George Aghajanian, MD
Professor Emeritus of PsychiatryDownloadHi-Res Photo
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Professor Emeritus of Psychiatry
Departments & Organizations
- Abraham Ribicoff Research Facilities
- Connecticut Mental Health Center
Education & Training
- MD
- Yale University (1958)
- Resident
- Yale University
- Fellow
- Yale University
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Overview
Medical Research Interests
Hallucinogens; Neuropharmacology; Neurophysiology; Psychiatry
Research at a Glance
Publications Timeline
A big-picture view of George Aghajanian's research output by year.
6Publications
973Citations
Publications
2009
Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices
Aghajanian GK. Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices. Psychopharmacology 2009, 206: 575-585. PMID: 19241062, PMCID: PMC2755104, DOI: 10.1007/s00213-009-1484-9.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAberrant network activityBrain slicesReceptor agonistPyramidal cellsLayer V pyramidal cellsRecent phase II clinical trialPhase II clinical trialGABAA receptor antagonismStandard antipsychotic drugsMGlu2/3 receptor agonistGlutamatergic pyramidal cellsNetwork activityCortical brain slicesDopamine receptor agonistsTreatment of schizophreniaUsual side effectsPrefrontal brain slicesNeuronal network activityInterneuron deficitsGABA interneuronsClinical efficacyLysergic acid diethylamideMetabotropic receptorsReceptor antagonismClinical endpoints
2008
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 359-364. PMID: 18172209, PMCID: PMC2224217, DOI: 10.1073/pnas.0706679105.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsExcitatory postsynaptic currentsLayer V pyramidal neuronsMedial prefrontal cortexApical dendritic atrophyDendritic atrophyPyramidal neuronsRestraint stressPrefrontal cortexGlucocorticoid receptor antagonist RU486Apical dendritic fieldReceptor antagonist RU486Mild restraint stressWhole-cell recordingsMPFC slicesChronic treatmentStress-induced reductionExcitatory responsesSpine densityApical dendritesPostsynaptic currentsDendritic fieldsExcitatory inputsPyramidal cellsAntagonist RU486Selective atrophy
1973
DOPAMINERGIC NEURONS: SIMILAR BIOCHEMICAL AND HISTOCHEMICAL EFFECTS OF γ-HYDROXYBUTYRATE AND ACUTE LESIONS OF THE NIGRONEOSTRIATAL PATHWAY
WALTERS J, ROTH R, AGHAJANIAN G. DOPAMINERGIC NEURONS: SIMILAR BIOCHEMICAL AND HISTOCHEMICAL EFFECTS OF γ-HYDROXYBUTYRATE AND ACUTE LESIONS OF THE NIGRONEOSTRIATAL PATHWAY. Journal Of Pharmacology And Experimental Therapeutics 1973, 186: 630-639. PMID: 4728341, DOI: 10.1016/s0022-3565(25)29634-3.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsDA pathwayInhibition of impulse flowElectrothermic lesionsNigro-neostriatal pathwayDA-containing cellsBrain monoaminesNeostriatal dopamineDA levelsBehavioral effectsNeostriatal DAImpulse flowGBL treatmentBrain levelsGBL administrationNigroneostriatal pathwayDA fluorescenceSubstantia nigraDopamineExtracellular recording experimentsBrainSites of increaseAnesthetic doseGHBG-butyrolactoneRecording experiments
1972
SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE
KUHAR M, ROTH R, AGHAJANIAN G. SYNAPTOSOMES FROM FOREBRAINS OF RATS WITH MIDBRAIN RAPHE LESIONS: SELECTIVE REDUCTION OF SEROTONIN UPTAKE. Journal Of Pharmacology And Experimental Therapeutics 1972, 181: 36-45. PMID: 4552069, DOI: 10.1016/s0022-3565(25)29173-x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsConcentrations of 5-HTRaphe lesionsSynaptosomal uptakeUptake of 3H-5-HTTricyclic agent imipramineMidbrain raphe lesionsNerve endingsMidbrain raphe nucleiTryptophan hydroxylase activityTime coursePlacement of lesionsRaphe nucleusSerotonin uptakeRaphe neuronsLesioned animalsUptake activityMidbrain areaL-norepinephrineLesionsHydroxylase activityRapheIncubation mediumForebrainL-tryptophanAnimals
1968
STIMULATION OF THE MIDBRAIN RAPHE: EFFECT ON SEROTONIN METABOLISM
SHEAUD M, AGHAJANIAN G. STIMULATION OF THE MIDBRAIN RAPHE: EFFECT ON SEROTONIN METABOLISM. Journal Of Pharmacology And Experimental Therapeutics 1968, 163: 425-430. PMID: 4878661, DOI: 10.1016/s0022-3565(25)28089-2.Peer-Reviewed Original ResearchCitationsMeSH Keywords and Concepts
1967
ELECTRON-MICROSCOPIC LOCALIZATION OF TRITIATED NOREPINEPHRINE IN RAT BRAIN: EFFECT OF DRUGS
Aghajanian G, Bloom F. ELECTRON-MICROSCOPIC LOCALIZATION OF TRITIATED NOREPINEPHRINE IN RAT BRAIN: EFFECT OF DRUGS. Journal Of Pharmacology And Experimental Therapeutics 1967, 156: 407-416. PMID: 6027453, DOI: 10.1016/s0022-3565(25)27643-1.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsNerve endingsIntraventricular injectionCerebral ventricular systemCellular localizationEffects of drugsDrug-pretreatedDense-core vesiclesVentricular routeReserpine treatmentCaudate nucleusDistribution of autoradiographic grainsVentricular systemBehavioral recoveryReserpineNerveAutoradiographic grainsElectron microscopic autoradiographyPattern of localizationHypothalamus
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