Jie Li
Financial Analyst 2, YSM FinanceCards
About
Research
Publications
2025
Ufmylation Suppresses Unfolded Protein Response to Prevent Peripartum Cardiomyopathy
Tandra V, Zhang L, Lee C, Wu Y, Yue G, Li H, Su H, Li J. Ufmylation Suppresses Unfolded Protein Response to Prevent Peripartum Cardiomyopathy. JACC Basic To Translational Science 2025, 101293. PMID: 40742366, DOI: 10.1016/j.jacbts.2025.04.007.Peer-Reviewed Original ResearchUbiquitin-like protein modificationsExcessive endoplasmic reticulum stressUnfolded protein responsePeripartum cardiomyopathyMitochondrial oxidative metabolismEndoplasmic reticulum stressProtein responseLigase 1UfmylationProtein modificationTranscriptomic alterationsReticulum stressMTOR signalingPhysiological cardiac remodelingOxidative metabolismCardiac remodelingHeart failurePathological remodelingCardiomyopathyUfm1HeartRemodelingEnzymeHomeostasisMetabolismSex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia
Qin Q, Lu C, Li S, Liu N, Li Y, Li T, Dong Y, Wang X, Li S, Li J, Zhang X. Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia. European Archives Of Psychiatry And Clinical Neuroscience 2025, 1-10. PMID: 40397181, DOI: 10.1007/s00406-025-02020-0.Peer-Reviewed Original ResearchPositive and Negative Syndrome ScaleHamilton Depression ScaleHamilton Anxiety ScaleReduced P3 amplitudeHamilton Anxiety Scale scoresEvent-related potentialsSex differencesP3 amplitudeP3a latencyHealthy controlsN1 amplitudeAntipsychotic-naive schizophreniaGeneral psychopathology scoreNegative Syndrome ScaleHamilton Depression Scale scoresAuditory oddball paradigmSyndrome ScaleCompare sex differencesProlonged latencyPsychopathology scoresP3 componentN100 amplitudeAnxiety ScaleOddball paradigmCognitive impairmentThe dynamic role of ufmylation in endothelium
Lee C, Sibley J, Dai C, Li H, Su H, Li J. The dynamic role of ufmylation in endothelium. Physiology 2025, 40: 0746. DOI: 10.1152/physiol.2025.40.s1.0746.Peer-Reviewed Original ResearchUbiquitin-fold modifier 1Bulk RNA sequencingHuman umbilical vein endothelial cellsEndothelial cellsUbiquitin-like proteinDisrupt blood vessel formationCdh5-Cre miceAssociated with coronary artery diseaseVascular developmentCoronary artery diseaseProtein substratesRegulate vascular toneGene setsUFL1UfmylationExpressed genesBulk-RNAEnzymatic cascadeModifier 1Umbilical vein endothelial cellsCell cycleECKO miceCell homeostasisImpaired cell viabilityEndothelial cell homeostasisOTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development
Li Y, Zambrano-Carrasco J, Cui Y, Li J, Su H. OTUD6B Regulates Ventricular Chamber Maturation and Is Required for Mouse Embryonic Development. Physiology 2025, 40: 0884. DOI: 10.1152/physiol.2025.40.s1.0884.Peer-Reviewed Original ResearchVentricular septal defectVentricular chamber developmentCell cycle regulationCell cycle progressionCardiac defectsSeptal defectCycle regulationCycle progressionSignificant cardiac defectsVentricular chamber maturationDefective cell cycle progressionCongenital heart defectsRegulating protein stabilityAbnormal cell cycle progressionPostnatal day 1Regulating cardiomyocyte proliferationSevere cardiac phenotypeIncreased cardiac stiffnessS-phase arrestMouse embryonic developmentUnbiased transcriptome analysisMyocardial hypoplasiaHeart defectsFatty acid metabolismCardiac phenotypeRBX1-Cullin RING Ubiquitin Ligases Are Indispensable For Perinatal Cardiac Development Through Regulating The Hippo-YAP Signaling Pathway
Zambrano-Carrasco J, Jiao K, Li J, Su H. RBX1-Cullin RING Ubiquitin Ligases Are Indispensable For Perinatal Cardiac Development Through Regulating The Hippo-YAP Signaling Pathway. Physiology 2025, 40: 0183. DOI: 10.1152/physiol.2025.40.s1.0183.Peer-Reviewed Original ResearchCullin-RING ubiquitin E3 ligasesCullin proteinsCardiac morphologic abnormalitiesHippo-YAPCardiac morphogenesisCardiac developmentDosage-sensitive regulatorRING ubiquitin ligasesMulti-subunit complexesTranscriptional regulatory mechanismsUbiquitin E3 ligaseHippo-YAP signaling pathwayHippo-YAP pathwayRegulation of cardiac morphogenesisHeart failureDefective cardiac developmentExpression of genesMammalian heart developmentCardiomyocyte proliferationCell autonomous roleHypoplastic ventricular myocardiumVentricular chamber developmentAdaptor proteinCullin-RINGBiventricular non-compactionDeciphering the cardioprotective role of UFM1 modification in cardiac physiopathological remodeling
