Erik Zorrilla, PhD
Postdoctoral AssociateAbout
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Postdoctoral Associate
Biography
Dr. Erik Zorrilla is a Postdoctoral Associate in the Department of Neurology at Yale University School of Medicine and a member of the Yale Center for the Science of Cannabis and Cannabinoids (YC-SCAN2).
He earned his PhD in Neuroscience at The University of Iowa under Dr. Andrew F. Russo. The focus of his doctoral research was to investigate the effects of cannabinoids on central and peripheral mechanisms underlying migraine pathophysiology. Importantly, findings from this work helped secure a grant to support a clinical trial for a cannabinoid-based migraine medication in collaboration with Delphian Therapeutics.
At Yale, he is conducting clinical research under the mentorship of Dr. Emanuelle A. D. Schindler and Dr. Deepak C. D’Souza. His research interests seek to understand how cannabinoids and psychedelics may serve as novel therapeutic approaches for neurological and psychiatric disorders. Outside of research he enjoys traveling, and training Brazilian Jiu jitsu.
Appointments
Education & Training
- PhD
- The University of Iowa, Neuroscience (2024)
- BS
- Upper Iowa University, Biology (2018)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-1666-9959
Publications
2025
Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice
Zorrilla E, Duong TL, Piña CL, Russo AF. Cannabinoids rescue migraine symptoms caused by central CGRP administration in mice. Cephalalgia 2025, 45: 03331024251392103. DOI: 10.1177/03331024251392103.Peer-Reviewed Original ResearchCombined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice
Zorrilla E, Krivoshein G, Kuburas A, Schenke M, Piña CL, van Heiningen SH, Waite JS, Dehghani A, Castonguay WC, Flinn HC, van den Maagdenberg AM, Russo AF, Tolner EA, Wattiez AS. Combined effects of cannabidiol and Δ9-tetrahydrocannabinol alleviate migraine-like symptoms in mice. Cephalalgia 2025, 45: 03331024251314487. DOI: 10.1177/03331024251314487.Peer-Reviewed Original Research
2024
Interplay between cannabinoids and the neuroimmune system in migraine
Zorrilla E, Della Pietra A, Russo AF. Interplay between cannabinoids and the neuroimmune system in migraine. The Journal Of Headache And Pain 2024, 25: 178. DOI: 10.1186/s10194-024-01883-3.Peer-Reviewed Original Research
2021
CGRP induces migraine-like symptoms in mice during both the active and inactive phases
Wattiez AS, Gaul OJ, Kuburas A, Zorrilla E, Waite JS, Mason BN, Castonguay WC, Wang M, Robertson BR, Russo AF. CGRP induces migraine-like symptoms in mice during both the active and inactive phases. The Journal Of Headache And Pain 2021, 22: 62. DOI: 10.1186/s10194-021-01277-9.Peer-Reviewed Original Research
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