Dionisios Sakkas, PhD
About
Education & Training
- PhD
- Monash University (1990)
Research
Research at a Glance
Publications Timeline
A big-picture view of Dionisios Sakkas's research output by year.
24Publications
420Citations
Publications
2024
The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes
Sakkas D, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Frantz N, Kopcow L, Andrade G, Ozturk B, Rienzi L, Weiser A, Valbuena D, Simón C, Rubio C. The impact of implementing a non-invasive preimplantation genetic testing for aneuploidies (niPGT-A) embryo culture protocol on embryo viability and clinical outcomes. Human Reproduction 2024, deae156. PMID: 39059790, DOI: 10.1093/humrep/deae156.Peer-Reviewed Original ResearchAltmetricConceptsNon-invasive preimplantation genetic testingEmbryo culture protocolsNiPGT-ADay of biopsyPreimplantation genetic testingPGT-APregnancy outcomesPregnancy rateIVF clinicsClinical outcomesControl groupStudy groupGenetic testingReproductive outcomesConcordance rateDay 6Clinical pregnancy rateOverall pregnancy outcomeClinical reproductive outcomesBiopsy stepBlastocyst mediumBlastocyst viabilityBlastocyst developmentCulture protocolMiscarriage rateP-060 When is it the sperm’s fault? The incidence of sperm-related poor fertilization after ICSI in 13,859 matched oocyte donation cycles
Torra M, Miguel-Escalada I, Rodriguez A, Popovic M, Morse B, Sakkas D. P-060 When is it the sperm’s fault? The incidence of sperm-related poor fertilization after ICSI in 13,859 matched oocyte donation cycles. Human Reproduction 2024, 39: deae108.437. DOI: 10.1093/humrep/deae108.437.Peer-Reviewed Original ResearchConceptsOocyte donation cyclesFertility outcomesSevere male factorMale factorOvarian stimulationFertilization rateICSI cyclesDonation cyclesDonor oocytesMale-related factorsOocyte donation modelComplete fertilization failurePoor fertility outcomesSperm-related factorsOrdinary least squares regressionRecipient cyclesLow fertilitySibling oocytesMale-relatedOocyte donationFertility diagnosticsOocyte vitrificationOocyte donorsPoor fertilityLong-term implicationsP-371 It’s worth the freeze: outcomes from thawing electively cryopreserved oocytes are comparable in patients with reduced vs normal ovarian reserve at the time of cryopreservation
Resetkova N, Hillis N, Duvall D, Sakkas D. P-371 It’s worth the freeze: outcomes from thawing electively cryopreserved oocytes are comparable in patients with reduced vs normal ovarian reserve at the time of cryopreservation. Human Reproduction 2024, 39: deae108.727. DOI: 10.1093/humrep/deae108.727.Peer-Reviewed Original ResearchConceptsNormal ovarian reserveElectively cryopreserved oocytesOocyte cryopreservation cyclesLive birth rateOvarian reserveOocyte yieldPregnancy success rateCryopreservation cyclesOocyte survivalAMH levelsAMH groupAcademically affiliated fertility centerAssessed prior to initiationCumulative live birth rateBirth rateFertilization rateBlastocyst conversion rateOocyte thawing cyclesOvarian reserve markersTime of cryopreservationCompromise ovarian reserveSuccess rateEmbryo developmentDevelopmental milestonesOocyte thawP-543 Multicenter concordance study of embryo cell-free DNA and trophectoderm biopsies: impact on clinical outcomes
Sánchez L, Sakkas D, Frantz N, Soscia D, Venier B, Bisioli C, DiMattina M, Ozturk B, Barroso G, Escudero E, De la Fuente E, Valbuena D, Simon C, Rubio C. P-543 Multicenter concordance study of embryo cell-free DNA and trophectoderm biopsies: impact on clinical outcomes. Human Reproduction 2024, 39: deae108.882. DOI: 10.1093/humrep/deae108.882.Peer-Reviewed Original ResearchConceptsSingle embryo transferTE biopsy resultsCell-free DNATrophectoderm biopsyMiscarriage rateBiopsy resultsClinical outcomesChi-square testNon-invasive preimplantation genetic testingFrozen single embryo transferInner cell mass biopsiesStatistical significanceCell-free DNA analysisDecrease miscarriage ratesPGT-A cyclesPreimplantation genetic testingDroplet of culture mediumLocal institutional review boardAssisted reproduction centerBiopsied blastocystsNiPGT-ATE biopsyEuploid embryosBlastocyst biopsyBlastocyst mediumP-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A
