Huaigui Liu
Visiting Research ScientistAbout
Research
Publications
2026
Shared genetic underpinnings of gray matter volume alterations and metabolic traits in major depressive disorder
Wu X, Wang P, Lang X, Guo Q, Jiang Y, Xu J, Wang Q, Kang Y, Liu F, Ding H, Liu H. Shared genetic underpinnings of gray matter volume alterations and metabolic traits in major depressive disorder. BMC Psychiatry 2026 PMID: 41723432, DOI: 10.1186/s12888-026-07895-4.Peer-Reviewed Original ResearchGray matter volume alterationsGray matter volumeGenome-wide association studiesProtein-protein interactionsVoxel-based morphometryMetabolic traitsPleiotropic lociDepressive disorderConjunctional false discovery rateLeft superior temporal gyrusGray matter volume reductionTranscriptomic correlation analysisInferior frontal gyrusBackgroundMajor depressive disorderAllen Human Brain AtlasSuperior temporal gyrusGene Ontology enrichmentMulti-omics studiesHuman Brain AtlasConjFDR analysisFalse discovery rateNeurostructural deficitsAssociation studiesFrontal gyrusNeurostructural abnormalitiesNetwork localization of brain functional effects of ketamine treatment for major depression
Ma H, Liu H, Zhang W, Zhao X, Zhang D, An K, Qian Y, Zhu J. Network localization of brain functional effects of ketamine treatment for major depression. European Psychiatry 2026, 69: e28. PMID: 41684114, PMCID: PMC12978991, DOI: 10.1192/j.eurpsy.2026.10164.Peer-Reviewed Original ResearchConceptsEffects of ketamine treatmentKetamine treatmentNeurobiological effectsAntidepressant response to ketamineBrain functional alterationsResponse to ketamineEffects of ketamineFunctional MRI datasetsAntidepressant treatmentDepressed individualsDepressed patientsNeuroimaging correlatesTemporal poleBrain representationsBrain effectsPsychiatric therapeuticsApplication of ketamineHyper-functionBrain locationsKetamineFunctional alterationsBrainClinical applicationNetwork perspectiveDepressionMulti-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer’s Disease
Wang P, Wu X, Sun F, Zhang H, Jiang Y, Wang Q, Ding H, Zhou Y, Liu F, Liu H. Multi-omics integration reveals shared genetic architecture between metabolic markers and gray matter atrophy in Alzheimer’s Disease. The Journal Of Prevention Of Alzheimer's Disease 2026, 13: 100452. PMID: 41478820, PMCID: PMC12869038, DOI: 10.1016/j.tjpad.2025.100452.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenetic architectureFunctional enrichment analysisConjFDR analysisEnrichment analysisAlzheimer's diseaseAssociation analysisConjunctional false discovery rateGenome-wide association study summary statisticsMetabolic traitsFalse discovery rateTreatment of ADAssociation studiesLipid traitsGenetic basisProgressive neurodegenerative disorderConjFDRBiological insightsMolecular interplayAD pathophysiologyMeta-analysisGenesAllen Human Brain AtlasHDL-CBiological relevance
2025
Relapsing polychondritis with isolated tracheal involvement: Imaging findings on CT, MRI, and PET-CT: A case report and literature review
Jiang Y, Su Q, Zhao Y, Sun F, Wang P, Wu X, Yun J, Liu H. Relapsing polychondritis with isolated tracheal involvement: Imaging findings on CT, MRI, and PET-CT: A case report and literature review. Radiology Case Reports 2025, 20: 6075-6082. PMID: 41035746, PMCID: PMC12482309, DOI: 10.1016/j.radcr.2025.08.092.Peer-Reviewed Original ResearchC-reactive proteinRelapsing PolychondritisPET-CTInterleukin-6Progressive destructionLow-grade feverRare autoimmune disorderElevated inflammatory markersFollow-up imagingImmunosuppressive therapyNonproductive coughRespiratory involvementRecurrent inflammationTracheal involvementImaging findingsInflammatory markersCase reportAutoimmune disordersSore throatRheumatoid factorIrregular thickeningStudy CTDiagnostic approachPolychondritisLaboratory resultsIdentification of genetic architecture shared between schizophrenia and Alzheimer’s disease
Liu H, Xie Y, Ji Y, Zhou Y, Xu J, Tang J, Liu N, Ding H, Qin W, Liu F, Yu C. Identification of genetic architecture shared between schizophrenia and Alzheimer’s disease. Translational Psychiatry 2025, 15: 150. PMID: 40240757, PMCID: PMC12003746, DOI: 10.1038/s41398-025-03348-w.Peer-Reviewed Original ResearchConceptsPolygenic overlapFalse discovery rateGenetic architectureAlzheimer's diseaseConditional/conjunctional false discovery rateConditional false discovery rateGenome-wide association studiesIndividuals of European ancestryConcordant effect directionsGenetic risk architectureMolecular genetic mechanismsHeritable brain disorderAssociation studiesGenetic mechanismsGenetic variantsEuropean ancestryGenetic associationObserved comorbiditySchizophreniaSNPsDiscovery rateCognitive declineRisk architectureBrain disordersGenetic correlations
2024
Functional magnetic resonance imaging alternations in suicide attempts individuals and their association with gene expression
