Martin Kauke-Navarro, MD
Hospital ResidentDownloadHi-Res Photo
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Hospital Resident
Biography
MD, University of Cologne School of Medicine, Germany;
Dr. med (GER), University of Cologne School of Medicine, Germany;
Research Fellowship: BWH, Harvard Medical School;
Hometown: Cologne, Germany
Last Updated on June 24, 2024.
Departments & Organizations
Education & Training
- General Surgery Resident
- Brigham and Women's Hospital/Harvard Medical School (2022)
- Clinical Fellow
- Brigham and Women's Hospital/Harvard Medical School (2022)
- Research Fellow
- Brigham and Women's Hospital/Harvard Medical School (2021)
- MD
- University of Cologne (2017)
Research
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Overview
Google Scholar: Martin Kauke-Navarro, MD
Loop Profile: https://loop.frontiersin.org/people/763958
Medical Research Interests
Breast Implants; Microsurgery; Vascularized Composite Allotransplantation
ORCID
0000-0001-5399-4166
Research at a Glance
Yale Co-Authors
Frequent collaborators of Martin Kauke-Navarro's published research.
Publications Timeline
A big-picture view of Martin Kauke-Navarro's research output by year.
Research Interests
Research topics Martin Kauke-Navarro is interested in exploring.
Bohdan Pomahac, MD
Sam Boroumand, MD, MHS
Omar Allam, MD
Siba Haykal, MD, PhD, FRCS, FACS
Richard Formica, MD
Michael Alperovich, MD, MSc, FACS
176Publications
2,007Citations
Vascularized Composite Allotransplantation
Microsurgery
Publications
Featured Publications
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatientsFull facial retransplantation in a female patient—Technical, immunologic, and clinical considerations
Kauke M, Panayi AC, Safi A, Haug V, Perry B, Kollar B, Nizzi M, Broyles J, Annino DJ, Marty FM, Sinha I, Lian CG, Murphy GF, Chandraker A, Pomahac B. Full facial retransplantation in a female patient—Technical, immunologic, and clinical considerations. American Journal Of Transplantation 2021, 21: 3472-3480. PMID: 34033210, DOI: 10.1111/ajt.16696.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsChronic antibody-mediated rejectionPatient underwent retransplantationRecurrent cellular rejectionAntibody-mediated rejectionImmediate postoperative phaseInterposition vein graftAllograft lossCellular rejectionFirst allograftOlder allograftsRejection episodesUnderwent retransplantationSecond transplantationFirst transplantPostoperative outcomesAllotransplant recipientsPostoperative phaseVein graftsHyperacute rejectionFacial nerveOutcomes 6Arterial anastomosisRetransplantationSurgical techniquePsychosocial managementFace Transplantation in a Black Patient — Racial Considerations and Early Outcomes
Kauke M, Panayi AC, Tchiloemba B, Diehm YF, Haug V, Kollar B, Perry B, Singhal D, Sinha I, Riella LV, Annino DJ, Pomahac B. Face Transplantation in a Black Patient — Racial Considerations and Early Outcomes. The New England Journal Of Medicine 2021, 384: 1075-1076. PMID: 33730460, PMCID: PMC8182672, DOI: 10.1056/nejmc2033961.Peer-Reviewed Original ResearchCitationsAltmetric
2026
Impact of reduced bone mineral density and osteoporosis on outcomes of orthognathic surgery: A systematic review
Stucki L, Hönigl A, Schwab J, Kauke-Navarro M, Safi A. Impact of reduced bone mineral density and osteoporosis on outcomes of orthognathic surgery: A systematic review. Advances In Oral And Maxillofacial Surgery 2026, 21: 100611. DOI: 10.1016/j.adoms.2025.100611.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeDual-energy X-ray absorptiometryBone mineral densityCone-beam computed tomographyLow bone mineral densityOrthognathic surgeryAntiresorptive drugsMaxillomandibular advancementMineral densityHounsfield unitsOutcomes of orthognathic surgeryOsteotomy siteSleep apnea syndromeX-ray absorptiometrySurgical treatment optionsTitanium osteosynthesis platesSystematic reviewApnea syndromeAntiresorptive therapyPostoperative complicationsSurgical outcomesSurgical challengeTreatment optionsCase reports/seriesRelapse tendencyComparative performance of the nutritional risk index and modified 5-item frailty index in predicting surgical outcomes: A multi-institutional analysis of 9.7 million patients
Knoedler S, Friedrich S, Hu K, Knoedler L, Schaschinger T, Klimitz F, Iske J, Hundeshagen G, Panayi A, Kim B, Kauke-Navarro M, Diatta F, Pomahac B. Comparative performance of the nutritional risk index and modified 5-item frailty index in predicting surgical outcomes: A multi-institutional analysis of 9.7 million patients. Clinical Nutrition 2026, 56: 106536. DOI: 10.1016/j.clnu.2025.11.020.Peer-Reviewed Original ResearchAltmetricConceptsNutritional Risk IndexModified 5-item frailty indexPreoperative risk stratificationArea under the receiver operating characteristic curveMFI-5Unplanned reoperationSurgical complicationsSurgical outcomesRisk stratificationMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseAmerican CollegeQuality Improvement Program databaseMulti-institutional analysisReceiver operating characteristic curveSurgical decision-makingFrailty indexOperating characteristics curveComplication ratePostoperative complicationsSurgical cohortProgram databasePatient counseling
2025
Early outcomes and risk factors in open reduction and internal fixation of mandibular fractures in adults: a 15-Year multi-institutional analysis of 2,705 cases
