Nicola Santoro, MD, PhD
Associate Professor of PediatricsDownloadHi-Res Photo
Cards
Contact Info
Pediatric Endocrinology & Diabetes
330 Cedar Street
New Haven, CT 06511
United States
About
Copy Link
Titles
Associate Professor of Pediatrics
Biography
1993-1999 Student of Medicine at the Second University of Naples (Napoli – Italy)
1997-1999 Intern, Pediatrics, Department of Pediatrics Second University of Napoli (Napoli, Italy)
2000-2005 Resident, Pediatrics, Department of Pediatrics Second University of Napoli (Napoli, Italy)
2003 Visiting Scientist Human Genomics Lab directed by Dr Claude Bouchard at Pennington Biomedical Research Center (Louisiana State University), Baton Rouge, LA, USA.
2005-2008 PhD student of Pharmacology and Respiratory Pathophysiology, at the Second University of Napoli (Napoli, Italy)
2009-2010 Post doctoral research associate, Department of Pediatrics Yale University (New Haven, CT)
2011-2017 Associate Research Scientist, Department of Pediatrics, Yale University (New Haven, CT)
2017-2020 Assistant Professor, Department of Pediatrics, Yale University (New Haven, CT)
2020- Associate Professor, Department of Pediatrics, Yale University (New Haven, CT)
Last Updated on May 15, 2024.
Appointments
Pediatric Endocrinology & Diabetes
Associate Professor on TermPrimary
Other Departments & Organizations
Education & Training
- Post doctoral research associate
- Yale University (2010)
- PhD
- Seconda Universita degli Studi di Napoli (2008)
- Residency
- Seconda Universita' degli Studi di Napoli (2005)
- MD
- Seconda Universita degli Studi di Napoli (1999)
Research
Copy Link
Overview
Our lab focuses on clinical/translational research in pediatric obesity and its complications such as prediabetes and MASLD. We use state-of-the-art techniques such as MRI, MRS, euglycemic and hyperglycemic clamps, stable isotopes infusion, mathematical modeling to study human metabolism and complex diseases pathophysiology.
Medical Research Interests
Metabolic Diseases; Nutrition Disorders
Public Health Interests
Genetics, Genomics, Epigenetics; Metabolism; Child/Adolescent Health; Obesity; Nutrition
ORCID
0000-0001-6437-4173
Research at a Glance
Yale Co-Authors
Frequent collaborators of Nicola Santoro's published research.
Publications Timeline
A big-picture view of Nicola Santoro's research output by year.
Alfonso Galderisi, MD, PhD
Sonia Caprio, MD
Michelle Van Name, MD
Stephanie Samuels, MD
Daniel F Vatner, MD, PhD
Gerald I Shulman, MD, PhD, MACP, MACE, FRCP
41Publications
877Citations
Publications
2025
Biomarkers of glycolysis and the tricarboxylic acid (TCA) cycle in youth with and without obesity.
Refugjati E, Li Z, Umano G, Galuppo B, Van Name M, Samuels S, Kang G, Barbieri E, Hwang J, Santoro N. Biomarkers of glycolysis and the tricarboxylic acid (TCA) cycle in youth with and without obesity. Hormone Research In Paediatrics 2025, 1-13. PMID: 41411205, DOI: 10.1159/000548624.Peer-Reviewed Original ResearchConceptsProton-density fat fractionPlasma concentrationsMetabolic consequencesInsulin resistancePrevalence of childhood obesityAdipose tissue insulin resistanceTissue insulin resistanceType 2 diabetesDevelopment of insulin resistanceLiver proton-density fat fractionExcess adiposityMetabolomic analysisChildhood obesityLevels of glucoseMetabolic dysregulationObesityPlasma concentrations of lactateCardiovascular diseaseFat fractionTricarboxylic acidConcentrations of lactateGlucose utilizationYoung adultsTricarboxylic acid cycle intermediatesAdiposeAltered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue.
Strober J, Ter Horst K, Sung D, Jongejan A, Slusher A, Gassaway B, Tarabra E, Paulo J, Shuken S, Gygi S, Santoro N, Caprio S, Serlie M, Bogan J, Vatner D. Altered Molecular Regulation of TUG Is a Central Feature of Insulin-Resistant Human Adipose Tissue. Diabetes 2025 PMID: 41347935, DOI: 10.2337/db25-0488.Peer-Reviewed Original ResearchConceptsWhite adipose tissueInsulin signalingUBX domainGLUT4 vesiclesSubcutaneous white adipose tissueMolecular regulationInsulin-responsive tissuesExpression of multiple componentsHuman white adipose tissueRegulatory signaling pathwaysGLUT4 translocationAdipose tissueProteomic dataRNA sequencingHuman IRInsulin resistanceSignaling pathwayGLUT4Intracellular poolUbxGlucose uptakeGLUT4 contentQuantitative PCRPathwayBariatric surgery cohortPost-transplant lymphoproliferative disease type Hodgkin lymphoma: limiting toxicity while maximizing efficacy with personalized treatment approach in a rare entity. Experience in a case series.
