Sheryl Roberts, PhD
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Teaching & Mentoring
Contact/Administration
About
Teaching & Mentoring
Contact/Administration
Contact Info
Radiology & Biomedical Imaging
Tompkin's East 2, PO Box 208042
New Haven, Connecticut 06520
United States
Social Media
Titles
Assistant Professor
Appointments
Willing and Available to Mentor
- Clinical Fellows
- Postdoctoral Researchers
- Residents
- Students
Mentoring
- 7 Mentored Students and Faculty
- 1 Mentee Publication
Contact Info
Radiology & Biomedical Imaging
Tompkin's East 2, PO Box 208042
New Haven, Connecticut 06520
United States
Social Media
Titles
Assistant Professor
Appointments
Willing and Available to Mentor
- Clinical Fellows
- Postdoctoral Researchers
- Residents
- Students
Mentoring
- 7 Mentored Students and Faculty
- 1 Mentee Publication
Contact Info
Radiology & Biomedical Imaging
Tompkin's East 2, PO Box 208042
New Haven, Connecticut 06520
United States
Social Media
About
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Titles
Assistant Professor
Appointments
Radiology & Biomedical Imaging
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Postdoctoral Training
- Memorial Sloan Kettering Cancer Center (2022)
- PhD
- Technical University of Munich, Medical Life Science and Technology (2017)
- MSc
- University of St. Andrews, Chemistry with Medicinal Chemistry and Industrial Placement MChem (Hons) (2011)
Research
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Overview
We are building a research program focused on radioligand strategies to define and exploit cancer vulnerabilities.
Medical Research Interests
Chemistry, Pharmaceutical
Public Health Interests
Cancer; Biomarkers
ORCID
0000-0002-2326-9120- View Lab Website
Chemical & Biomedical Imaging Lab
Publications
Featured Publications
High-Affinity Probes for Androgen Receptor Imaging: From Cells and In Silico Modeling to Whole-Body Fluorescent Applications
Ayodeji S, Balytskyi Y, Unaegbu D, Ingman A, Kelly C, Roberts S. High-Affinity Probes for Androgen Receptor Imaging: From Cells and In Silico Modeling to Whole-Body Fluorescent Applications. Journal Of Medicinal Chemistry 2025, 68: 15812-15827. PMID: 40709914, PMCID: PMC12362607, DOI: 10.1021/acs.jmedchem.5c00836.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsCastrate-resistant prostate cancerAndrogen receptorHuman prostate cancer modelAR-positive tumorsProstate cancer modelAR-expressing cellsWild-typeResistance mechanismsMechanism of ARProstate cancerReceptor imagingCancer modelsAR mutantsExcess unlabeled ligandCytoplasmic ARAR inhibitionTreatment decisionsAR inhibitorsNanomolar binding affinityCyclohexane scaffoldImaging toolAndrogenConsistent with experimental resultsHigh-affinity probesConjugated to fluorophoresPARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models
Wilson T, Pirovano G, Xiao G, Samuels Z, Roberts S, Viray T, Guru N, Zanzonico P, Gollub M, Pillarsetty N, Reiner T, Bargonetti J. PARP-Targeted Auger Therapy in p53 Mutant Colon Cancer Xenograft Mouse Models. Molecular Pharmaceutics 2021, 18: 3418-3428. PMID: 34318678, PMCID: PMC8686831, DOI: 10.1021/acs.molpharmaceut.1c00323.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsOff-site toxicityP53-/-P53+/+Xenograft tumorsSystemic administrationColon cancer xenograft mouse modelTreatment of p53 mutant cancersTherapeutic levelsClinical evaluationMouse modelCancer xenograft mouse modelColorectal cancer xenograft tumorsTumor growth delayHuman colorectal cancer cell linesP53 mutant cancersToxicity studiesPARP inhibitor olaparibColorectal cancer cell linesColorectal cancer tumorsXenograft mouse modelSubcutaneous xenograft tumorsBlood chemistry levelsAuger radiationCancer cell DNACancer cell linesSafety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer
Schöder H, De Souza França P, Nakajima R, Burnazi E, Roberts S, Brand C, Grkovski M, Mauguen A, Dunphy M, Ghossein R, Lyashchenko S, Lewis J, O'Donoghue J, Ganly I, Patel S, Lee N, Reiner T. Safety and Feasibility of PARP1/2 Imaging with 18F-PARPi in Patients with Head and Neck Cancer. Clinical Cancer Research 2020, 26: 3110-3116. PMID: 32245901, PMCID: PMC7421489, DOI: 10.1158/1078-0432.ccr-19-3484.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHead and neck cancerFocal uptakeMetastatic lesionsF-FDGNeck cancerLymph nodesFocal uptake of tracerFirst-in-human clinical trialStatic PET/CT scansDynamic PET/CT imagingComplete blood countFeasibility of PETUptake of tracerPET/CT scansOropharyngeal cancerPET/CT imagingPrimary lesionBlood countGenioglossus muscleMinutes postinjectionClinical trialsBlood pressureTracer administrationPatientsEffective doseHigh-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies
Haedicke K, Agemy L, Omar M, Berezhnoi A, Roberts S, Longo-Machado C, Skubal M, Nagar K, Hsu H, Kim K, Reiner T, Coleman J, Ntziachristos V, Scherz A, Grimm J. High-resolution optoacoustic imaging of tissue responses to vascular-targeted therapies. Nature Biomedical Engineering 2020, 4: 286-297. PMID: 32165736, PMCID: PMC7153756, DOI: 10.1038/s41551-020-0527-8.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsBrainCerebral Ventricle NeoplasmsColonic NeoplasmsCraniotomyDiagnostic ImagingDisease Models, AnimalEndothelin-1EpinephrineFemaleHeterograftsImage Processing, Computer-AssistedImaging, Three-DimensionalLasersMiceMice, Inbred BALB CNeovascularization, PathologicOxygenPhotoacoustic TechniquesUltrasonographyUrinary Bladder NeoplasmsVascular NeoplasmsVasoconstrictionConceptsVascular-targeted therapiesRaster-scan optoacoustic mesoscopyVascular-targeted photodynamic therapyIntrinsic optical propertiesMagnetic resonance imagingTumor volumeTumor vesselsTumor vasculatureUltrasound bandwidthImmediate occlusionSubcutaneous xenograftsComputed tomographyTreatment efficacyTherapyPhotodynamic therapyResonance imagingTumorOxygen reperfusionHigh-resolution imagesVasculatureUltrasoundInsufficient spatial resolutionPreclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR
Young R, De Souza França P, Pirovano G, Piotrowski A, Nicklin P, Riedl C, Schwartz J, Bale T, Donabedian P, Kossatz S, Burnazi E, Roberts S, Lyashchenko S, Miller A, Moss N, Fiasconaro M, Zhang Z, Mauguen A, Reiner T, Dunphy M. Preclinical and first-in-human-brain-cancer applications of [18F]poly (ADP-ribose) polymerase inhibitor PET/MR. Neuro-Oncology Advances 2020, 2: vdaa119. PMID: 33392502, PMCID: PMC7758909, DOI: 10.1093/noajnl/vdaa119.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPoly (ADP-ribose) polymerase 1Treatment-related changesBrain cancerPoly (ADP-ribose) polymerase 1 expressionBlood-brain barrier disruptionPreclinical mouse modelsDiagnostic toolBlood-brain barrierCancer cell nucleiRANO-BMResected tissueGlioma modelResponse assessmentTracer uptakePARP inhibitorsBarrier disruptionNeuro-oncologyMouse modelImmunohistochemistry resultsResponse criteriaCancerPET tracersBrain examinationPatientsNoncancerous tissuesSonophore-enhanced nanoemulsions for optoacoustic imaging of cancer
Roberts S, Andreou C, Choi C, Donabedian P, Jayaraman M, Pratt E, Tang J, Pérez-Medina C, de la Cruz M, Mulder W, Grimm J, Kircher M, Reiner T. Sonophore-enhanced nanoemulsions for optoacoustic imaging of cancer. Chemical Science 2018, 9: 5646-5657. PMID: 30061998, PMCID: PMC6049522, DOI: 10.1039/c8sc01706a.Peer-Reviewed Original ResearchCitationsAltmetric[18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model
Pirovano G, Roberts S, Brand C, Donabedian P, Mason C, de Souza P, Higgins G, Reiner T. [18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model. Molecular Imaging And Biology 2018, 21: 705-712. PMID: 30357568, PMCID: PMC6482100, DOI: 10.1007/s11307-018-1288-6.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT-cell-originated protein kinaseTOPK inhibitorPositron emission tomographyIn vivo PET imagingBlocking doseBiodistribution analysisSubcutaneous injectionEx vivo biodistribution analysisPET imagingPositron emission tomography imagingGlioblastoma xenograft modelNSG micePositron emission tomography imaging agentsTumor uptakeU87 glioblastoma cellsXenograft modelTOPK inhibitorsCancer patientsF-18Emission tomographyPreclinical drugsGlioblastoma cellsClinical applicationIn vivoDisease monitoringCalcium Sensor for Photoacoustic Imaging
