Voluntary Faculty are clinicians or other professionals who contribute significantly to Yale School of Medicine's educational programs but are not employed by the school.
Voluntary rank detailsLisa Marie Harding
Assistant Clinical ProfessorAbout
Copy Link
Titles
Assistant Clinical Professor, Yale Department of Psychiatry
Biography
Lisa Harding MD, Board Certified Psychiatrist and depression expert is specially trained in providing all treatment types for depression. She completed her residency in Psychiatry as the Chief of Interventional Psychiatry at the Yale School of Medicine. She has completed over 4000 procedures in Electroconvulsive therapy (ECT), IV Ketamine, Spravato and Transcranial Magnetic Stimulation (TMS). She is also experienced in managing complex medication regimen and skilled in various psychotherapy methods. She is also very active in the American Psychiatric Association as a Foundation Ambassador and was once a Diversity Leadership Fellow as well as an American Academy of Psychiatry and the Law Rappeport Fellow, both of which are distinguished national fellowship awards offered to the top 1% of resident psychiatrists.
Appointments
Research
Copy Link
Research at a Glance
Yale Co-Authors
Publications Timeline
AZA Allsop
Ilse Wiechers, MD, MPP, MHS
Publications
2025
Music mindfulness acutely modulates autonomic activity and improves psychological state in anxiety and depression
Ramirez C, Alayine G, Akafia C, Adichie K, Watts D, Galdamez Y, Harding L, Allsop A. Music mindfulness acutely modulates autonomic activity and improves psychological state in anxiety and depression. Frontiers In Neuroscience 2025, 19: 1554156. PMID: 40264912, PMCID: PMC12013341, DOI: 10.3389/fnins.2025.1554156.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMusical mindSymptoms of anxietyMindfulness sessionsMusic listeningMusicImproved psychological stateHeart rate variabilityModerate symptoms of anxietyPsychological stateStates of consciousnessParticipants’ psychological statesMindfulnessSelf-reported sexDepressive symptomsLive sessionsStress managementMeasures of heart rate variabilitySocial connectionsIncreased HRVReduce stressEEG power spectral densityPsychological effectsAnxietyDepressionParticipantsHealth Care Resource Use and Medical Costs Among Patients With Major Depressive Disorder and Acute Suicidal Ideation or Behavior Initiated on Esketamine Nasal Spray or Traditional Treatments in the United States
. Health Care Resource Use and Medical Costs Among Patients With Major Depressive Disorder and Acute Suicidal Ideation or Behavior Initiated on Esketamine Nasal Spray or Traditional Treatments in the United States. Clinical Therapeutics 2025, 47: 189-195. PMID: 39757035, DOI: 10.1016/j.clinthera.2024.12.006.Peer-Reviewed Original ResearchCitations
2024
Difficult to Treat Depression: Focus on Approach, Algorithms, and Access.
Karp J, Brinton R, Fournier J, Harding L, Jha M, Lenze E, Mathew S, Meltzer-Brody S, Mohr D, Riva-Posse P, Wiechers I, Williams N. Difficult to Treat Depression: Focus on Approach, Algorithms, and Access. The Journal Of Clinical Psychiatry 2024, 85 PMID: 39630090, DOI: 10.4088/jcp.psprmdd2408ah.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTreating depressionSpectrum of clinical severityTreatment of depressionEvolving treatment landscapeDepartment of PsychiatryBurden of depressionOral pharmacotherapyTreatment landscapeAdult patientsClinical severityCommunity health agenciesDepressionIncreased prevalenceHealth care systemPatientsDepression carePsychiatric workforcePsychiatryPatient advocatesCare systemTherapeutic engineeringHealth agenciesTelemedicine platformDo IRemissionUnderstanding profiles of patients with treatment-resistant depression by stringency of health plan prior authorization criteria for approval of esketamine nasal spray
. Understanding profiles of patients with treatment-resistant depression by stringency of health plan prior authorization criteria for approval of esketamine nasal spray. Current Medical Research And Opinion 2024, 40: 1615-1623. PMID: 39034772, DOI: 10.1080/03007995.2024.2380743.Peer-Reviewed Original ResearchCitationsKetamine Study Prioritizes Equitable Enrollment
https://doi.org/10.1176/appi.pn.2024.06.6.8Publications for non-academic audiencesTreatment Patterns, Acute Healthcare Resource Use, and Costs of Patients with Treatment-Resistant Depression Completing Induction Phase of Esketamine in the United States
. Treatment Patterns, Acute Healthcare Resource Use, and Costs of Patients with Treatment-Resistant Depression Completing Induction Phase of Esketamine in the United States. Drugs - Real World Outcomes 2024, 11: 209-219. PMID: 38727888, PMCID: PMC11176151, DOI: 10.1007/s40801-024-00425-2.Peer-Reviewed Original ResearchCitationsBarriers to Esketamine Nasal Spray Treatment Among Adults With Treatment-Resistant Depression.
