Xin Tian, MD
Associate Research Scientist in Medicine (Nephrology)Cards
About
Research
Publications
2025
Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease
Wei Z, Gu J, Tian X, Zhang C, Zhao H, Somlo S. Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2025 DOI: 10.1681/asn.0000000980.Peer-Reviewed Original ResearchPolycystin-1Autosomal dominant polycystic kidney diseaseRNA-seqAllelic seriesTranscription factorsPolycystin-2Polycystic kidney diseaseIn vivo genetic interactionChromatin accessibility assaysDominant polycystic kidney diseaseChromatin accessibility analysesPolycystin-1 expressionRibosome affinity purificationPolycystin signalingATAC-seqFatty acid metabolismGenetic interactionsCiliary localizationGene familyLive cell imagingEpithelial cell metabolismAffinity purificationGenetic relationshipsEarly effectorsProtein expression studiesNovel Endogenous Pkd1 Reexpression Allele and Effects of Mosaic Reexpression of Pkd1 in ADPKD
Cordido A, Dong K, Cai Y, Tian X, Wei Z, Rehman M, Roy K, Somlo S. Novel Endogenous Pkd1 Reexpression Allele and Effects of Mosaic Reexpression of Pkd1 in ADPKD. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025kkmvzqz1. DOI: 10.1681/asn.2025kkmvzqz1.Peer-Reviewed Original ResearchAnks3 Mediates Cilia-Dependent Polycystin Signaling and Is Essential for Adult Kidney Homeostasis
Wei Z, Rehman M, Dong K, Roy K, Cordido A, Cai Y, Tian X, Somlo S. Anks3 Mediates Cilia-Dependent Polycystin Signaling and Is Essential for Adult Kidney Homeostasis. Journal Of The American Society Of Nephrology 2025, 36: 10.1681/asn.2025jd14p7gt. DOI: 10.1681/asn.2025jd14p7gt.Peer-Reviewed Original Research
2024
Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Wei Z, Tian X, Rehman M, Dong K, Cai Y, Cordido A, Somlo S. Glis3 Is a Modifier of Cyst Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD). Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024x2zerq4t. DOI: 10.1681/asn.2024x2zerq4t.Peer-Reviewed Original ResearchFunctional Studies of Polycystin-1 Using a Novel Pkd1-HaloTag Mouse
Cordido A, Dong K, Cai Y, Tian X, Wei Z, Rehman M, Somlo S. Functional Studies of Polycystin-1 Using a Novel Pkd1-HaloTag Mouse. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024kjqymtyt. DOI: 10.1681/asn.2024kjqymtyt.Peer-Reviewed Original ResearchChemical Modulation of the Ire1α-Xbp1 Pathway Reduces Cyst Size in ADPKD Mouse and Human Three-Dimensional Spheroids
Hasan F, Bhardwaj R, Rehman M, Cai Y, Dong K, Cordido A, Pioppini C, Yilmaz D, Tian X, Somlo S, Krappitz M, Fedeles S. Chemical Modulation of the Ire1α-Xbp1 Pathway Reduces Cyst Size in ADPKD Mouse and Human Three-Dimensional Spheroids. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024x8qpvhm3. DOI: 10.1681/asn.2024x8qpvhm3.Peer-Reviewed Original ResearchGlis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease
Zhang C, Rehman M, Tian X, Pei S, Gu J, Bell T, Dong K, Tham M, Cai Y, Wei Z, Behrens F, Jetten A, Zhao H, Lek M, Somlo S. Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. Nature Communications 2024, 15: 3698. PMID: 38693102, PMCID: PMC11063051, DOI: 10.1038/s41467-024-48025-6.Peer-Reviewed Original ResearchConceptsMouse models of autosomal dominant polycystic kidney diseaseModel of autosomal dominant polycystic kidney diseasePolycystin signalingAutosomal dominant polycystic kidney diseasePolycystin-1Polycystic kidney diseaseTreat autosomal dominant polycystic kidney diseaseGlis2Primary ciliaKidney tubule cellsSignaling pathwayMouse modelDominant polycystic kidney diseasePotential therapeutic targetTranslatomeAntisense oligonucleotidesKidney diseasePolycystinMouse kidneyFunctional effectorsCyst formationTherapeutic targetInactivationFunctional targetPharmacological targets
2023
Dephosphorylation Facilitates Trafficking of Mutant Polycystin-2 to Cilia
Cai Y, Dong K, Spitzer M, Geiges L, Tian X, Krappitz M, Diggs L, Wei Z, Cordido A, Pei S, Fedeles S, Somlo S. Dephosphorylation Facilitates Trafficking of Mutant Polycystin-2 to Cilia. Journal Of The American Society Of Nephrology 2023, 34: 560-560. DOI: 10.1681/asn.20233411s1560b.Peer-Reviewed Original ResearchDnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice
Roy S, Li Z, Guo Z, Long K, Rehrl S, Tian X, Dong K, Besse W. Dnajb11-Kidney Disease Develops from Reduced Polycystin-1 Dosage but not Unfolded Protein Response in Mice. Journal Of The American Society Of Nephrology 2023, 34: 1521-1534. PMID: 37332102, PMCID: PMC10482070, DOI: 10.1681/asn.0000000000000164.Peer-Reviewed Original ResearchConceptsUnfolded protein responseAutosomal dominant tubulointerstitial kidney diseaseAutosomal dominant polycystic kidney diseasePolycystin-1Autosomal-dominant polycystic kidney diseaseProtein responseTubulointerstitial kidney diseaseKidney diseaseRenal failureRenal failure in adulthoodPolycystic kidney diseaseUnfolded protein response activationFull-length proteinProteins polycystin-1C-terminal fragmentCystic kidneysSite of maturationCystic kidney dysplasiaKidney disease pathogenesisHeterozygous inactivating mutationsHsp40 cochaperonesEndoplasmic reticulumMouse model studiesConditional allelesDNAJB11
2022
Pkd2 Re-Expression Can Reverse Liver Cysts and Improve GFR in Mouse Models of Autosomal Dominant Polycystic Kidney Disease
Dong K, Tham M, Cordido A, Cai Y, Pei S, Bhardwaj R, Wei Z, Rehman M, Roy K, Tian X, Somlo S. Pkd2 Re-Expression Can Reverse Liver Cysts and Improve GFR in Mouse Models of Autosomal Dominant Polycystic Kidney Disease. Journal Of The American Society Of Nephrology 2022, 33: 418-418. DOI: 10.1681/asn.20223311s1418c.Peer-Reviewed Original Research
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