Roberts S, Seeger M, Jiang Y, Mishra A, Sigmund F, Stelzl A, Lauri A, Symvoulidis P, Rolbieski H, Preller M, Deán-Ben X, Razansky D, Orschmann T, Desbordes S, Vetschera P, Bach T, Ntziachristos V, Westmeyer G. Calcium Sensor for Photoacoustic Imaging. Journal Of The American Chemical Society 2017, 140: 2718-2721. PMID: 28945084, DOI: 10.1021/jacs.7b03064.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent
Adilbay D, Gonzales J, Zazhytska M, Demetrio de Souza Franca P, Roberts S, Viray T, Artschwager R, Patel S, Kodra A, Overdevest J, Chow C, King G, Jain S, Ordonez A, Carroll L, Lomvardas S, Reiner T, Pillarsetty N. Noninvasive Diagnostic Method to Objectively Measure Olfaction and Diagnose Smell Disorders by a Molecularly Targeted Fluorescence Imaging Agent. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266123. PMID: 38960711, PMCID: PMC11294062, DOI: 10.2967/jnumed.123.266123.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLoss of smellSodium channelsConclusion:Methods:Results:Development of therapeutic interventionsSmell disordersTarget sodium channelsMeasured olfactionOlfactory epitheliumOlfactory bulbChronic inflammationClinical studiesSemiquantitative assessmentTherapeutic interventionsProtein levelsMechanisms of olfactionImaging agentsFluorescent imaging agentCoronavirus diseaseOlfactionEpitheliumPatientsInflammationMethods:
2023
Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green
Mc Larney B, Kim M, Roberts S, Skubal M, Hsu H, Ogirala A, Pratt E, Pillarsetty N, Heller D, Lewis J, Grimm J. Ambient Light Resistant Shortwave Infrared Fluorescence Imaging for Preclinical Tumor Delineation via the pH Low-Insertion Peptide Conjugated to Indocyanine Green. Journal Of Nuclear Medicine 2023, 64: 1647-1653. PMID: 37620049, PMCID: PMC10586478, DOI: 10.2967/jnumed.123.265686.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsContrast-to-noise ratioContrast-to-noise ratio valuesTumor delineationOrthotopic breast cancer mouse modelMethods:Indocyanine greenBreast cancer mouse modelPH low insertion peptideTumor screeningClinical translationCancer mouse modelInfrared fluorescence imagingTumor resectionSignal-to-noise ratioClinical trialsMouse modelResectionTumorIndocyanineFluorescence imagingICGPHLIPScreeningMethods:Peptide
Teaching & Mentoring
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- Mentoring
- 7 Mentored Students and Faculty
- 1 Mentee Publication
Mentoring
Riya Mallik
Postdoctoral Associate2024 - PresentAllison Ingman
Research Assistant2024 - 2025Saheed Ayodeji, PhD
Postdoctoral Associate2023 - 2025Chandra Prakash Sharma, PhD
Postdoctoral Associate2023 - 2025
Willing and Available to Mentor
- Clinical Fellows
- Postdoctoral Researchers
- Residents
- Students
Academic Achievements & Community Involvement
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Featured
honor Alavi-Mandell Award
02/01/2022International AwardSociety of Nuclear Medicine and Molecular ImagingDetailsUnited Stateshonor Laura-Bassi Award
02/01/2016Regional AwardTechnical University MunichDetailsGermanyhonor Life Science and Technology Award
02/01/2013Regional AwardTechnical University MunichDetailsGermanyhonor Erasmus+ Mobility Award
02/01/2009Regional AwardEuropean Union-British CouncilDetailsUnited Kingdom
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Get In Touch
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Contacts
Mailing Address
Radiology & Biomedical Imaging
Tompkin's East 2, PO Box 208042
New Haven, Connecticut 06520
United States
Locations
Boardman Building
Lab
330 Cedar Street
New Haven, CT 06510
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