Xiaoting Shi
About
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Biography
Xiaoting Shi is a doctoral student in the Department of Environmental Health Sciences. Her research and training focus on synthesizing evidence, conducting meta-research (i.e., research on research) projects, and applying causal inference methods in environmental epidemiology. In particular, she has developed an interest in and currently works on various research projects that: 1) synthesize and assess the evidence from literature, including systematic reviews, and umbrella reviews. 2) evaluate current publication practices, including evaluation of preprints, investigation of retracted publications, and estimation of publication fees. 3) conduct research on regulatory science, including evaluating regulatory policies by the US FDA and developing tools to facilitate real-world data to inform regulatory decision-making. Specifically, Xiaoting is part of the 2021-2022 CERSI Scholars Program to support regulatory science research that addresses the mission of the FDA. 4) utilize causal inference methods, including quantitative bias analysis and Mendelian randomization methods.
As a graduate teaching fellow at Yale, she has taught multiple courses and led various online workshops on research skills training for master students. She is also passionate about gaining more teaching experience in the future. Before coming to Yale, Xiaoting received her Bachelor's Degree in Preventive Medicine with a minor in Statistics in 2019.
Education & Training
- BMedSci
- Shanghai Jiao Tong University, Preventive Medicine (2019)
- BS
- East China Normal University, Statistics (Minor) (2019)
Research
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Overview
Medical Research Interests
Public Health Interests
ORCID
0000-0002-5256-0646
Research at a Glance
Yale Co-Authors
Research Interests
Joseph Ross, MD, MHS
Kate Nyhan, MLS
Tormod Rogne, MD, PhD
Zeyan Liew, PhD, MPH
Harlan Krumholz, MD, SM
Joshua J. Skydel, MD
Mendelian Randomization Analysis
Lymphoma, Non-Hodgkin
Publications
2024
Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study
Shi X, Wallach J, Ma X, Rogne T. Autoimmune Diseases and Risk of Non‐Hodgkin Lymphoma: A Mendelian Randomisation Study. Cancer Medicine 2024, 13: e70327. PMID: 39506244, PMCID: PMC11540836, DOI: 10.1002/cam4.70327.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsRisk of non-Hodgkin lymphomaNon-Hodgkin's lymphomaAutoimmune diseasesMendelian randomisationType 1 diabetesAssociated with risk of non-Hodgkin lymphomaWeak instrument biasNon-Hodgkin lymphoma subtypesTwo-sample MRNon-Hodgkin lymphoma riskRisk factorsSusceptibility to type 1 diabetesMendelian randomisation studiesCohorts of European ancestryAssociated with riskNo significant associationPotential pleiotropyPotential risk factorsUK BiobankFinnGen studyNon-HodgkinHaematological malignanciesRandomised studyEuropean ancestrySignificant associationQuantitative bias analysis methods for summary-level epidemiologic data in the peer-reviewed literature: a systematic review
Shi X, Liu Z, Zhang M, Hua W, Li J, Lee J, Dharmarajan S, Nyhan K, Naimi A, Lash T, Jeffery M, Ross J, Liew Z, Wallach J. Quantitative bias analysis methods for summary-level epidemiologic data in the peer-reviewed literature: a systematic review. Journal Of Clinical Epidemiology 2024, 175: 111507. PMID: 39197688, PMCID: PMC12135099, DOI: 10.1016/j.jclinepi.2024.111507.Peer-Reviewed Original ResearchCitationsAltmetricConceptsQuantitative bias analysis methodsQuantitative bias analysisPeer-reviewed literatureSystematic reviewEpidemiological dataObservational studyOpen Science FrameworkEnglish-language articlesWeb of ScienceMisclassification biasImpact of biasScience FrameworkStudy designEffect estimatesMeta-analysesPre-registeredStudy protocolBias analysisSelection biasLevel dataFuture investigationsMultiple biasesConfoundingReviewMEDLINEMediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes
Rogne T, Gill D, Liew Z, Shi X, Stensrud V, Nilsen T, Burgess S. Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes. JAMA Network Open 2024, 7: e2351166. PMID: 38206626, PMCID: PMC10784860, DOI: 10.1001/jamanetworkopen.2023.51166.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsBirth WeightCholesterolCohort StudiesDiabetes Mellitus, Type 2Educational StatusFemaleGenome-Wide Association StudyHumansHyperemesis GravidarumInfant, NewbornLipoproteins, HDLMediation AnalysisMendelian Randomization AnalysisPre-EclampsiaPregnancyPregnancy OutcomePregnancy, EctopicPremature BirthConceptsCardiometabolic risk factorsBody mass indexOffspring birth weightEducational attainmentMendelian randomizationHigh-density lipoprotein cholesterol levelsSystolic blood pressureInverse variance-weighted methodModifiable cardiometabolic risk factorsPregnancy outcomesCohort studyLipoprotein cholesterol levelsMR-Egger regressionMass indexUnivariable MR analysisEffects of educational attainmentAssociated with increased risk of adverse pregnancy outcomesPublic health interventionsMaternal education levelLower educational attainmentRisk factorsRisk of adverse pregnancy outcomesGenome-wide association studiesAssociated with increased riskBirth weight
