Peng Xu, PhD
Postdoctoral AssociateCards
About
Research
Publications
Featured Publications
An in vivo screen identifies NAT10 as a master regulator of brain metastasis
Chen J, Xu P, Cai W, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop E, Asare E, Zhang Y, Yin M, Tebaldi T, Meier J, Westbrook T, Halene S, Liu Y, Shen H, Nguyen D, Yan Q. An in vivo screen identifies NAT10 as a master regulator of brain metastasis. Science Advances 2025, 11: eads6021. PMID: 40138393, PMCID: PMC11939035, DOI: 10.1126/sciadv.ads6021.Peer-Reviewed Original ResearchConceptsPhosphoserine aminotransferase 1Metastasis in vivoIn vivo screeningRNA helicase domainRegulator of brain metastasisMetastatic breast cancer cellsBrain metastasis in vivoBrain metastasesRNA helicaseCell growth in vitroBreast cancer cellsCancer cell proliferationSerine biosynthesisEpigenetic regulationGrowth in vitroNAT10Migration in vitroCancer cellsTumor growthCell proliferationPrimary tumor growthDrivers of brain metastasesRNACancer metastasisCancer-related deaths
2026
Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma
Suzuki T, Heishima K, Yamazaki J, Yamazaki M, Kinoshita R, Kim S, Hosoya K, Okamatsu-Ogura Y, Sasaki M, Xu P, Yan Q, Kimura T, Aoshima K. Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma. Frontiers In Veterinary Science 2026, 13: 1734339. DOI: 10.3389/fvets.2026.1734339.Peer-Reviewed Original ResearchLysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma
Suzuki T, Heishima K, Yamazaki J, Yamazaki M, Kinoshita R, Kim S, Hosoya K, Okamatsu-Ogura Y, Sasaki M, Xu P, Yan Q, Kimura T, Aoshima K. Lysine lactylation regulates ATF4-mediated stress responses under glucose starvation in canine hemangiosarcoma. Frontiers In Veterinary Science 2026, 13: 1734339. PMID: 41767677, PMCID: PMC12936438, DOI: 10.3389/fvets.2026.1734339.Peer-Reviewed Original ResearchTranscription start siteGlucose-limited conditionsLysine lactylationStress responseGene expressionStress-responsive gene expressionGlucose deprivationStart siteGlucose starvationHistone lactylation levelsTumor cell survivalAsparagine supplementationImmune-related genesCell survivalHistone lactylationHistoneAerobic glycolysisLysineCell proliferationTranscriptionGenesCanine hemangiosarcomaAsparaginePatient tissuesCells
2025
SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity
Chatterjee P, Chakraborty R, Sizer A, O’Brien B, Xu P, Hwa J, Xie Y, Yan Q, Hwa J, Martin K. SUV39H1 Regulates KLF4 and Chromatin Remodeling in Smooth Muscle Cell Phenotypic Plasticity. Arteriosclerosis Thrombosis And Vascular Biology 2025, 45: 2015-2033. PMID: 40836920, DOI: 10.1161/atvbaha.124.322179.Peer-Reviewed Original ResearchVascular Smooth Muscle Cell PlasticityHistone H3 lysine 9Transposase-accessible chromatinH3 lysine 9Vascular smooth muscle cellsSUV39H1 knockdownChromatin accessibilityPhenotypic plasticityLysine 9Smooth muscle cellsArtery smooth muscle cellsGene promoterCoronary artery smooth muscle cellsHuman coronary artery smooth muscle cellsPromoters genome-wideChromatin immunoprecipitation assaysMuscle cellsCell phenotypic plasticityCarotid ligationGenome-wideEpigenetic marksChromatin remodelingSMC gene expressionHistone methylationChromatin immunoprecipitationBisulfite‐free PCDHGB7 methylation in urine enables early noninvasive detection of urothelial carcinoma
