Jie Li
Financial Analyst 2, YSM FinanceCards
About
Research
Publications
2025
Prevalence and characteristics of off‐label use of antidepressants in paediatric patients in China
Zhang X, Li J, Zhang N, Liu T, Si T, Nie X, Shi L. Prevalence and characteristics of off‐label use of antidepressants in paediatric patients in China. General Psychiatry 2025, 38: e102229. PMID: 41439148, PMCID: PMC12719884, DOI: 10.1136/gpsych-2025-102229.Peer-Reviewed Original ResearchEfficacy and safety of GW117 tablets in major depressive disorder: a randomised, double‐blind, placebo‐controlled, phase 2 dose‐finding study
Shen Y, Hao X, Shi X, Tao Z, Yu X, Wang X, Di X, Yang H, Zhang Y, Li J, Wang Z, Zhang G, Wang J, Jiang Z, Wang R, Liu J, Dong Z, Gu W, Zhang H. Efficacy and safety of GW117 tablets in major depressive disorder: a randomised, double‐blind, placebo‐controlled, phase 2 dose‐finding study. General Psychiatry 2025, 38: e102337. PMID: 41425080, PMCID: PMC12716496, DOI: 10.1136/gpsych-2025-102337.Peer-Reviewed Original ResearchMajor depressive disorderTotal scoreAntidepressant efficacyDepressive disorderHAMD-17Montgomery-Asberg Depression Rating ScaleEvidence of antidepressant efficacyRating ScaleWeeks of double-blind treatmentMADRS total scoreDepression Rating ScaleHamilton Rating ScaleBaseline to week 8Double-blind treatmentWeek 8Dual-acting agentsMontgomery-AsbergHigh response ratePlacebo responseDepressive symptomsFixed doseGW117Post Hoc AnalysisMADRSPhase 2 dose-finding studyAssociation of triglyceride-glucose index with anxiety in first-episode, drug-naïve major depressive disorder: role of subclinical hypothyroidism
Tian X, Zhou Y, Qiu Y, Li M, Li J, Zhang X. Association of triglyceride-glucose index with anxiety in first-episode, drug-naïve major depressive disorder: role of subclinical hypothyroidism. European Archives Of Psychiatry And Clinical Neuroscience 2025, 1-10. PMID: 41359179, DOI: 10.1007/s00406-025-02158-x.Peer-Reviewed Original ResearchMajor depressive disorderMajor depressive disorder patientsAssociated with anxiety symptomsFEDN MDD patientsMDD patientsDepressive disorderAnxiety symptomsFirst-episodeSubclinical hypothyroidismAssociated with anxietyHigher anxiety scoresAnxiety severityHAMD-17Anxiety distressHAMA-14Insulin resistanceInteraction testAnxietyAnxiety scoresSubclinical hypothyroid statusAnxiety levelsConclusionsThe TyG indexFEDNMethodsThis cross-sectional studyCross-sectional studyPlasma biomarkers in drug-naïve schizophrenia with severe cognitive impairment via targeted metabolomics
Dong Y, Wang S, Qiu Y, Su Q, Sun X, Li M, Li J. Plasma biomarkers in drug-naïve schizophrenia with severe cognitive impairment via targeted metabolomics. Psychoneuroendocrinology 2025, 184: 107711. PMID: 41308587, DOI: 10.1016/j.psyneuen.2025.107711.Peer-Reviewed Original ResearchConceptsLiquid chromatography-mass spectrometryArea under the curveNon-SCI patientsSeverely cognitively impaired patientsSevere cognitive impairmentSymptoms of schizophreniaSZ patientsHealthy controlsCognitive impairmentEarly recognitionCore symptomsDiscovery setDrug-naive schizophreniaChromatography-mass spectrometryAssociated with social cognitionCore symptoms of schizophreniaGlycerophospholipid metabolismValidation setSocial cognitionPlasma biomarkersPatientsCognitive dysfunctionCognitive functionPlasma metabolitesSeverity assessmentNeural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity
Jing Y, Zhang M, Liu Y, Gao Y, Zhang B, Chen C, Xuekelaiti Z, Zhou Y, Zhang C, Li M, Li J. Neural mechanisms of suicide thoughts and behaviors in major depressive disorder: abnormal regional brain activity and its functional connectivity. BMC Psychiatry 2025, 25: 1040. PMID: 41168736, PMCID: PMC12574107, DOI: 10.1186/s12888-025-07483-y.Peer-Reviewed Original ResearchConceptsMajor depressive disorder patientsMajor depressive disorderRegional brain activityMiddle occipital gyrusFunctional connectivitySuicidal ideationSuicide attemptsNeural mechanismsBrain activityFC analysisMDD patientsDepressive disorderBrain regionsBeck Scale for Suicide IdeationSample of MDD patientsScale for Suicide IdeationRight inferior frontal gyrusDrug-naive MDD patientsSeed-based d mappingRight middle occipital gyrusAbnormal regional brain activityCognitive control regionsInferior frontal gyrusWhole-brain analysisLeft angular gyrusThe chain mediating role of social support and perceived stress on the relationship between depression severity and quality of life in patients with major depressive disorder
