Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsJames Samuel, MD
Assistant Clinical ProfessorAbout
Research
Publications
2025
CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death
Arunima A, Niyakan S, Butler S, Clark S, Pinson A, Kwak D, Case E, Qian X, de Figueiredo P, van Schaik E, Samuel J. CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death. Nature Communications 2025, 16: 7493. PMID: 40796858, PMCID: PMC12344041, DOI: 10.1038/s41467-025-62762-2.Peer-Reviewed Original ResearchConceptsMitochondrial homeostasisTranscriptome analysisRegulation of mitochondrial homeostasisHost cell deathAnti-pathogen responsesCausative agentNuclear translocation assayAgent of Q feverBidirectional promoterNon-coding RNAsCausative agent of Q feverCo-regulationTranslocation assayCore setLncRNA researchLong non-coding RNAsCell deathPromoter assayMitochondrial dysfunctionIntracellular environmentSpatiotemporal mannerHost macrophagesRegulation of inflammationTHP-1 macrophagesAhR signalingMicrofluidic droplets with amended culture media cultivate a greater diversity of soil microorganisms
Dai J, Ouyang Y, Gupte R, Liu X, Li Y, Yang F, Chen S, Provin T, Van Schaik E, Samuel J, Jayaraman A, Zhou A, de Figueiredo P, Zhou J, Han A. Microfluidic droplets with amended culture media cultivate a greater diversity of soil microorganisms. Applied And Environmental Microbiology 2025, 91: e01794-24. PMID: 39936906, PMCID: PMC11921321, DOI: 10.1128/aem.01794-24.Peer-Reviewed Original ResearchConceptsSoil microorganismsSoil extractsSoil metabolitesMicroorganism diversityDiversity of soil microorganismsMicroorganism communitiesDownstream functional analysisSoil microorganism communitiesFunctional analysisMicrofluidic dropletsUnique generaUncultured microorganismsDiverse microorganismsNatural habitatsSoilIndividual isolatesCultivation conditionsClonal growthEnvironmental microorganismsHigh-throughput phenotypingBioremediationCulture media formulationsMicroorganismsCultivation methodsMedium formulation
2024
μREACT: A microfluidic system for rapid evaluation of trans-kingdom interactions
Huang C, Yang J, Chen S, Han S, Zhang H, Samuel J, Van Schaik E, de Figueiredo P, Han A. μREACT: A microfluidic system for rapid evaluation of trans-kingdom interactions. Biosensors And Bioelectronics 2024, 267: 116838. PMID: 39393191, DOI: 10.1016/j.bios.2024.116838.Peer-Reviewed Original ResearchTrans-kingdom interactionsInterkingdom interactionsHost cellsMammalian host cellsHost cell typesPhylogenetic spectrumBacterial speciesSpectrum of microorganismsBiological networksBiological processesEcosystem dynamicsSingle-cellCell typesDielectrophoretic separationHigh-throughputMicrobial samplesAdherent microorganismsFlow cytometry systemMicroorganismsMicrofluidic systemCellsHostEndosymbiosisInterkingdomCytometry systemMolecular mechanisms of Coxiella burnetii formalin-fixed cellular vaccine reactogenicity
Fratzke A, Szule J, Butler S, Schaik E, Samuel J. Molecular mechanisms of Coxiella burnetii formalin-fixed cellular vaccine reactogenicity. Infection And Immunity 2024, 92: e00335-24. PMID: 39356158, PMCID: PMC11556133, DOI: 10.1128/iai.00335-24.Peer-Reviewed Original ResearchCD4+ T cellsSmall cell variantWhole cell vaccineWeeks post-injectionSite of vaccinationT cellsCell variantPost-injectionAdoptive transfer experimentsLocal reactionsDelayed-type hypersensitivitySite of injectionCD8+Antigen persistenceCell vaccineQ-VaxCD4Mouse modelRod-shaped bacteriaHistological changesReactogenicityGuinea pigsVaccineCytokinesWeeksVaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria
van Schaik E, Fratzke A, Gregory A, Dumaine J, Samuel J. Vaccine development: obligate intracellular bacteria new tools, old pathogens: the current state of vaccines against obligate intracellular bacteria. Frontiers In Cellular And Infection Microbiology 2024, 14: 1282183. PMID: 38567021, PMCID: PMC10985213, DOI: 10.3389/fcimb.2024.1282183.Peer-Reviewed Original ResearchProtective immunityCD8+ T cell responsesEffective antibody-based vaccineT cell memory responsesImmune responseIntracellular bacteriaT cell responsesAntibody-based vaccinesObligate intracellular bacteriaNovel delivery platformCytotoxic CD8Chlamydia trachomatisMemory responsesHumoral responseSuccessful vaccinesAnimal modelsAntibody responseAntigen discoveryEfficacious vaccinesVaccine developmentEffective vaccineSARS-CoV-2CD8VaccineSARS-CoV-2 pandemic
1992
An experimental model for subclinical edema disease (Escherichia coli enterotoxemia) manifest as vascular necrosis in pigs.
Kausche F, Dean E, Arp L, Samuel J, Moon H. An experimental model for subclinical edema disease (Escherichia coli enterotoxemia) manifest as vascular necrosis in pigs. American Journal Of Veterinary Research 1992, 53: 281-7. PMID: 1595951, DOI: 10.2460/ajvr.1992.53.3.281.Peer-Reviewed Original ResearchConceptsEdema diseaseLesions of edema diseaseStrains of E coliWeanling pigsControl pigsNecropsy examinationClinical signsInoculationPigsNecrosis of myocytesNonpathogenic strainsTunica media of small arteriesVascular necrosisColony-forming unitsStrains of Escherichia coliMedia of small arteriesE coli strainsDaysE coliSegmental necrosisIleum