Lourdes Mendez, MD, PhD
Assistant ProfessorCards
About
Research
Publications
2023
Older patients with chronic myeloid leukemia face suboptimal molecular testing and tyrosine kinase inhibitor adherence
Shallis R, Wang R, Zeidan A, Huntington S, Neparidze N, Stempel J, Mendez L, Di M, Ma X, Podoltsev N. Older patients with chronic myeloid leukemia face suboptimal molecular testing and tyrosine kinase inhibitor adherence. Blood Advances 2023, 7: 3213-3224. PMID: 36939371, PMCID: PMC10338212, DOI: 10.1182/bloodadvances.2022009074.Peer-Reviewed Original ResearchConceptsChronic myeloid leukemiaTKI adherenceTKI initiationOlder patientsMyeloid leukemiaEnd Results-Medicare databaseTyrosine kinase inhibitor usePolymerase chain reaction testingQuantitative polymerase chain reaction testingOlder patient populationCare of patientsHealth care accessReal-world studyReal-world evidenceLow socioeconomic statusLow-income subsidyFirst yearInfluenza vaccinationInhibitor useWorse survivalTKI treatmentMultivariable analysisPatient populationOptimal monitoringCare accessClonal Hematopoiesis: Origins and determinants of evolution.
Mendez LM, Patnaik MM. Clonal Hematopoiesis: Origins and determinants of evolution. Leuk Res 2023, 129: 107076. PMID: 37075557, DOI: 10.1016/j.leukres.2023.107076.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSpectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms
Xie Z, Chen E, Mendez L, Komrokji R, Zeidan A. Spectrum From Clonal Hematopoiesis to Myelodysplastic Neoplasm/Syndromes and Other Myeloid Neoplasms. The Cancer Journal 2023, 29: 130-137. PMID: 37195768, DOI: 10.1097/ppo.0000000000000656.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsClonal hematopoiesisHigh-risk patientsRisk of progressionSuch patientsUndetermined significanceAge-related diseasesHematologic malignanciesClonal cytopeniaMyeloid neoplasmsHigh riskUnmet needMyeloid malignanciesNatural historyCH managementPatientsMalignancySignificant knowledge gapsRiskHematopoiesisCytopeniasNeoplasmsSyndromeIpilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings.
Garcia JS, Flamand Y, Penter L, Keng M, Tomlinson BK, Mendez LM, Koller P, Cullen N, Arihara Y, Pfaff K, Wolff JO, Brunner AM, Galinsky I, Bashey A, Antin JH, Cutler C, Ho V, Jonas BA, Luskin MR, Wadleigh M, Winer ES, Savell A, Leonard R, Robertson T, Davids MS, Streicher H, Rodig SJ, Ritz J, Wu CJ, DeAngelo DJ, Neuberg D, Stone RM, Soiffer RJ. Ipilimumab plus decitabine for patients with MDS or AML in posttransplant or transplant-naïve settings. Blood 2023, 141: 1884-1888. PMID: 36332187, DOI: 10.1182/blood.2022017686.Peer-Reviewed Original Research
2022
Is it the time to integrate novel sequencing technologies into clinical practice?
VanOudenhove J, Halene S, Mendez L. Is it the time to integrate novel sequencing technologies into clinical practice? Current Opinion In Hematology 2022, 30: 70-77. PMID: 36602939, DOI: 10.1097/moh.0000000000000754.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNovel sequencing technologiesSequencing technologiesUnprecedented biological insightsNext-generation sequencing techniquesDNA sequencing technologiesHigh-throughput NGSRare cell populationsBiological insightsMultiomics approachSequencing techniquesGenotype-phenotype correlationClonal diversityCellular resolutionMechanistic insightsCell populationsPhenotype correlationMyeloid diseasesClonesClonal hierarchyClonal haematopoiesisResidual clonesInsightsSeqDiversityImproved capture
2021
Circulating Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2-Mutated Myeloproliferative Neoplasms.
Sharda AV, Bogue T, Barr A, Mendez LM, Flaumenhaft R, Zwicker JI. Circulating Protein Disulfide Isomerase Is Associated with Increased Risk of Thrombosis in JAK2-Mutated Myeloproliferative Neoplasms. Clin Cancer Res 2021, 27: 5708-5717. PMID: 34400417, DOI: 10.1158/1078-0432.CCR-21-1140.Peer-Reviewed Original Research
2020
VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2.