Zhang C, Tian X, Li M, Liu Y, Gao Y, Li J. The chain mediating role of social support and perceived stress on the relationship between depression severity and quality of life in patients with major depressive disorder. Journal Of Neural Transmission 2025, 1-10. PMID: 41099820, DOI: 10.1007/s00702-025-03037-4.Peer-Reviewed Original ResearchDepressive disorderHAMD-17Depression severitySocial Support Rating ScaleChain mediating rolePerceived stressSocial supportQOL-6PSS-10Hamilton Depression Rating Scale-17Quality of lifeImpact of depressive symptomsDebilitating mental illnessEffect of social supportDrug-naive patientsNegative impact of depressive symptomsDSM-5Depressive symptomsPerceived Stress Scale-10 itemPatient healthRating ScaleMental illnessMDDDepressionSocial interactionSuicide risk, psychopathology and cognitive impairments in schizophrenia with insomnia: a large-scale cross-sectional study
Lu C, Qi D, Ping Y, Zhang C, Wang S, Liu N, Wang X, Li S, Li J. Suicide risk, psychopathology and cognitive impairments in schizophrenia with insomnia: a large-scale cross-sectional study. BMC Psychiatry 2025, 25: 920. PMID: 41039393, PMCID: PMC12490073, DOI: 10.1186/s12888-025-07306-0.Peer-Reviewed Original ResearchConceptsSeverity of suicidal ideationChronic schizophrenia patientsPositive and Negative Syndrome ScaleSchizophrenia patientsPatient's psychiatric symptomsSuicide riskSuicidal ideationInsomnia Severity IndexLanguage functionCognitive impairmentPsychopathology scoresPsychiatric symptomsPredictors of suicide riskAssessment of Neuropsychological StatusAssociated with suicide riskNegative Syndrome ScalePrevalence of suicide riskHigh risk of suicideRisk of suicideLanguage function scoreSyndrome ScaleRepeatable BatteryNeuropsychological StatusBeck ScalePsychopathologyChildhood trauma combined with suicide attempts affects cognitive function and inflammation levels in drug-naive patients with major depressive disorder
Xie M, Liu Y, Jing Y, Gao Y, Liu Y, Li J, Mao F. Childhood trauma combined with suicide attempts affects cognitive function and inflammation levels in drug-naive patients with major depressive disorder. Psychoneuroendocrinology 2025, 182: 107611. PMID: 41016322, DOI: 10.1016/j.psyneuen.2025.107611.Peer-Reviewed Original ResearchConceptsRepeatable Battery for Assessment of Neuropsychological StatusMajor depressive disorder patientsMajor depressive disorderBeck Scale for Suicide Ideation-Chinese VersionRepeatable Battery for Assessment of Neuropsychological Status total scoresDrug-naive patientsChildhood Trauma QuestionnaireChildhood traumaSuicide attemptsDepressive disorderFirst-episode drug-naive patientsHealthy controlsTotal scoreCognitive impairmentAssessment of Neuropsychological StatusTNF-a levelsTumor necrosis factor receptor 2Associated with cognitive impairmentTNF-aEnzyme-linked immunosorbent assayImmediate memoryTrauma QuestionnaireNeuropsychological StatusAttention deficitCognitive domainsImpact of duration of untreated psychosis on early clinical outcomes in drug-naïve schizophrenia: A 12-week follow-up study
Sun X, Tian T, Jia Q, Wang J, Su Q, Qiu Y, Li M, Li J. Impact of duration of untreated psychosis on early clinical outcomes in drug-naïve schizophrenia: A 12-week follow-up study. Journal Of Psychiatric Research 2025, 190: 499-511. PMID: 40925164, DOI: 10.1016/j.jpsychires.2025.09.011.Peer-Reviewed Original ResearchConceptsDuration of untreated psychosisShort-DUP groupShorter duration of untreated psychosisSchizophrenia patientsUntreated psychosisDUP groupGlobal functioningImpact of duration of untreated psychosisEffects of duration of untreated psychosisLong duration of untreated psychosisAssociated with early treatment responseDrug-naive schizophrenia patientsNegative symptom scoresDrug-naive schizophreniaLong-DUP groupNegative symptom trajectoriesTreatment-resistant symptomsAntipsychotic doseNegative symptomsInteraction effectsSymptom trajectoriesSchizophreniaWeek 4 onwardsEarly treatment responseEarly treatment outcomesThe relationship between age of onset, peripheral plasma protein markers and social cognition in first-episode drug-naïve schizophrenia
Su Q, Liu Y, Ji L, Sun X, Feng Z, Xu Y, Zhou B, Qiu Y, Li M, Li J. The relationship between age of onset, peripheral plasma protein markers and social cognition in first-episode drug-naïve schizophrenia. Schizophrenia Research 2025, 285: 11-18. PMID: 40913934, DOI: 10.1016/j.schres.2025.08.019.Peer-Reviewed Original ResearchConceptsFirst-episode drug-naive schizophreniaMATRICS Consensus Cognitive BatteryAge-of-onsetDrug-naive schizophreniaSocial cognitionSCZ patientsLate-onset groupAssociated with social cognitionPlasma protein markersEnzyme-linked immunosorbent assayConsensus Cognitive BatterySocial cognitive performanceSchizophrenia patientsCognitive batteryCognitive performanceSchizophreniaMediation analysisPartial correlation analysisCognitionProtein markersExpression levelsKeratin 4HLA-DPB1Notch4 expressionPatients