Yang Z, Chen Q, Dong S, Xu P, Mao Z, Dong Y, Li W, Li W, Han Y, Dai L, Dong G, Zhang Y, Li Y, Cheng L, Ci W, Yu W, Xu C. Bisulfite‐free PCDHGB7 methylation in urine enables early noninvasive detection of urothelial carcinoma. Bioengineering & Translational Medicine 2025, 10: e70004. PMID: 40708980, PMCID: PMC12284432, DOI: 10.1002/btm2.70004.Peer-Reviewed Original ResearchUrothelial carcinomaNoninvasive detectionDetection of urothelial carcinomaStandard urine cytologyClinical detectionRenal pelvis cancerUC tumorsUrine cytologyMale malignancyPelvis cancerEasy-to-performUreter cancerBladder cancerValidation setPolymerase chain reactionQuantitative polymerase chain reactionPatient enrollmentUrinary systemPatientsUrine samplesUrineCancerEarly detectionChain reactionCarcinoma
2024
Hypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma
Yang Z, Chen Q, Dong S, Xu P, Zheng W, Mao Z, Qian C, Zheng X, Dai L, Wang C, Shi H, Li J, Yuan J, Yu W, Xu C. Hypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma. Journal Of Translational Medicine 2024, 22: 608. PMID: 38956589, PMCID: PMC11218302, DOI: 10.1186/s12967-024-05420-3.Peer-Reviewed Original ResearchConceptsMethodsThe methylation levelsRecurrence monitoringClinical scenariosIndicator of recurrenceBackgroundUrothelial carcinomaClinical recurrenceUrothelial carcinomaBenign diseaseUrological malignanciesPostoperative surveillanceUC diagnosisUC patientsTraining cohortUrothelial markersValidation cohortRecurrenceUrinary systemClinical utilityCarcinomaMethylation markersPatientsUrine samplesTissue samplesUrineDiagnosismiR‐1246 promotes osteosarcoma cell migration via NamiRNA‐enhancer network dependent on Argonaute 2
Yang S, Zou Q, Liang Y, Zhang D, Peng L, Li W, Li W, Liu M, Tong Y, Chen L, Xu P, Yang Z, Zhou K, Xiao J, Wang H, Yu W. miR‐1246 promotes osteosarcoma cell migration via NamiRNA‐enhancer network dependent on Argonaute 2. MedComm 2024, 5: e543. PMID: 38585233, PMCID: PMC10999177, DOI: 10.1002/mco2.543.Peer-Reviewed Original ResearchArgonaute 2Gene activationMiR-1246Gene expressionCell migrationNuclear activating miRNAsOsteosarcoma cellsOsteosarcoma metastasisOsteosarcoma cell migrationMNNG cellsMigratory abilityPAZ domainEnhancer DNAH3K27ac enrichmentMiR-1246 levelActive miRNAsGene transcriptionRNase HMalignant osteosarcoma cellsIn vitro assaysGenesNamiRNAsArgonauteExtracellular vesiclesEnhanced activityPCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study
Cao D, Yang Z, Dong S, Li Y, Mao Z, Lu Q, Xu P, Shao M, Pan L, Han X, Yuan J, Fan Q, Chen L, Wang Y, Zhu W, Yu W, Wang Y. PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study. BMC Medicine 2024, 22: 55. PMID: 38317152, PMCID: PMC10845746, DOI: 10.1186/s12916-024-03267-5.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusHrHPV-positive womenHigh-risk human papillomavirus-positive womenTriage of hrHPV-positive womenCervical intraepithelial neoplasia grade 2Triage strategiesHuman papillomavirus-positive womenInternational Peace Maternity and Child Health HospitalMaternal and Child Health HospitalMortality of cervical cancerChild Health HospitalProspective cohort studyASC-USLSIL cytologyColposcopy referralHealth HospitalCytology testHuman papillomavirusOver-referralCervical cancerCohort studyMethodsA totalGrade 2TriageWomen
2023
Pre-enriched saline gargle samples for detection of SARS-CoV-2
Xu P, Chen J, Qian C, Yu W. Pre-enriched saline gargle samples for detection of SARS-CoV-2. BioScience Trends 2023, 17: 81-84. PMID: 36653152, DOI: 10.5582/bst.2022.01530.Peer-Reviewed Original Research
2022
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing
Dong S, Yang Z, Xu P, Zheng W, Zhang B, Fu F, Mao Z, Yuan J, Chen H, Yu W. Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing. Signal Transduction And Targeted Therapy 2022, 7: 208. PMID: 35790732, PMCID: PMC9256699, DOI: 10.1038/s41392-022-01026-7.Peer-Reviewed Original Research