Peng Xu, PhD
Postdoctoral AssociateCards
About
Research
Publications
2024
Hypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma
Yang Z, Chen Q, Dong S, Xu P, Zheng W, Mao Z, Qian C, Zheng X, Dai L, Wang C, Shi H, Li J, Yuan J, Yu W, Xu C. Hypermethylated TAGMe as a universal-cancer-only methylation marker and its application in diagnosis and recurrence monitoring of urothelial carcinoma. Journal Of Translational Medicine 2024, 22: 608. PMID: 38956589, PMCID: PMC11218302, DOI: 10.1186/s12967-024-05420-3.Peer-Reviewed Original ResearchConceptsRecurrence monitoringMethodsThe methylation levelsIndicator of recurrenceBackgroundUrothelial carcinomaClinical recurrenceUrothelial carcinomaBenign diseaseUrological malignanciesPostoperative surveillanceUC diagnosisUC patientsTraining cohortUrothelial markersValidation cohortRecurrenceClinical scenariosUrinary systemClinical utilityCarcinomaMethylation markersPatientsUrine samplesTissue samplesUrineDiagnosismiR‐1246 promotes osteosarcoma cell migration via NamiRNA‐enhancer network dependent on Argonaute 2
Yang S, Zou Q, Liang Y, Zhang D, Peng L, Li W, Li W, Liu M, Tong Y, Chen L, Xu P, Yang Z, Zhou K, Xiao J, Wang H, Yu W. miR‐1246 promotes osteosarcoma cell migration via NamiRNA‐enhancer network dependent on Argonaute 2. MedComm 2024, 5: e543. PMID: 38585233, PMCID: PMC10999177, DOI: 10.1002/mco2.543.Peer-Reviewed Original ResearchArgonaute 2Gene activationMiR-1246Gene expressionCell migrationActivate gene expressionNuclear activating miRNAsActivate gene transcriptionOsteosarcoma cellsOsteosarcoma metastasisOsteosarcoma cell migrationMNNG cellsPAZ domainEnhancer DNAH3K27ac enrichmentMiR-1246 levelActive miRNAsGene transcriptionRNase HMalignant osteosarcoma cellsIn vitro assaysPromote tumor metastasisNamiRNAsArgonauteExtracellular vesiclesPCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study
Cao D, Yang Z, Dong S, Li Y, Mao Z, Lu Q, Xu P, Shao M, Pan L, Han X, Yuan J, Fan Q, Chen L, Wang Y, Zhu W, Yu W, Wang Y. PCDHGB7 hypermethylation-based Cervical cancer Methylation (CerMe) detection for the triage of high-risk human papillomavirus-positive women: a prospective cohort study. BMC Medicine 2024, 22: 55. PMID: 38317152, PMCID: PMC10845746, DOI: 10.1186/s12916-024-03267-5.Peer-Reviewed Original ResearchConceptsHigh-risk human papillomavirusHrHPV-positive womenHigh-risk human papillomavirus-positive womenCervical intraepithelial neoplasia grade 1Triage of hrHPV-positive womenCervical intraepithelial neoplasia grade 2Triage strategiesHuman papillomavirus-positive womenInternational Peace Maternity and Child Health HospitalMaternal and Child Health HospitalMortality of cervical cancerChild Health HospitalProspective cohort studyASC-USLSIL cytologyColposcopy referralHealth HospitalCytology testHuman papillomavirusOver-referralCervical cancerCohort studyMethodsA totalGrade 2Grade 1
2023
Pre-enriched saline gargle samples for detection of SARS-CoV-2
Xu P, Chen J, Qian C, Yu W. Pre-enriched saline gargle samples for detection of SARS-CoV-2. BioScience Trends 2023, 17: 81-84. PMID: 36653152, DOI: 10.5582/bst.2022.01530.Peer-Reviewed Original Research
2022
Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing
Dong S, Yang Z, Xu P, Zheng W, Zhang B, Fu F, Mao Z, Yuan J, Chen H, Yu W. Mutually exclusive epigenetic modification on SIX6 with hypermethylation for precancerous stage and metastasis emergence tracing. Signal Transduction And Targeted Therapy 2022, 7: 208. PMID: 35790732, PMCID: PMC9256699, DOI: 10.1038/s41392-022-01026-7.Peer-Reviewed Original ResearchHymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression
Yang S, Ling Y, Zhao F, Li W, Song Z, Wang L, Li Q, Liu M, Tong Y, Chen L, Ru D, Zhang T, Zhou K, Zhang B, Xu P, Yang Z, Li W, Song Y, Xu J, Zhu T, Shan F, Yu W, Lu H. Hymecromone: a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression. Signal Transduction And Targeted Therapy 2022, 7: 91. PMID: 35304437, PMCID: PMC8931182, DOI: 10.1038/s41392-022-00952-w.Peer-Reviewed Original ResearchConceptsLesion absorptionCOVID-19 progressionTreat biliary spasmGround-glass opacitiesControl groupC-reactive proteinInhibitor of HA synthesisHyaluronic acidClinical COVID-19Levels of hyaluronanBiliary spasmClinical parametersD-dimerPulmonary lesionsTherapeutic effectPatientsSARS-CoV-2LymphocytesDrugCOVID-19HymecromoneHuman identical sequencesInhibitorsPrescription drugsHA synthesisSARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network