. Barriers to Esketamine Nasal Spray Treatment Among Adults With Treatment-Resistant Depression. The Journal Of Clinical Psychiatry 2024, 85 PMID: 38722197, DOI: 10.4088/jcp.23m15102.Peer-Reviewed Original ResearchCitationsManaging Treatment-Resistant Depression: Tips for the Outpatient Psychiatrist
Harding, L, Managing Treatment-Resistant Depression: Tips for the Outpatient Psychiatrist March 20, 2024, News, Article. Psychiatric TimesVol 41, Issue 3Commentaries, Editorials and Letters
2023
Regulating Ketamine Use in Psychiatry.
Harding L. Regulating Ketamine Use in Psychiatry. J Am Acad Psychiatry Law 2023, 51: 320-325. PMID: 37657825, DOI: 10.29158/JAAPL.230040-23.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSocial determinants and distance from certified treatment centers are associated with initiation of esketamine nasal spray among patients with challenging-to-treat major depressive disorder
Liberman J, Pesa J, Rui P, Joshi K, Harding L. Social determinants and distance from certified treatment centers are associated with initiation of esketamine nasal spray among patients with challenging-to-treat major depressive disorder. Medicine 2023, 102: e32895. PMID: 36800597, PMCID: PMC9935983, DOI: 10.1097/md.0000000000032895.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTreatment-resistant depressionSuicidal ideationTreatment centersSocial determinantsAssociated with substance use disordersEsketamine nasal spraySubstance use disordersCare providersSocial determinants of healthLikelihood of discontinuationDepressive disorderAssociated with initiationPatient engagement strategiesDeterminants of healthProviders per capitaSocial determinant variablesPrimary care providersUse disorderHealth care providersHealth care utilizationEsketaminePropensity-score matched controlsPsychiatric careLow likelihoodDepression
Academic Achievements & Community Involvement
Copy Link
Activities
activity Advanced Treatments, Limited Reach: Access in Interventional Psychiatry
07/12/2024 - 07/12/2024LectureSouthwest Forum of Difficult to Treat DepressionDetailsScottsdale, AZ, United StatesSponsored by University of ArizonaAbstract/Synopsishttps://www.psychiatrist.com/jcp/access-in-interventional-psychiatry/
activity Psychiatric Intervention Procedures-the new standard of care
10/22/2022 - 10/22/2022Oral PresentationAAPL- American Academy of Psychiatry and the LawDetailsNew Orleans, LA, United StatesAbstract/SynopsisCurrent approach to care of depressed patient in the community Esketamine: Model of Care and Delivery of Intervention Services in the community Ketamine: Model of Care and Delivery of Intervention Services in the community
activity Factors associated with Completion after the Induction Phase and Persistence Esketamine Nasal Spray
09/17/2022 - 09/20/2022Poster PresentationPsych Congress 2022DetailsNew Orleans, LA, United Statesactivity Psychiatric Intervention Procedures- is this the future?
08/23/2022 - PresentLectureUniversity of Kansas Grand RoundsDetailsWichita, KS, United StatesSponsored by University of Kansas School of Medicineactivity Esketamine: Access to Care
06/09/2022 - 06/12/2022LectureASKP3- American Society of Ketamine Physicians, Psychotherapists & PractitionersDetailsAustin, TX, United States
Honors
honor Irma Bland Award for Excellence in Teaching Residents
09/01/2023National AwardAmerican Psychiatric AssociationDetailsUnited States
News
Copy Link
News
- April 09, 2025
Yale Study: Music Mindfulness May Treat Symptoms of Anxiety and Depression
- February 27, 2025
Harding: Addressing Unmet Needs in Adult African American/Black Adult Patients With Treatment-Resistant Depression
- January 07, 2025
Berman, Harding New Co-Chairs of Yale Psychiatry Alumni Association
- May 08, 2024Source: Psychiatric Times
Managing Treatment-Resistant Depression: Tips for the Outpatient Psychiatrist
Get In Touch
Copy Link