PMID: 41555020, DOI: 10.1038/s41587-025-02982-5.Peer-Reviewed Original ResearchRecombinant adeno-associated virusRAAV vector productionAdeno-associated virusPathogenic nonsense variantIn vivo deliveryC-to-T transitionLysosomal storage disorderAAV deliveryMouse modelPotential therapeutic scopeNonsense variantNonsense mutationTherapeutic approachesTherapeutic effectGenes in vivoNormal levelsSuppressor tRNA geneUGA stop codonStorage disorderSuppressor transfer RNATranscriptional regulatory elementsCGA arginine codonTherapeutic scopeTRNA genesTransfer RNAA unifying geometric framework for computational representation of stereoisomers based on mixed product
Shi R, Zhang C, Yu G, Huo X, Yang Y. A unifying geometric framework for computational representation of stereoisomers based on mixed product. Cell Reports Physical Science 2026, 7: 103065. DOI: 10.1016/j.xcrp.2025.103065.Peer-Reviewed Original ResearchStereogenic elementsCahn-Ingold-Prelog rulesCahn-Ingold-PrelogAxial chiralityComplex chiralityHelical chiralityMolecular symmetryMolecular chiralityDegree of chiralityProduct representationChiralityMachine learning modelsDrug discoveryComputational representationGeometric solutionQuantification capabilitiesSpectrum predictionLearning modelsBenchmarking resultsMixing productsQualitative rulesComputational toolsGeometric frameworkStereoisomersQuantitative descriptors
2025
Analytic polarizability and vibrational Raman spectra from constrained nuclear-electronic orbital density functional theory
Chen H, Zhang Y, Wang Y, Xuan K, Chen Z, Yang Y. Analytic polarizability and vibrational Raman spectra from constrained nuclear-electronic orbital density functional theory. The Journal Of Chemical Physics 2025, 163: 244111. PMID: 41459953, DOI: 10.1063/5.0301302.Peer-Reviewed Original ResearchVibrational Raman spectraDensity functional theoryRaman spectraCNEO-DFTFunctional theoryNuclear-electronic orbital density functional theoryHydrogen motionNuclear quantum effectsNormal-mode coordinatesStatic polarizabilitiesVibrational frequenciesMolecular dynamicsFormic acidNuclear-electronicRaman intensityConventional DFTPolarizabilitySpectraQuantum effectsDFTCNEOEfficient approachPolarizabilitiesAnharmonicityHydrogenAlign then clip: Refining graph for face clustering
Tu Y, Cao G, Shen J, Huang Y, Wang M, Liu W, Qian C, Yang Y. Align then clip: Refining graph for face clustering. Neural Networks 2025, 197: 108474. PMID: 41435730, DOI: 10.1016/j.neunet.2025.108474.Peer-Reviewed Original ResearchCross-domain generalizationFace clusteringFace recognition datasetsReal-world scenariosReal world applicationsAnnotation costNode representationsRecognition datasetsRefinement graphPruning strategyFacial imagesGraph constructionHyperparameter kGraph structureMethod's scalabilityClean graphsKNN-basedFalse-positive edgesGNNScalabilityGraphInput graphRobustnessNoiseApproach modelStructural and catalytic diversity of coronavirus proofreading exoribonuclease
Li Y, Cao X, Recker L, Yang Y, Liu C. Structural and catalytic diversity of coronavirus proofreading exoribonuclease. Nature Communications 2025 PMID: 41361186, DOI: 10.1038/s41467-025-67140-6.Peer-Reviewed Original ResearchCryo-EM structureProofreading exoribonucleaseRNA substratesCatalytic diversityGenomic mutation rateBiochemical analysisImmune evasionViral life cycleExon structureMERS-CoVAnalysis of exonsRNA proofreadingSarbecovirus subgenusGenome fidelityMutation rateSubgenusResistance to antiviral drugsExonEfficient excisionMolecular basisExoribonucleaseMiddle East respiratory syndrome coronavirusSARS-CoV-2Viral fitnessRespiratory syndrome coronavirusChiralCat: Molecular chirality classification with enhanced spatial representation using learnable queries
Peng Y, Yu G, Shi R, Chen L, Wang X, Du W, Huo X, Yang Y. ChiralCat: Molecular chirality classification with enhanced spatial representation using learnable queries. Artificial Intelligence Chemistry 2025, 3: 100091. DOI: 10.1016/j.aichem.2025.100091.Peer-Reviewed Original ResearchLearnable queriesRepresentation learning modelMulti-modal classifierMachine learning methodsLanguage modelRepresentation modelModel trainingLearning methodsAsymmetric catalysisMolecule datasetLearning modelsMolecular representationsProtein-drug bindingSpatial featuresChiral typeMolecular chiralityChiral studiesQueryExperimental resultsPrediction approachChiralityDatasetSuperior capabilitiesClassificationRepresentation
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