Sharda AV, Barr AM, Harrison JA, Wilkie AR, Fang C, Mendez LM, Ghiran IC, Italiano JE, Flaumenhaft R. VWF maturation and release are controlled by 2 regulators of Weibel-Palade body biogenesis: exocyst and BLOC-2. Blood 2020, 136: 2824-2837. PMID: 32614949, DOI: 10.1182/blood.2020005300.Peer-Reviewed Original Research
2019
Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial
Brunner A, Blonquist T, DeAngelo D, McMasters M, Fell G, Hermance N, Winer E, Lindsley R, Hobbs G, Amrein P, Hock H, Steensma D, Garcia J, Luskin M, Stone R, Ballen K, Rosenblatt J, Avigan D, Nahas M, Mendez L, McAfee S, Moran J, Bergeron M, Foster J, Bertoli C, Manning A, McGregor K, Fishman K, Kuo F, Baltay M, Macrae M, Burke M, Behnan T, Wey M, Som T, Ramos A, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg D, Chen Y, Graubert T, Fathi A. Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial. The Lancet Haematology 2019, 7: e122-e133. PMID: 31837959, DOI: 10.1016/s2352-3026(19)30203-0.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaHigh-risk acute myeloid leukemiaTherapy-related acute myeloid leukemiaSecondary acute myeloid leukemiaPhase 2 trialPlatelet count recoveryInduction chemotherapyComplete remissionMyeloid leukemiaUntreated patientsEligible patientsCount recoveryDana-Farber/Harvard Cancer CenterEastern Cooperative Oncology Group performance statusUntreated acute myeloid leukemiaActivity of alisertibAdverse-risk karyotypeCommon grade 3Previous myelodysplastic syndromeTreatment-related deathsProportion of patientsPromising therapeutic targetComposite remissionFebrile neutropeniaOral alisertibThe Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy.
Mendez LM, Posey RR, Pandolfi PP. The Interplay Between the Genetic and Immune Landscapes of AML: Mechanisms and Implications for Risk Stratification and Therapy. Front Oncol 2019, 9: 1162. PMID: 31781488, DOI: 10.3389/fonc.2019.01162.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGermline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.
Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP. Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita. Nat Genet 2019, 51: 1518-1529. PMID: 31570891, DOI: 10.1038/s41588-019-0502-z.Peer-Reviewed Original Research
Clinical Trials
Current Trials
Phase 1 Study to Determine the Safety and Tolerability of Ziftomenib Combinations for the Treatment of KMT2A-rearranged or NPM1-mutant Relapsed/Refractory Acute Myeloid Leukemia
HIC ID2000035900RoleSub InvestigatorPrimary Completion Date08/31/2026Recruiting ParticipantsPhase I/II Open-Label Study to Assess Safety, Tolerability and Preliminary Efficacy of the CLEVER-1 Antibody Bexmarilimab in Combination With Azacitidine or Azacitidine/Venetoclax in Patients With Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia or Acute Myeloid Leukemia
HIC ID2000034403RoleSub InvestigatorPrimary Completion Date12/31/2024Recruiting ParticipantsA Phase 3, Open-label, Randomized Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) vs Epoetin Alfa for the Treatment of Anemia Due to Revised International Prognostic Scoring System (IPSS-R) Very Low, Low, or Intermediate-Risk Myelodysplastic Syndrome (MDS) in Erythropoiesis-Stimulating Agent (ESA)-Naive Participants Who Are Non-Transfusion Dependent (NTD): The "ELEMENT-MDS" Trial
HIC ID2000035577RoleSub InvestigatorPrimary Completion Date06/25/2027Recruiting ParticipantsA Phase 1/2 First in Human Study of the Menin-MLL(KMT2A) Inhibitor KO-539 in Patients With Relapsed or Refractory Acute Myeloid Leukemia
HIC ID2000034410RoleSub InvestigatorPrimary Completion Date06/01/2025Recruiting ParticipantsA Phase 1/2 Open Label, Multicenter, Dose Escalation and Expansion Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML)
HIC ID2000032345RoleSub InvestigatorPrimary Completion Date02/29/2024Recruiting Participants
Academic Achievements & Community Involvement
Clinical Care
Overview
Lourdes Mendez, MD, PhD, is a hematologic oncologist specializing in the treatment of leukemia, particularly acute lymphoblastic leukemia.
As an assistant professor at Yale School of Medicine, Dr. Mendez is involved in research that seeks to develop new therapeutic options for leukemia and myeloid disorders (a group of blood cancers that affect the bone marrow’s ability to produce healthy blood cells). Her research aims to translate laboratory findings into clinical applications to enhance patient care.
Dr. Mendez received her medical training from Albert Einstein College of Medicine and completed her residency at Weill Cornell-New York Presbyterian. She pursued a fellowship in hematology and oncology at Beth Israel Deaconess Medical Center, where she also completed a postdoctoral fellowship in cancer genetics.
Clinical Specialties
Hematology; Hematologic Oncology
Fact Sheets
Acute Myeloid Leukemia (AML)
Learn More on Yale MedicineDiagnosing Leukemia
Learn More on Yale MedicineCytogenic Studies for Leukemia Diagnosis
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Yale Medicine News
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News
- March 31, 2025
Yale’s Post ASH Review: Highlights from the 2024 American Society of Hematology Annual Meeting
- March 25, 2024
Yale’s Post ASH Review
- September 11, 2023
Dr. Lourdes Mendez on Yale Cancer Answers
- October 24, 2022
Yale Hematology Welcomes Two Hematologists
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