Brindicci V, Muggeo P, Facchini E, Grassi M, Daniele R, Angarano R, Santoro N, Mascarin M. Post-transplant lymphoproliferative disease type Hodgkin lymphoma: limiting toxicity while maximizing efficacy with personalized treatment approach in a rare entity. Experience in a case series. Klinische Pädiatrie 2025, 237: 374-374. DOI: 10.1055/s-0045-1812940.Peer-Reviewed Original ResearchValidation of a gene signature based on tumor microenvironment composition for risk stratification of pediatric patients with classical Hodgkin lymphoma.Update.
Angarano R, Muggeo P, Grassi M, Daniele R, Loiotine M, Martino R, Gargano G, Ingravallo G, Bellitti E, Opinto G, Vegliante M, Ciavarella S, Pappagallo S, Guarini A, Santoro N. Validation of a gene signature based on tumor microenvironment composition for risk stratification of pediatric patients with classical Hodgkin lymphoma.Update. Klinische Pädiatrie 2025, 237: 385-385. DOI: 10.1055/s-0045-1812969.Peer-Reviewed Original ResearchPsychological and Psychosocial Effects of Cancer on Young Patients and Survivors in Italy: A Mixed-Methods Study on the Challenges and Meaning-Making Factors
Gentile M, Ronconi L, Romeo M, De Vincenzo C, Burattini E, Rutigliano C, Santoro N, Zucchetti G, Fagioli F, Testoni I. Psychological and Psychosocial Effects of Cancer on Young Patients and Survivors in Italy: A Mixed-Methods Study on the Challenges and Meaning-Making Factors. Diseases 2025, 13: 367. PMID: 41294907, PMCID: PMC12650988, DOI: 10.3390/diseases13110367.Peer-Reviewed Original ResearchConceptsYoung adult survivorsPsychological Well-BeingPsychosocial effectsYoung adult survivors of pediatric cancerAdult survivors of pediatric cancerWell-being of pediatric oncology patientsLong-term psychosocial supportEmotional functioningSurvivors of pediatric cancerAdult survivorsLevels of psychological distressPsychological impactResults:Long-term psychological implicationsEffects of cancerPediatric cancerMixed-methods studyPediatric oncology unitConclusions:Quality of lifeExperiences of resilienceSemi-structured interviewsPediatric oncology patientsBiopsychosocial challengesEmotional functioning of childrenIncreased incidence of delayed methotrexate elimination in pediatric patients with Philadelphia-chromosome positive (Ph+) or ABL-class fusion positive (ABL-Class) acute lymphoblastic leukemia treated with imatinib: Results of a retrospective cohort study by the italian association of pediatric hematology-oncology (AIEOP)
Peccatori N, Arnaboldi S, Leoni V, Gaspari S, Parasole R, Santoro N, Pellegrinelli C, Bertorello N, Mattera R, Chiocca E, Russo D, Schumacher R, Guardo D, Spirito A, Mura R, Lovaste S, Monterisi S, Mazzara C, Fazio G, Valsecchi M, De Lorenzo P, Sala A, Colombini A, Spinelli M, Gotti G, Bettini L, Biondi A, Conter V, Balduzzi A, Rizzari C. Increased incidence of delayed methotrexate elimination in pediatric patients with Philadelphia-chromosome positive (Ph+) or ABL-class fusion positive (ABL-Class) acute lymphoblastic leukemia treated with imatinib: Results of a retrospective cohort study by the italian association of pediatric hematology-oncology (AIEOP). Blood 2025, 146: 5095-5095. DOI: 10.1182/blood-2025-5095.Peer-Reviewed Original ResearchConceptsHDMTX coursesHigh-dose methotrexateHDMTX-related toxicityAcute kidney injuryTyrosine kinase inhibitorsAcute lymphoblastic leukemiaHigh-dose methotrexate cyclesConcomitant administrationConcurrent administrationCohort studyTreatment of pediatric acute lymphoblastic leukemiaAIEOP centersConcurrent administration of imatinibAdministration of tyrosine kinase inhibitorsHigh-dose methotrexate administrationRetrospective multicenter cohort studyPediatric acute lymphoblastic leukemiaABL-class fusionsHigh-risk ptsFolinic acid rescueAdministration of imatinibDiscontinuation of imatinibPharmacological effectsSerum MTX levelsFolinic acid administrationBridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation
Carbone F, Després J, Ioannidis J, Neeland I, Garruti G, Busetto L, Liberale L, Ministrini S, Vilahur G, Schindler T, Macedo M, Di Ciaula A, Krawczyk M, Geier A, Baffy G, Faienza M, Farella I, Santoro N, Frühbeck G, Yárnoz‐Esquiroz P, Gómez‐Ambrosi J, Chávez‐Manzanera E, Vázquez‐Velázquez V, Oppert J, Kiortsis D, Sbraccia P, Zoccali C, Portincasa P, Montecucco F. Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation. European Journal Of Clinical Investigation 2025, 55: e70059. PMID: 40371883, PMCID: PMC12257286, DOI: 10.1111/eci.70059.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBody mass indexObesity-related cardiometabolic riskStigma associated with obesityCommunity-level interventionsOptimal care deliveryEffective management of obesityConsensus statementGlobal public health challengeAssociated with chronic diseasesClinical investigationDrivers of obesityPublic health challengePublic health narrativesImprove prevention strategiesCare deliveryManagement of obesityObesity trendsTailored interventionsCollaborative effortsHealth systemCardiometabolic riskGlobal health systemObesity epidemicHealth narrativesChronic diseasesBone Remodeling in Children with Acute Lymphoblastic Leukemia: A Two-Year Prospective Longitudinal Study