Alfertshofer M, Knoedler L, Koerdt S, Panayi A, Knoedler S, Allam O, Schaschinger T, Schmitz A, Voss J, Steffen C, Heiland M, Kauke-Navarro M. Early outcomes and risk factors in open reduction and internal fixation of mandibular fractures in adults: a 15-Year multi-institutional analysis of 2,705 cases. Oral And Maxillofacial Surgery 2025, 30: 7. PMID: 41413353, DOI: 10.1007/s10006-025-01490-9.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsMethodsThe American CollegeMandibulomaxillary fixationInternal fixationMandibular fracturesComplication rateMethodsThe American College of Surgeons National Surgical Quality Improvement Program databaseOpen reductionAmerican College of Surgeons National Surgical Quality Improvement Program databaseInternal fixation of mandibular fracturesSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databasePredictors of early complicationsFixation of mandibular fracturesHigher rate of complicationsRate of surgical complicationsTreatment of mandibular fracturesQuality Improvement Program databaseRisk factorsHigher wound classPreoperative blood valuesRobust risk stratificationPostoperative complication rateHigh-risk patientsMulti-institutional analysisRate of complicationsImmunosuppressive and antiinfectious regimens in vascular composite allograft recipients—a systematic review
Knoedler L, Niederegger T, Schaschinger T, Hundeshagen G, Gonzalez J, Knoedler S, Kauke-Navarro M, Iske J, Cetrulo C, Jeljeli M, Hofmann E, Heiland M, Koerdt S, Lellouch A. Immunosuppressive and antiinfectious regimens in vascular composite allograft recipients—a systematic review. Frontiers In Transplantation 2025, 4: 1714886. DOI: 10.3389/frtra.2025.1714886.Peer-Reviewed Original ResearchAltmetricConceptsVascularized Composite AllotransplantationInfection prophylaxisImmunosuppressive regimensMycophenolate mofetilGraft survivalSide effectsEffects of immunosuppressive drugsLong-term graft survivalFacial Vascularized Composite AllotransplantationSide effects of immunosuppressive drugsInclusion criteriaSystematic reviewAntithymocyte globulinImmunosuppressive therapyMaintenance therapyRejection episodesImmunosuppressive protocolsImmunosuppressive strategiesImmunosuppressive drugsLifelong immunosuppressionClinical successPostoperative yearInsufficient therapyMitigate rejectionInduction drugsKeratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders
Klimitz F, Shen Y, Repetto F, Brown S, Knoedler L, Ko C, Abu Hussein N, Crisler W, Adams T, Kaminski N, Lian C, Murphy G, Hsia H, Pomahac B, Kauke-Navarro M. Keratinocytes as active regulators of cutaneous and mucosal immunity: a systematic review across inflammatory epithelial disorders. Frontiers In Immunology 2025, 16: 1694066. DOI: 10.3389/fimmu.2025.1694066.Peer-Reviewed Original ResearchAltmetricConceptsLichen planusLupus erythematosusAtopic dermatitisBullous pemphigoidMucosal inflammationInflammatory dermatosesSystematic reviewGraft-versus-host diseaseDisease-specific pathwaysImmune-mediated skin diseaseOral lichen planusTh2-skewed responseImmune cell recruitmentRegulation of immunityType I interferonSystematic review of studiesEpithelial disordersMucosal involvementEpithelial injuryImmune profileAlloimmune mechanismAntigen presentationGVHDChemokine releaseMucosal keratinocytesSentinel flaps reflect key inflammatory aspects of human face transplant rejection
Crisler W, Win T, Kauke-Navarro M, Zhan Q, Barrera V, Sui S, Laga A, Teague J, Riella L, Azzi J, Pomahac B, Clark R. Sentinel flaps reflect key inflammatory aspects of human face transplant rejection. American Journal Of Transplantation 2025 PMID: 41407105, DOI: 10.1016/j.ajt.2025.12.009.Peer-Reviewed Original ResearchConceptsVascularized Composite AllograftsFacial allograftAntigen-specific T-cell activationInflammatory aspectsT-cell receptor sequencingT cell clonesT cell activationMultiple skin biopsiesMonitoring of rejectionImmunoregulatory genesTransplant rejectionSkin biopsiesImmune eventsImmune rejectionTCRB genesEarly diagnosisPro-inflammatoryCytotoxic injuryFace transplantationComposite allograftsNon-rejectionFlapReceptor sequencesBiopsyAllograftNational Epidemiologic Trends and Disparities in Operative Management of Pediatric Facial Soft Tissue Injuries.
Kong V, Salib A, Rancu A, Parker E, Kauke-Navarro M, Hu K, Moscarelli J, Allam O, Alperovich M. National Epidemiologic Trends and Disparities in Operative Management of Pediatric Facial Soft Tissue Injuries. Journal Of Craniofacial Surgery 2025 PMID: 41348712, DOI: 10.1097/scs.0000000000012265.Peer-Reviewed Original ResearchConceptsFacial soft tissue injuriesSoft tissue injuriesTissue injuryPediatric facial traumaStandard referral pathwayHigh-energy trauma mechanismPatients aged 0Plastic surgery involvementMotor vehicle accidentsSurgical delayAesthetic outcomesOperative treatmentRetrospective studyFacial traumaNational-level analysisTrauma mechanismMultivariate regression modelOperative timeACS TQIPEpidemiological trendsReferral pathwaysAsian childrenAged 0InjuryRacial disparities
Academic Achievements & Community Involvement
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Honors
honor Travel Award
11/05/2022International AwardAmerican Society for Reconstructive TransplantationDetailsUnited Stateshonor Research Grant
04/01/2020Other AwardBrigham and Women's HospitalDetailsUnited Stateshonor Research Grant
01/01/2019International AwardGerman Research FoundationDetailsUnited States
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