Siyuan Cheng

2025

• Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer.

  Jiang Y, Cheng S, Li L, Fraidenburg M, Kim IY, Deng S, Mu P. Notch as a Driver of Lineage Plasticity and Therapeutic Target in Enzalutamide-Resistant Prostate Cancer. BioRxiv 2025 PMID: 40501767, DOI: 10.1101/2025.05.26.656166.

  Peer-Reviewed Original Research

• Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity.

  Jiang Y, Cheng S, Kim IY, Deng S, Mu P. Pan-cancer Analysis Identified Ectopic RUNX1T1 Associated with Lineage Plasticity. BioRxiv 2025 PMID: 40488132, DOI: 10.1101/2025.04.18.649575.

  Peer-Reviewed Original Research

• Androgen Deprivation-Induced TET2 Activation Fuels Prostate Cancer Progression via Epigenetic Priming and Slow-Cycling Cancer Cells.

  Li L, Cheng S, Xu Y, Deng S, Mu P, Yu X. Androgen Deprivation-Induced TET2 Activation Fuels Prostate Cancer Progression via Epigenetic Priming and Slow-Cycling Cancer Cells. BioRxiv 2025 PMID: 40196510, DOI: 10.1101/2025.03.26.645495.

  Peer-Reviewed Original Research