Jung Kim, MD
Professor Emeritus of and Senior Research Scientist in PathologyCards
Appointments
Contact Info
About
Titles
Professor Emeritus of and Senior Research Scientist in Pathology
Appointments
Pathology
EmeritusPrimary
Other Departments & Organizations
- Neural Transplant and Neurobehavior Program
- Pathology
- Pathology Research
- Pituitary Program
Education & Training
- MD
- Pusan National University (1964)
Board Certifications
Neuropathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1983
Anatomic & Clinical Pathology
- Certification Organization
- AB of Pathology
- Original Certification Date
- 1976
Research
Overview
Hippocampal sclerosis (neuronal loss and gliosis) plays a complicated role in epilepsy: hippocampal sclerosis occurs due to epilepsy, but, in turn, the sclerotic hippocampus appears to be responsible for epileptogenesis. We are looking into the role of hippocampal neurons and glial cells in epilepy through neuronal and glial density studies in surgically resected hippocampi from intractable epilepsy patients. My second research interest is the role of calpains in CNS degenerative disorders, epilepsy and AIDS. All three conditions just mentioned are believed to have neuronal damages, at least in part, due to excitotoxicity, which may acitivate calpains, a family of Ca++ dependent proteases. Calpains, once activated, cleave spectrin, generating the spectrin breakdown product (BDP), and involvement of calpains is determined by detecting spectrin BDP in the CNS tissue.
ORCID
0000-0002-6031-3629
Research at a Glance
Yale Co-Authors
Publications Timeline
Nihal DeLanerolle, DPhil, DSc
Publications
2024
Immune microenvironmental heterogeneity according to tumor DNA methylation phenotypes in microsatellite instability-high colorectal cancers
Kim J, Hong J, Lee J, Jung M, Choi E, Cho N, Kang G, Kim S. Immune microenvironmental heterogeneity according to tumor DNA methylation phenotypes in microsatellite instability-high colorectal cancers. Cancer Immunology, Immunotherapy 2024, 73: 215. PMID: 39235590, PMCID: PMC11377388, DOI: 10.1007/s00262-024-03805-3.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsProgrammed death-ligand 1Tumor-infiltrating lymphocytesMicrosatellite instability-high colorectal cancerCombined positive scoreTumor proportion scoreTumor mutational burdenCD8+ tumor-infiltrating lymphocytesMicrosatellite instability-highTumor-infiltrating immune cellsCpG island methylator phenotypeColorectal cancerCIMP-high tumorsDensity of CD8+ tumor-infiltrating lymphocytesProgrammed death-ligand 1 tumor proportion scoreCIMP-highConsensus molecular subtype 1Cytolytic activity scoreWhole-slide immunohistochemistryDeath-ligand 1Tumor immune microenvironmentMethylator phenotypeMicrosatellite instability-high tumorsTumor DNA methylationDNA methylation phenotypeCpG island methylator phenotype status
2011
Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model
de Lanerolle NC, Bandak F, Kang D, Li AY, Du F, Swauger P, Parks S, Ling G, Kim JH. Characteristics of an Explosive Blast-Induced Brain Injury in an Experimental Model. Journal Of Neuropathology & Experimental Neurology 2011, 70: 1046-1057. PMID: 22002430, DOI: 10.1097/nen.0b013e318235bef2.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsBrain injuryAxonal injuryÎ’-amyloid precursor protein immunohistochemistryAnesthetized Yorkshire swineBlast-Induced Brain InjuryMild traumatic brain injuryPrecursor protein immunohistochemistryTraumatic brain injuryBlast injury modelAstrocyte activationNeuronal injuryNeuropathologic changesIntracranial hemorrhageNeuropathologic consequencesProtein immunohistochemistryHistologic changesNeurobehavioral outcomesInjury modelPathologic changesSham controlsMood disordersInjuryYorkshire swineExperimental modelHuman brain
2001
Pathology of epilepsy.
Kim JH. Pathology of epilepsy. Experimental And Molecular Pathology 2001, 70: 345-67. PMID: 11418013, DOI: 10.1006/exmp.2001.2372.Peer-Reviewed Original Research
1999
Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy
Spencer S, Kim J, DeLanerolle N, Spencer D. Differential Neuronal and Glial Relations with Parameters of Ictal Discharge in Mesial Temporal Lobe Epilepsy. Epilepsia 1999, 40: 708-712. PMID: 10368067, DOI: 10.1111/j.1528-1157.1999.tb00767.x.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsGlial densityTemporal lobe epilepsyNeuronal densitySpontaneous seizuresLobe epilepsyIctal dischargesSeizure onsetMesial temporal lobe epilepsyElectrical seizure durationHippocampal seizure onsetPercentage of seizuresInterictal-ictal transitionEEG recordingsSeizure durationSeizure parametersPatient's seizuresSeizure propagationPathologic analysisHippocampal fieldsEpilepsy pathogenesisIntracranial EEG recordingsTL resectionSeizuresSynaptic changesPatients
1990
Verbal memory impairment correlates with hippocampal pyramidal cell density.
Sass K, Spencer D, Kim J, Westerveld M, Novelly R, Lencz T. Verbal memory impairment correlates with hippocampal pyramidal cell density. Neurology 1990, 40: 1694-7. PMID: 2234424, DOI: 10.1212/wnl.40.11.1694.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsTemporal seizure focusSeizure focusMemory impairmentSurgical removalMesial temporal lobe structuresMesial temporal structuresPyramidal cell densityGranule cell layerHippocampal subfields CA1Temporal lobe structuresVerbal memory impairmentRefractory epilepsySelective Reminding TestHilar areaImpairment correlatesTemporal lobeBlinded observersSubfields CA1Cell countArea dentataVolumetric cell densityPatientsLobe structuresImpairmentVerbal Selective Reminding Test
Others
- Wong, J.H., Kim, J.H., Awad, I.A. Pathological features of spinal vascular malformations. (Chapter 2). In:Spinal vascular malformations. Barrow, D.L. and Awad, I.A. (eds). Am. Assoc. Neurol. Surgeons, Park Ridge, pp9-22, 1999.Peer-Reviewed Original Research
- Hatanpaa, KJ, Kim JH. Neuropathology of Viral Infections (Chapter 8) in Handbook of Clinical Neurology, Vol. 123 (3rd Series), Aminoff, M, Boller, R and Swaab, D (eds), Tselis AC & Booss, J. (Volume Eds) Elsevier, 175-192, 2014Peer-Reviewed Original Research
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Department of Pathology
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Lauder Hall
310 Cedar Street, Ste LH 219B
New Haven, CT 06510
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203.737.1064Appointments
203.785.6463