Muggeo P, Grassi M, D’Ascanio V, Forte J, Brescia V, Di Serio F, Piacente L, Giordano P, Santoro N, Faienza M. Bone Remodeling in Children with Acute Lymphoblastic Leukemia: A Two-Year Prospective Longitudinal Study. International Journal Of Molecular Sciences 2025, 26: 4307. PMID: 40362542, PMCID: PMC12072470, DOI: 10.3390/ijms26094307.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsMeSH KeywordsAdaptor Proteins, Signal TransducingAdolescentBiomarkersBone RemodelingChildChild, PreschoolFemaleHumansIntercellular Signaling Peptides and ProteinsLongitudinal StudiesMaleOsteocalcinOsteoprotegerinPrecursor Cell Lymphoblastic Leukemia-LymphomaProspective StudiesRANK LigandTartrate-Resistant Acid PhosphataseConceptsTartrate-resistant acid phosphatase-5bAcute lymphoblastic leukemiaAcute lymphoblastic leukemia childrenProspective longitudinal studyLymphoblastic leukemiaBone remodelingDickkopf-1Risk of long-term complicationsEnd-of-inductionChildhood acute lymphoblastic leukemiaControl group of healthy childrenBone turnover markersLevels of CTXGroup of healthy childrenControl groupLong-term complicationsT0-T4Turnover markersChildhood leukemia survivorsHealthy childrenP1NPT0-T1LeukemiaLongitudinal studyOsteoprotegerinATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Slusher A, Santoro N, Vash-Margita A, Galderisi A, Hu P, Tokoglu F, Li Z, Tarabra E, Strober J, Vatner D, Shulman G, Caprio S. ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis. Journal Of Clinical Investigation 2025, 135: e184740. PMID: 40091831, PMCID: PMC11910223, DOI: 10.1172/jci184740.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsHyperinsulinemic-euglycemic clampSubcutaneous adipose tissueInsulin resistanceAdipose triglyceride lipaseInsulin infusionOral glucose tolerance testAbdominal fat distributionGlucose tolerance testMeasuring abdominal fat distributionLower liver fatActivating adipose triglyceride lipaseMetabolic disease riskLiver fat contentEctopic lipid storageFUNDINGThis workAdipose tissue lipolysisInhibition of adipose tissue lipolysisSubcutaneous adipose tissue samplesFat distributionTolerance testInsulin exposureLiver fatInfusionGlycerol turnoverAdipose tissueCefiderocol for severe bloodstream infection by multidrug-resistant Klebsiella pneumoniae in a pediatric patient with acute myeloid leukemia
De Leonardis F, Marasciulo F, Koronica R, Servedio M, Pentassuglia E, Miani V, Dalfino L, Stolfa S, Santoro N. Cefiderocol for severe bloodstream infection by multidrug-resistant Klebsiella pneumoniae in a pediatric patient with acute myeloid leukemia. Pediatric Hematology Oncology Journal 2025, 10: 57-58. DOI: 10.1016/j.phoj.2025.02.003.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Pathophysiology of Nonalcoholic Fatty Liver Disease (NAFLD) in Youth with Obesity
HIC ID2000028731RolePrincipal InvestigatorPrimary Completion Date08/31/2025Recruiting ParticipantsGenderBothAge12 years - 22 yearsStudy to investigate adipocyte cell and lipid turnover in obese adolescents
HIC ID1503015459RoleSub InvestigatorPrimary Completion Date05/01/2025Recruiting ParticipantsGenderBothAge12 years - 21 yearsPrevalence of Carbohydrate Intolerance in Lean and Obese Children
HIC ID9909011190RoleSub InvestigatorPrimary Completion Date09/30/2025Recruiting ParticipantsGenderBothAge8 years - 18 years
Academic Achievements & Community Involvement
Copy Link
Honors
honor Young Investigator Travel Grant Award
06/17/2014National AwardAmerican Diabetes AssociationDetailsUnited Stateshonor Yale Center for Clinical Investigation Scholar
07/01/2012National AwardDetailsUnited Stateshonor Travel Grant
10/12/2010National AwardThe Obesity SocietyDetailsUnited Stateshonor President Poster Award
09/23/2008International AwardEuropean Society for Pediatric EndocrinologyDetailsTurkeyhonor Young Researcher Award
09/01/2000International AwardSecond University of NapoliDetailsItaly
News
Copy Link
News
Get In Touch
Copy Link
Contacts
Academic Office Number
Mailing Address
Pediatric Endocrinology & Diabetes
330 Cedar Street
New Haven, CT 06511
United States