Tandra V, Ayala J, Gazik M, Sibley J, Singh N, Komatsu M, Li H, Su H, Li J. Deciphering the cardioprotective role of UFM1 modification in cardiac physiopathological remodeling. Physiology 2025, 40: 0743. DOI: 10.1152/physiol.2025.40.s1.0743.Peer-Reviewed Original ResearchCardiac remodelingUbiquitin-like protein modificationsCardiac proteinsLeft ventricleBeta-adrenergic agonist isoproterenolConjugation-deficient mutantsUb-like proteinsER stress responsePathological cardiac remodelingHypertrophic mouse heartsMonths of ageER homeostasisImpaired contractilityProtein substratesChamber dilationDilated CardiomyopathyAgonist isoproterenolCardiac contractilityCKO heartsCKO miceUfm1Heart failureUfmylationExacerbated fibrosisProtein modificationDifferential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder
Ping Y, Liu N, Li T, Lu C, Zeng M, Zhang X, Wang L, Liu J, Li S, Li J. Differential patterns of executive dysfunction across depressive phenotype in schizophrenia and major depressive disorder. Journal Of Neural Transmission 2025, 132: 1075-1084. PMID: 40289028, DOI: 10.1007/s00702-025-02929-9.Peer-Reviewed Original ResearchConceptsMajor depressive disorderMore-odd shifting taskNegative symptomsDepressive symptomsExecutive functionSZ patientsEF dysfunctionEF subdomainsDepressive disorderPsychopathological symptomsShift taskPositive and Negative Syndrome ScaleHealthy controlsPattern of executive dysfunctionMajor depressive disorder patientsNegative Syndrome ScaleStroop Color-WordHamilton Anxiety ScaleHamilton Depression ScaleMore-oddDifferential patternSyndrome ScaleColor wordsDepressive phenotypeEF performanceImmediate memory is associated with alexithymia in Chinese Han first-episode, drug-naïve major depressive disorder
Tian X, Bai F, Zhao Y, Gao Y, Wang Y, Liu Y, Zhang C, Li M, Li J. Immediate memory is associated with alexithymia in Chinese Han first-episode, drug-naïve major depressive disorder. Frontiers In Psychiatry 2025, 16: 1473204. PMID: 40206647, DOI: 10.3389/fpsyt.2025.1473204.Peer-Reviewed Original ResearchDepressive disorderImmediate memoryNeurocognitive functionFirst-episode drug-naive patientsAssociated with immediate memoryGeneralized Anxiety Disorder-7 itemsHigher levels of alexithymiaTAS total scoreMajor depressive disorderAssociated with alexithymiaToronto Alexithymia ScaleLevels of alexithymiaAssociated with lower scoresDrug-naive patientsPatient Health QuestionnaireFeelings facetRepeatable BatteryAlexithymia ScaleFirst-episodeTAS-20Assess alexithymiaCognitive deficitsAlexithymiaGAD-7MDDNeurophysiological Markers of Auditory Verbal Hallucinations in Patients with Schizophrenia: An EEG Microstates Study
Li S, Hu R, Yan H, Chu L, Qiu Y, Gao Y, Li M, Li J. Neurophysiological Markers of Auditory Verbal Hallucinations in Patients with Schizophrenia: An EEG Microstates Study. Brain Topography 2025, 38: 29. PMID: 39920494, DOI: 10.1007/s10548-025-01105-2.Peer-Reviewed Original ResearchConceptsAVH patientsAuditory verbal hallucinationsSchizophrenia patientsNon-AVH groupHallucinating patientsMicrostate BEEG microstatesNeurophysiological markersPotential neurophysiological markersMicrostate CSeverity of symptomsVerbal hallucinationsPatientsHigh-density electroencephalography dataTherapeutic interventionsSchizophreniaClass C microstatesSeverityDurationNegative correlationGroupHallucinationsSymptomsOlanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway
Li S, Fu Y, Wang W, Qiu J, Huang Y, Li X, Yang K, Yu X, Ma Y, Zhang Y, Zhang M, Li J, Li W. Olanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway. Current Neuropharmacology 2025, 23: 412-425. PMID: 39150031, PMCID: PMC12105311, DOI: 10.2174/1570159x22666240815120547.Peer-Reviewed Original ResearchAdministration of olanzapineTreated with olanzapineReactive oxygen speciesDownstream PI3K-Akt signal pathwayAssociated with obesityActive glycolysisAssessed body weightWeight gainDifferentiated 3T3-L1 preadipocytesLiver fat levelsPI3K-Akt pathwayOlanzapineDrug doseFemale miceDietary patternsMetabolic markersPI3K-AktFood intakeGlucose uptakeMouse modelGlycolipid abnormalitiesRodent modelsBody weightGAPDH expressionSignaling pathway