Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsTony Tiganis
Professor AdjunctAbout
Research
Publications
2026
A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging
Xirouchaki C, García-Domínguez E, Coughlan E, McGrath M, Giri S, Liang S, Wiede F, Bigot A, Sadoshima J, Gomez-Cabrera M, Philp A, Moberg M, Apró W, Roman W, Mitchell C, Tiganis T. A decline in skeletal muscle NOX4 abrogates exercise-induced adaptive homeostasis and exacerbates biological aging. Science Advances 2026, 12: eadz1953. PMID: 42268956, PMCID: PMC13251858, DOI: 10.1126/sciadv.adz1953.Peer-Reviewed Original ResearchConceptsPhysical inactivityNADPH oxidase 4Adaptive homeostasisAdvanced liver diseaseNox4-deficient miceMuscle functionSkeletal muscleHealthy agingChow-fed miceNuclear factor erythroid 2-related factor 2Factor erythroid 2-related factor 2Enzyme NADPH oxidase 4Erythroid 2-related factor 2Whole-body insulin resistanceAdaptive homeostatic responsesSystemic inflammationInactivityExerciseAged miceNOX4 levelsViral approachesLiver diseaseBiological ageFeatures of agingInsulin resistance
2025
Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer
Ooms L, Ferguson D, Rodgers S, Sukhija K, Jones E, Csolle M, Yip H, Daly R, Tiganis T, McLean C, Papa A, Mitchell C. Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer. Communications Biology 2025, 9: 96. PMID: 41408399, PMCID: PMC12827249, DOI: 10.1038/s42003-025-09364-2.Peer-Reviewed Original ResearchPI phosphatasesBreast cancerExperimental models of breast cancerInositol polyphosphate 5-phosphataseModel of breast cancerAkt signalingMammary epithelial cell transformationPhosphoinositide phosphatase PTENPI3K/Akt signalingBreast cancer cell linesExperimental modelBreast cancer progressionCell proliferationEpithelial cell transformationHuman breast cancerNon-redundant rolePhosphoinositide 3-kinaseTumor suppressor PTENPI3K) signalingLipid productionCancer cell linesPIK3CA mutationsPathway in vivoMutant PIK3CAPhosphatase PTENTargeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models
Du X, Goh P, Ma C, Coughlan E, Greatorex S, Porter L, Russ B, Cummins K, Sek K, Slaney C, Scott A, Oliaro J, Neeson P, Risbridger G, Taylor R, Trapani J, Turner S, Darcy P, Wiede F, Tiganis T. Targeting PTPN2 enhances human CAR T cell efficacy and the development of long-term memory in mouse xenograft models. Science Translational Medicine 2025, 17: eadk0627. PMID: 41160667, DOI: 10.1126/scitranslmed.adk0627.Peer-Reviewed Original ResearchConceptsCD8+ CAR T cellsChimeric antigen receptor T cellsProtein tyrosine phosphatase N2CAR-T cellsChimeric antigen receptorHuman CAR-T cellsStem cell memoryT cellsIntratumoral accumulationSolid tumorsChimeric antigen receptor T-cell functionCAR-T cells in vitroCAR T cell efficacyT cells in vitroAntigen-induced expansionT cell efficacyGrowth of human tumorsT cell toleranceT cell functionPatient-derived xenograftsTumor-bearing miceHostile tumor microenvironmentCellular indicesT cell receptorAdministration of inhibitorsMechanisms, functions and therapeutic targeting of protein tyrosine phosphatases
Tiganis T, Tonks N. Mechanisms, functions and therapeutic targeting of protein tyrosine phosphatases. Nature Reviews Molecular Cell Biology 2025, 27: 129-152. PMID: 41028199, DOI: 10.1038/s41580-025-00882-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProtein tyrosine phosphataseCell signalingTyrosine phosphataseRegulation of cell signalingHuman diseasesProtein tyrosine kinasesTherapeutic targetTyrosine kinaseProteinUnique functionsDrug development opportunitiesClinical trialsClinical translationComplex rolePhosphataseSignalKinaseDiseaseEnzymeHuman healthRegulationPhysiologyA consensus guide to preclinical indirect calorimetry experiments