Li W, Yang S, Xu P, Zhang D, Tong Y, Chen L, Jia B, Li A, Lian C, Ru D, Zhang B, Liu M, Chen C, Fu W, Yuan S, Gu C, Wang L, Li W, Liang Y, Yang Z, Ren X, Wang S, Zhang X, Song Y, Xie Y, Lu H, Xu J, Wang H, Yu W. SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network. EBioMedicine 2022, 76: 103861. PMID: 35124429, PMCID: PMC8811534, DOI: 10.1016/j.ebiom.2022.103861.Peer-Reviewed Original ResearchConceptsHuman identical sequencesRNA elementsHuman genomeSARS-CoV-2 genomeHyaluronan synthase 2Chromatin immunoprecipitation assaysDistant genesSequence similarityGenomic fragmentsSequence identityTarget lociGenomic interactionsMiRNA precursorsH3K27ac enrichmentSARS-CoV-2Identical sequencesBioinformatics analysisImmunoprecipitation assaysGenomeGene expressionHEK293TQuantitative RT-PCRShort sequencesGenesHost enhancementHypermethylated PCDHGB7 as a Biomarker for Early Detection of Endometrial Cancer in Endometrial Brush Samples and Cervical Scrapings
Yuan J, Mao Z, Lu Q, Xu P, Wang C, Xu X, Zhou Z, Zhang T, Yu W, Dong S, Wang Y, Cheng W. Hypermethylated PCDHGB7 as a Biomarker for Early Detection of Endometrial Cancer in Endometrial Brush Samples and Cervical Scrapings. Frontiers In Molecular Biosciences 2022, 8: 774215. PMID: 35059435, PMCID: PMC8763697, DOI: 10.3389/fmolb.2021.774215.Peer-Reviewed Original ResearchEndometrial brush samplingEndometrial cancerCervical scrapesBrush samplesMethylation-sensitive restriction enzymesMethylation markersEndometrial tissueNovel methylation markersGene Expression Omnibus (GEODNA methylation markersEarly detection of endometrial cancerDetection of endometrial cancerEarly detection of ECPredictive valueTao Brush samplingMinimally invasive detection methodRestriction enzymesMethylation dataCancer Genome AtlasNegative predictive valueMethylation detectionEndometrial cancer detectionPositive predictive valueEarly detectionMSRE-qPCR
2021
Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network
Liang Y, Lu Q, Li W, Zhang D, Zhang F, Zou Q, Chen L, Tong Y, Liu M, Wang S, Li W, Ren X, Xu P, Yang Z, Dong S, Zhang B, Huang Y, Li D, Wang H, Yu W. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. Nucleic Acids Research 2021, 49: 8556-8572. PMID: 34329471, PMCID: PMC8421228, DOI: 10.1093/nar/gkab626.Peer-Reviewed Original ResearchMeSH KeywordsBreast NeoplasmsCarcinogenesisDNA MethylationEnhancer Elements, GeneticEpigenomicsFemaleGene Expression Regulation, NeoplasticGene SilencingHumansMicroRNAsPromoter Regions, GeneticReceptors, EstrogenReceptors, G-Protein-CoupledRegulatory Sequences, Nucleic AcidRNA, NeoplasmTumor Suppressor ProteinsConceptsTumor suppressor geneLowest expression of miRNABreast cancerLow expressionDysfunction of tumor suppressor genesLoss of function of tumor suppressor genesTriple negative breast cancer subtypeCancer developmentFunction of tumor suppressor genesMiR-339Inactivation of tumor suppressor genesClinical breast cancer treatmentTumor suppressor gene inactivationExpression of miRNAsReactivation of tumor suppressor genesBreast cancer subtypesBreast cancer cellsBreast cancer treatmentLuminal A/BPaired breast cancerAberrant histone modificationsGPER1 expressionEpigenetic abnormalitiesCancer subtypesSuppressor geneUHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner
Xu P, Zhang L, Xiao Y, Li W, Hu Z, Zhang R, Li J, Wu F, Xi Y, Zou Q, Wang Z, Guo R, Ma H, Dong S, Xiao M, Yang Z, Ren X, Wei C, Yu W. UHRF1 regulates alternative splicing by interacting with splicing factors and U snRNAs in a H3R2me involved manner. Human Molecular Genetics 2021, 30: 2110-2122. PMID: 34196368, DOI: 10.1093/hmg/ddab178.Peer-Reviewed Original ResearchConceptsU snRNAsSplicing factorsDNA methylation maintenanceAlternative splicing eventsFunctions of UHRF1RNA splicing regulationAlternative RNA splicingDNA damage repairU2 snRNAMethylation maintenanceProtein interactomeRNA metabolismSplicing regulationRNA splicingSplicing eventsSpliceosome componentsAlternative splicingRNA interactomeUHRF1Chromatin configurationBinding preferencesCell cycleMolecular basisBiological processesMethylation status