2022
Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-reviewed Journal Articles
Janda G, Khetpal V, Shi X, Ross J, Wallach J. Comparison of Clinical Study Results Reported in medRxiv Preprints vs Peer-reviewed Journal Articles. JAMA Network Open 2022, 5: e2245847. PMID: 36484989, PMCID: PMC9856222, DOI: 10.1001/jamanetworkopen.2022.45847.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrimary end pointPrimary end point resultsPeer-reviewed journalsClinical studiesEnd pointClinical trialsObservational studyStudy characteristicsEnd point resultsClinical study resultsMost clinical studiesCross-sectional studyHealth-related outcomesSample sizeMAIN OUTCOMEPeer-reviewed publicationsMedRxivEffect estimatesStudy interpretationDiscordant pairsCOVID-19TrialsCharacterization and corroboration of safety signals identified from the US Food and Drug Administration Adverse Event Reporting System, 2008-19: cross sectional study
Dhodapkar MM, Shi X, Ramachandran R, Chen EM, Wallach JD, Ross JS. Characterization and corroboration of safety signals identified from the US Food and Drug Administration Adverse Event Reporting System, 2008-19: cross sectional study. The BMJ 2022, 379: e071752. PMID: 36198428, PMCID: PMC9533298, DOI: 10.1136/bmj-2022-071752.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPotential safety signalsSafety signalsSectional studyUS FoodDrug Administration Adverse Event Reporting SystemLiterature searchAdverse Event Reporting SystemSentinel InitiativeDrug Safety CommunicationsEvent Reporting SystemDrug safety signalsAdverse eventsCase seriesCase reportRegulatory actionDrug labelingSignificant associationFDA regulatory actionsComprehensive safety evaluationFAERSFDACharacteristics of Retracted Research Articles About COVID-19 vs Other Topics
Shi X, Abritis A, Patel RP, Grewal M, Oransky I, Ross JS, Wallach JD. Characteristics of Retracted Research Articles About COVID-19 vs Other Topics. JAMA Network Open 2022, 5: e2234585. PMID: 36194415, PMCID: PMC9533180, DOI: 10.1001/jamanetworkopen.2022.34585.Peer-Reviewed Original ResearchCitationsAltmetricEnvironmental risk factors for non-Hodgkin's lymphoma: umbrella review and comparison of meta-analyses of summary and individual participant data
Shi X, Zhuo H, Du Y, Nyhan K, Ioannidis J, Wallach J. Environmental risk factors for non-Hodgkin's lymphoma: umbrella review and comparison of meta-analyses of summary and individual participant data. BMJ Medicine 2022, 1: e000184. PMID: 36936582, PMCID: PMC9978687, DOI: 10.1136/bmjmed-2022-000184.Peer-Reviewed Original ResearchCitationsAltmetricConceptsIndividual participant dataEnvironmental risk factorsHodgkin's lymphomaRisk factorsUmbrella reviewSummary-level dataParticipant dataInternational Lymphoma Epidemiology ConsortiumIndividual participant-level dataAMSTAR-2 toolRelated risk factorsConfidence intervalsParticipant-level dataRandom-effects modelUnique environmental risk factorsSummary effect sizeCoeliac diseasePotential confoundersCochrane LibraryMethodological qualityEligibility criteriaLymphomaRegistration numberEpidemiology ConsortiumEvidence synthesis
2021
Assessment of Concordance and Discordance Among Clinical Studies Posted as Preprints and Subsequently Published in High-Impact Journals
Shi X, Ross JS, Amancharla N, Niforatos JD, Krumholz HM, Wallach JD. Assessment of Concordance and Discordance Among Clinical Studies Posted as Preprints and Subsequently Published in High-Impact Journals. JAMA Network Open 2021, 4: e212110. PMID: 33734411, PMCID: PMC7974637, DOI: 10.1001/jamanetworkopen.2021.2110.Peer-Reviewed Original ResearchCitationsAltmetricPublishing at any cost: a cross-sectional study of the amount that medical researchers spend on open access publishing each year
Ellingson MK, Shi X, Skydel JJ, Nyhan K, Lehman R, Ross JS, Wallach JD. Publishing at any cost: a cross-sectional study of the amount that medical researchers spend on open access publishing each year. BMJ Open 2021, 11: e047107. PMID: 33526505, PMCID: PMC7852964, DOI: 10.1136/bmjopen-2020-047107.Peer-Reviewed Original ResearchCitationsAltmetric
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