Banks A, Allison D, Alquier T, Ansarullah, Austad S, Auwerx J, Ayala J, Baur J, Carobbio S, Churchill G, Dall M, de Cabo R, Donato J, Dragano N, Elias C, Ferrante A, Finck B, Galgani J, Gerhart-Hines Z, Goodyear L, Grobe J, Gupta R, Habegger K, Hartig S, Hevener A, Heymsfield S, Holman C, de Angelis M, James D, Kazak L, Kim J, Klingenspor M, Kong X, Kooijman S, Lantier L, Lloyd K, Lo J, Lodhi I, MacLean P, McGuinness O, Medina-Gómez G, Mirmira R, Morrison C, Morton G, Müller T, Ogawa Y, Pajuelo-Reguera D, Potthoff M, Qi N, Reitman M, Rensen P, Rozman J, Rutkowsky J, Sakamoto K, Scherer P, Schwartz G, Sedlacek R, Selloum M, Shaikh S, Chen S, Shulman G, Škop V, Soukas A, Speakman J, Spiegelman B, Steinberg G, Svensson K, Thyfault J, Tiganis T, Titchenell P, Turner N, Velloso L, Vidal-Puig A, Ward C, Williams A, Wolfrum C, Xu A, Xu Y, Zierath J. A consensus guide to preclinical indirect calorimetry experiments. Nature Metabolism 2025, 7: 1765-1780. PMID: 40993210, PMCID: PMC12974399, DOI: 10.1038/s42255-025-01360-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProtein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics
Bennett A, Tiganis T. Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics. Annual Review Of Physiology 2025, 87: 301-324. PMID: 39531392, DOI: 10.1146/annurev-physiol-022724-105540.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsProtein tyrosine phosphataseFunction of protein tyrosine phosphatasesActions of protein tyrosine kinasesTyrosine phosphorylation-dependent signalingTyrosine phosphataseType 2 diabetesPhosphorylation-dependent signalingPathophysiology of metabolic diseasesPrevalence of chronic metabolic disordersProtein tyrosine kinasesMetabolic disordersChronic metabolic disorderMetabolic homeostasisTyrosine kinaseIncreased prevalencePharmaceutical strategiesMetabolic diseasesGlucose metabolismMetabolismProteinBody weightObesityPhosphataseComplex interplayDisorders
2024
miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression
Fernández-Tussy P, Cardelo M, Zhang H, Sun J, Price N, Boutagy N, Goedeke L, Cadena-Sandoval M, Xirouchaki C, Brown W, Yang X, Pastor-Rojo O, Haeusler R, Bennett A, Tiganis T, Suárez Y, Fernández-Hernando C. miR-33 deletion in hepatocytes attenuates NAFLD-NASH-HCC progression. JCI Insight 2024, 9: e168476. PMID: 39190492, PMCID: PMC11466198, DOI: 10.1172/jci.insight.168476.Peer-Reviewed Original ResearchMiR-33Regulation of biological processesMitochondrial fatty acid oxidationRegulation of lipid metabolismNon-alcoholic fatty liver diseaseDevelopment of effective therapeuticsFatty acid oxidationLipid synthesisProgression of non-alcoholic fatty liver diseaseMitochondrial functionTarget genesBiological processesComplex diseasesNon-alcoholic steatohepatitisLipid accumulationDeletionDevelopment of non-alcoholic fatty liver diseasePathway activationLipid metabolismProgress to non-alcoholic steatohepatitisAcid oxidationHCC progressionEffective therapeuticsTherapeutic targetHepatocellular carcinoma
2023
Mitochondrial- and NOX4-dependent antioxidant defence mitigates progression to non-alcoholic steatohepatitis in obesity
Greatorex S, Kaur S, Xirouchaki C, Goh P, Wiede F, Genders A, Tran M, Jia Y, Raajendiran A, Brown W, McLean C, Sadoshima J, Watt M, Tiganis T. Mitochondrial- and NOX4-dependent antioxidant defence mitigates progression to non-alcoholic steatohepatitis in obesity. Journal Of Clinical Investigation 2023, 134: e162533. PMID: 38060313, PMCID: PMC10849767, DOI: 10.1172/jci162533.Peer-Reviewed Original Research