Jiang Y, Zhou Y, Xie Y, Zhou J, Cai M, Tang J, Liu F, Ma J, Liu H. Functional magnetic resonance imaging alternations in suicide attempts individuals and their association with gene expression. NeuroImage Clinical 2024, 43: 103645. PMID: 39059208, PMCID: PMC11326948, DOI: 10.1016/j.nicl.2024.103645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDepressive disorderSpontaneous brain activityBipolar disorderBrain activityFunctional magnetic resonance imaging abnormalitiesFunctional magnetic resonance imaging changesHistory of attempted suicideVoxel-based meta-analysisBilateral inferior temporal gyrusInferior frontal gyrusPatterns of spontaneous brain activityAllen Human Brain AtlasInferior temporal gyrusBrain activity alterationsBilateral paracentral lobuleHistory of SAHuman Brain AtlasIncreased spontaneous brain activationFrontal gyrusFusiform gyrusRight insulaNeurobiological basisTemporal gyrusEarly developmental periodShared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes
Xie Y, Zhao Y, Zhou Y, Jiang Y, Zhang Y, Du J, Cai M, Fu J, Liu H. Shared Genetic Architecture Among Gastrointestinal Diseases, Schizophrenia, and Brain Subcortical Volumes. Schizophrenia Bulletin 2024, 50: 1243-1254. PMID: 38973257, PMCID: PMC11349026, DOI: 10.1093/schbul/sbae099.Peer-Reviewed Original ResearchConceptsLocal genetic correlationProtein-protein interactionsPolygenic overlapGenetic architectureBrain subcortical volumesGenome-wide association study dataSubcortical volumesProtein-protein interaction analysisCell-type enrichmentGenetic correlationsFunctional annotationGut-brain axisHub genesGenetic mechanismsGenetic variantsColocalization analysisBiological processesImmune systemData of schizophreniaGenesDevelopment of interventionsSchizophreniaGastrointestinal diseasesTherapy targetGI diseasesVoxel-based texture similarity networks reveal individual variability and correlate with biological ontologies
Lin L, Chang Z, Zhang Y, Xue K, Xie Y, Wei L, Li X, Zhao Z, Luo Y, Dong H, Liang M, Liu H, Yu C, Qin W, Ding H. Voxel-based texture similarity networks reveal individual variability and correlate with biological ontologies. NeuroImage 2024, 297: 120688. PMID: 38878916, DOI: 10.1016/j.neuroimage.2024.120688.Peer-Reviewed Original ResearchConceptsTest-retest reliabilityCovariance networksSouthwest University Adult Lifespan DatasetStructural magnetic resonance imagingStructural covariance networksStructural covariance patternsDorsal neocortexIndividual variabilitySimilarity networkHuman Connectome ProjectBrain regionsBrain processesBehavioral varianceLifespan datasetsSex differencesBiological substratesConnection strengthConnectome ProjectTopological propertiesCovariance patternsHuman brainNetwork topological propertiesIndividual structural covariance networksMagnetic resonance imagingNeocortexSelective disrupted gray matter volume covariance of amygdala subregions in schizophrenia
Chang Z, Liu L, Lin L, Wang G, Zhang C, Tian H, Liu W, Wang L, Zhang B, Ren J, Zhang Y, Xie Y, Du X, Wei X, Wei L, Luo Y, Dong H, Li X, Zhao Z, Liang M, Zhang C, Wang X, Yu C, Qin W, Liu H. Selective disrupted gray matter volume covariance of amygdala subregions in schizophrenia. Frontiers In Psychiatry 2024, 15: 1349989. PMID: 38742128, PMCID: PMC11090100, DOI: 10.3389/fpsyt.2024.1349989.Peer-Reviewed Original ResearchGray matter volume covarianceGray matter volumeAnterior amygdaloid areaAmygdala subregionsSchizophrenia patientsNegative Symptom ScaleVoxel-wise general linear modelHealthy controlsDuration of illnessOrbitofrontal cortexMatter volumeRight BASchizophreniaAmygdalaSymptom ScaleConnectivity patternsSubregionsSample size of patientsSize of patientsFunctional abnormalitiesCorrelation analysisStriatumGeneralized linear modelPatientsHippocampusExploring functional dysconnectivity in schizophrenia: alterations in eigenvector centrality mapping and insights into related genes from transcriptional profiles
Ji Y, Cai M, Zhou Y, Ma J, Zhang Y, Zhang Z, Zhao J, Wang Y, Jiang Y, Zhai Y, Xu J, Lei M, Xu Q, Liu H, Liu F. Exploring functional dysconnectivity in schizophrenia: alterations in eigenvector centrality mapping and insights into related genes from transcriptional profiles. Schizophrenia 2024, 10: 37. PMID: 38491019, PMCID: PMC10943118, DOI: 10.1038/s41537-024-00457-1.Peer-Reviewed Original ResearchEigenvector centrality mappingFunctional dysconnectivityNeural processesResting-state functional magnetic resonance imaging dataFunctional magnetic resonance imaging dataMiddle temporal gyrusCentral mapMagnetic resonance imaging dataMental health disordersTemporal gyrusBrain regionsSchizophreniaFunctional connectivityDysconnectivityBilateral thalamusPotential genetic factorsGenetic factorsHealthy adult brainHealth disordersHealthy controlsAdult brainSynaptic signalingInvestigate alterationsDisordersReplication stage