Dibyadeep Datta

Dr. Datta is a neuroscientist dedicated to elucidating the neurobiological mechanisms underlying cognitive dysfunction in major neuropsychiatric and neurodegenerative disorders, with a particular focus on schizophrenia and Alzheimer’s disease. His research focuses on understanding how cellular, molecular, and circuit-level perturbations contribute to the pathogenesis of cognitive deficits, with the overarching goal of dissecting etiological mechanisms and identifying novel therapeutic targets.

Dr. Datta’s research integrates multidisciplinary approaches—including molecular neurobiology, anatomy, multi-OMICS platforms, systems neuroscience, and translational models—to delineate the vulnerability of higher-order cortical circuits essential for working memory, executive function, and goal-directed behavior. A central theme of this research is the characterization of synaptic and circuit impairments in association cortices, particularly in the dorsolateral prefrontal cortex and medial temporal lobe, which are selectively affected in schizophrenia and Alzheimer’s disease.

By probing the etiological drivers of disease pathogenesis, such as genetic risk variants, neuroinflammatory signaling, calcium dysregulation, and tau and amyloid pathology, Dr. Datta seeks to establish mechanistic links between molecular disruptions and functional circuit outcomes. His work also emphasizes the development and evaluation of targeted intervention strategies, including pharmacological modulation and circuit-level therapies, aimed at restoring cognitive function in affected individuals.

Through this research, Dr. Datta aspires to bridge basic neuroscience with clinical translation, contributing to a deeper understanding of disease mechanisms and advancing therapeutic innovation for disorders marked by profound cognitive impairment.