Terrell D Holloway, MD
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Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. Greater stress and trauma mediate race-related differences in epigenetic age between Black and White young adults in a community sample. Neurobiology Of Stress 2023, 26: 100557. PMID: 37501940, PMCID: PMC10369475, DOI: 10.1016/j.ynstr.2023.100557.Peer-Reviewed Original ResearchTraumatic eventsGrimAge accelerationMore traumatic eventsWhite participantsExploratory mediation analysisMajor life eventsImpact of stressAssaultive traumaPsychological dataCross-sectional sampleCommunity sampleLife eventsMediation analysisLifetime stressRace-related differencesChronic stressorsCumulative stressorsYoung adultsCumulative stressChronic illnessYoung adult populationStressorsGreater stressHealthy adultsParticipantsWitnessing Modern America: Violence and Racial Trauma
Williams JC, Holloway TD, Ross DA. Witnessing Modern America: Violence and Racial Trauma. Biological Psychiatry 2019, 86: e41-e42. PMID: 31668222, PMCID: PMC7220206, DOI: 10.1016/j.biopsych.2019.09.025.Peer-Reviewed Original ResearchEpigenetic Mechanisms of Serotonin Signaling
Holloway T, González-Maeso J. Epigenetic Mechanisms of Serotonin Signaling. ACS Chemical Neuroscience 2015, 6: 1099-1109. PMID: 25734378, PMCID: PMC4838281, DOI: 10.1021/acschemneuro.5b00033.Peer-Reviewed Original ResearchConceptsEpigenetic mechanismsHeritable epigenetic modificationsNumerous physiological responsesSignal transduction mechanismsReceptor-dependent signalingEpigenetic marksHistone modificationsGene functionEpigenetic modificationsDNA methylationCellular phenotypesGene expressionTransduction mechanismsPhysiological responsesFundamental roleDiverse setComplex interactionsCentral nervous systemRecent advancesFundamental questionsIntense researchMethylationNervous systemSignalingMechanismPrenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System
Holloway T, Moreno JL, Umali A, Rayannavar V, Hodes GE, Russo SJ, González-Maeso J. Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System. Journal Of Neuroscience 2013, 33: 1088-1098. PMID: 23325246, PMCID: PMC3711555, DOI: 10.1523/jneurosci.2331-12.2013.Peer-Reviewed Original ResearchConceptsMetabotropic glutamate 2 receptorPrenatal stressSevere adverse life eventsSchizophrenia-like alterationsMaternal immune systemHead-twitch responsePrenatal immune activationAntipsychotic-like effectsAntipsychotic drug developmentMGlu2/3 agonist LY379268Risk of schizophreniaAdverse life eventsCross-fostering studyEarly neurodevelopmental originHallucinogenic 5Serotonin 2AAgonist DOIImmune activationAgonist LY379268Pathophysiological hypothesesFrontal cortexPsychiatric disordersAdult offspringSerotonin 5Behavioral alterationsHDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks J, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nature Neuroscience 2012, 15: 1245-1254. PMID: 22864611, PMCID: PMC3431440, DOI: 10.1038/nn.3181.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAnimalsAntipsychotic AgentsBenzamidesChromatin ImmunoprecipitationClozapineDNA MethylationGenetic VectorsHEK293 CellsHerpesvirus 2, HumanHistone Deacetylase 2HistonesHumansHydroxamic AcidsImmunohistochemistryMiceMice, KnockoutPatch-Clamp TechniquesPlasmidsPrefrontal CortexPromoter Regions, GeneticPyridinesReal-Time Polymerase Chain ReactionReceptor, Serotonin, 5-HT2AReceptors, Metabotropic GlutamateReflex, StartleSchizophrenic PsychologyVorinostat
2022
P75. Stress and Trauma Mediate Some, But Not All, Differences in GrimAge Acceleration Between Black and White Participants in Observed Cohort Study
Holloway T, Harvanek Z, Xu K, Gordon D, Sinha R. P75. Stress and Trauma Mediate Some, But Not All, Differences in GrimAge Acceleration Between Black and White Participants in Observed Cohort Study. Biological Psychiatry 2022, 91: s117. DOI: 10.1016/j.biopsych.2022.02.309.Peer-Reviewed Original Research
2021
50.11 Reported Discrimination Predicts Biomarkers of Adverse Medical Outcomes Using Machine Learning Methodology
Holloway T, MacLeod J, Kamal S, Gordon D. 50.11 Reported Discrimination Predicts Biomarkers of Adverse Medical Outcomes Using Machine Learning Methodology. Journal Of The American Academy Of Child & Adolescent Psychiatry 2021, 60: s253. DOI: 10.1016/j.jaac.2021.09.392.Peer-Reviewed Original ResearchRacial and Ethnic Differences in Psychiatry Resident Prescribing: a Quality Improvement Education Intervention to Address Health Equity
Cerdeña I, Holloway T, Cerdeña JP, Wing A, Wasser T, Fortunati F, Rohrbaugh R, Li L. Racial and Ethnic Differences in Psychiatry Resident Prescribing: a Quality Improvement Education Intervention to Address Health Equity. Academic Psychiatry 2021, 45: 13-22. PMID: 33495966, PMCID: PMC9942699, DOI: 10.1007/s40596-021-01397-z.Peer-Reviewed Original ResearchConceptsWhite patientsRace/ethnicityPrescriber profilesLatinx patientsEthnic differencesUnique patient encountersPrescription of antipsychoticsElectronic medical recordsAntidepressant prescriptionsAntipsychotic prescribingAntidepressant prescribingHigher diagnosisPrimary diagnosisMedical recordsDepression diagnosisMedication ordersClinical careLower oddsPatientsPsychotic disordersPatient encountersHealth disparitiesPrescribingConclusionsOur findingsEducation intervention
2018
HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice
de la Fuente Revenga M, Ibi D, Saunders J, Cuddy T, Ijaz M, Toneatti R, Kurita M, Holloway T, Shen L, Seto J, Dozmorov M, González-Maeso J. HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice. Neuroscience 2018, 388: 102-117. PMID: 30025863, PMCID: PMC6129430, DOI: 10.1016/j.neuroscience.2018.07.010.Peer-Reviewed Original ResearchConceptsHDAC inhibitor SAHAChronic treatmentControl miceFrontal cortexSchizophrenia patientsSynaptic plasticityChronic antipsychotic drug exposureHistone deacetylase 2 (HDAC2) expressionGlutamatergic pyramidal neuronsChronic antipsychotic treatmentAntipsychotic drug exposureAntipsychotic drug actionNew therapeutic approachesConditional knockout micePlasticity-related genesAntipsychotic treatmentPyramidal neuronsDrug exposureAntipsychotic drugsFunctional synapsesHDAC2 functionTherapeutic approachesKnockout micePresynaptic terminalsSAHA treatment
2016
HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
Holloway T, Moreno J, González-Maeso J. HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice. Journal Of Visualized Experiments 2016 DOI: 10.3791/53717-v.Peer-Reviewed Original Research
Academic Achievements & Community Involvement
News
News
- July 24, 2023Source: Neurobiology of Stress
Greater Stress and Trauma Mediate Race-Related Differences in Epigenetic Age Between Black and White Young Adults in a Community Sample
- July 19, 2023
2023 Residents, Fellows Honored at Annual Commencement Ceremonies
- May 12, 2022
Lustman, Detre Award Recipients Announced
- April 22, 2022
Holloway, Patterson, Okani, and Uradu Named Chief Residents for 2022-23