About
Research
Publications
2022
COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers
Olson K, Fogelman N, Maturo L, Alvarado J, Ball S, Forray A, Hu M, Ivy M, Kapo J, Krystal J, Mayes L, Rohrbaugh R, Southwick S, Tebes J, Wassel B, Sinha R. COVID-19 Traumatic Disaster Appraisal and Stress Symptoms Among Health Care Workers. Journal Of Occupational And Environmental Medicine 2022, 64: 934-941. PMID: 35959912, PMCID: PMC9640251, DOI: 10.1097/jom.0000000000002673.Peer-Reviewed Original ResearchConceptsHealth care workersCare workersChronic mental healthCross-sectional evaluationTotal Worker HealthAdverse psychological outcomesPredictive factorsSevere stress eventsResponse rateCare qualityMental healthAdverse effectsPrivate practitionersHigh levelsWorkers' healthSense of controlStress symptomsPsychological outcomesLevel of educationGreater proportionHealthPandemicStress eventsSymptomsWorkers
2008
Visual Analysis of the Yeast 5S rRNA Gene Transcriptome: Regulation and Role of La Protein
French SL, Osheim YN, Schneider DA, Sikes ML, Fernandez CF, Copela LA, Misra VA, Nomura M, Wolin SL, Beyer AL. Visual Analysis of the Yeast 5S rRNA Gene Transcriptome: Regulation and Role of La Protein. Molecular And Cellular Biology 2008, 28: 4576-4587. PMID: 18474615, PMCID: PMC2447126, DOI: 10.1128/mcb.00127-08.Peer-Reviewed Original ResearchConceptsActive genesLa proteinPolymerase loadingRNA polymerase III genesYeast La proteinGrowth conditionsGene copy numberTranscription terminationDifferent growth conditionsShort genesRNA polymeraseGene transcriptomeRRNA geneMiller chromatinGenesMore polymerasesCopy numberElongation rateLHP1First quantitative analysisPolymeraseProteinRegulationFourfold rangeTranscriptomeCompetition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation
Copela LA, Fernandez CF, Sherrer RL, Wolin SL. Competition between the Rex1 exonuclease and the La protein affects both Trf4p-mediated RNA quality control and pre-tRNA maturation. RNA 2008, 14: 1214-1227. PMID: 18456844, PMCID: PMC2390804, DOI: 10.1261/rna.1050408.Peer-Reviewed Original ResearchConceptsLa proteinQuality control pathwaysPre-tRNA maturationRNA quality controlWild-type cellsChoice of pathwaySRP RNAExonucleolytic trimmingAberrant RNAsDefective RNAsMutant yeastFunctional RNAsMajor exonucleaseNoncoding RNAsControl pathwaysRNAExonucleaseTrf4pProteinYeastPathwayCellsNascentAccumulationMaturation
2006
The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability
Copela LA, Chakshusmathi G, Sherrer RL, Wolin SL. The La protein functions redundantly with tRNA modification enzymes to ensure tRNA structural stability. RNA 2006, 12: 644-654. PMID: 16581807, PMCID: PMC1421099, DOI: 10.1261/rna.2307206.Peer-Reviewed Original ResearchConceptsModification enzymesArginyl-tRNA synthetaseFission yeastPseudouridine synthasesTRNA decayTRNA modificationsEfficient biogenesisFunctional redundancyProtein functionMutant tRNAsLa proteinTRNA synthetaseYeast cellsTRNABiogenesisMultiple pathwaysProteinPresence of mutationsMutationsEnzymePathwayPUS4Trf4pGrowthPUS3
Academic Achievements & Community Involvement
Get In Touch
Contacts
Mailing Address
Office of Communications
2 Science Park, 50 Division Street
New Haven, CT 06511
United States
Locations
Office of Communications
Academic Office
2 Science Park
50 Division Street, Fl 2nd
New Haven, CT 06511