LLuesa C, Navarro-Sánchez L, Ardestani G, Barroso G, Bisioli C, Boynukalin K, Cimadomo D, Andrade G, Valbuena D, Simon-Valles C, Sakkas D. P-533 Impact on clinical outcomes of day-6 extended culture and reduced culture media volume applied to non-invasive PGT-A. Human Reproduction 2024, 39: deae108.873. DOI: 10.1093/humrep/deae108.873.Peer-Reviewed Original ResearchConceptsNon-invasive PGT-ACell-free DNAPGT-ASingle embryo transferClinical outcomesDay 5Pregnancy rateStudy groupNiPGT-AConcordance ratePregnancy outcomesDay 6Control groupCell-free DNA resultsDay 5 blastocystsDay 6 blastocystsClinical pregnancy rateDay of biopsyOverall pregnancy outcomeEmbryo culture protocolsBiopsy stepPGT-A.Euploidy rateBlastocyst viabilityBlastocyst qualityIDENTIFYING A TARGET NUMBER OF RETRIEVED OOCYTES TO COMPLETE FAMILY BUILDING FROM A SINGLE IVF CYCLE
Huttler A, Duvall D, Alper M, Sakkas D, Vaughan D. IDENTIFYING A TARGET NUMBER OF RETRIEVED OOCYTES TO COMPLETE FAMILY BUILDING FROM A SINGLE IVF CYCLE. Fertility And Sterility 2024, 122: e35-e36. DOI: 10.1016/j.fertnstert.2024.05.063.Peer-Reviewed Original ResearchHISTORY OF PRIOR TERMINATION DOES NOT NEGATIVELY IMPACT IVF SUCCESS RATES
Martinez S, Macharia A, Sakkas D, Duvall D, Vaughan D. HISTORY OF PRIOR TERMINATION DOES NOT NEGATIVELY IMPACT IVF SUCCESS RATES. Fertility And Sterility 2024, 122: e50. DOI: 10.1016/j.fertnstert.2024.05.090.Peer-Reviewed Original ResearchPerinatal outcomes are similar in programmed and modified natural frozen embryo transfer cycles
Farrell A, Yuen M, Dodge L, Sakkas D, Vaughan D, Toth T. Perinatal outcomes are similar in programmed and modified natural frozen embryo transfer cycles. Reproductive BioMedicine Online 2024, 104347. DOI: 10.1016/j.rbmo.2024.104347.Peer-Reviewed Original ResearchAltmetricConceptsFrozen embryo transfer cyclesEmbryo transfer cyclesIschemic placental diseasePreterm deliveryPerinatal outcomesPlacental diseaseTransfer cyclesIncreased risk of cesarean deliveryRisk of ischemic placental diseaseIncreased riskRisk of cesarean deliveryNatural FET cyclesIntrauterine growth restrictionNeonatal clinical outcomesModified natural cycleRetrospective cohort studyMode of deliveryCesarean deliverySGA infantsGestational ageFET cyclesGrowth restrictionClinical outcomesCohort studyPatientsCulture time to optimize embryo cell-free DNA (cfDNA) analysis for frozen-thawed blastocysts undergoing non-invasive preimplantation genetic testing for aneuploidy (niPGT-A)
Ardestani G, Banti M, García-Pascual C, Navarro-Sánchez L, Van Zyl E, Castellón J, Simón C, Sakkas D, Rubio C. Culture time to optimize embryo cell-free DNA (cfDNA) analysis for frozen-thawed blastocysts undergoing non-invasive preimplantation genetic testing for aneuploidy (niPGT-A). Fertility And Sterility 2024 PMID: 38718960, DOI: 10.1016/j.fertnstert.2024.04.037.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFrozen-thawed blastocystsCell-free DNANon-invasive preimplantation genetic testingPreimplantation genetic testingNiPGT-ADay 5Concordance rateDay 6Genetic testingExpansion gradeBlastocyst expansion gradeNext generation sequencingSpent mediumWhole genome amplificationBlastocyst DNABlastocyst mediumPGT-ANo significant differenceGrade 3BlastocystSignificant differenceGenome amplificationAneuploidyIdeal timeCompare timeEffect of time post warming to embryo transfer on human blastocyst metabolism and pregnancy outcome
Ardestani G, Martins M, Ocali O, Sanchez T, Gulliford C, Barrett C, Sakkas D. Effect of time post warming to embryo transfer on human blastocyst metabolism and pregnancy outcome. Journal Of Assisted Reproduction And Genetics 2024, 41: 1539-1547. PMID: 38642271, PMCID: PMC11224190, DOI: 10.1007/s10815-024-03115-8.Peer-Reviewed Original ResearchAltmetricConceptsFrozen embryo transferLive birth rateEmbryo transferPregnancy outcomesBlastocyst metabolismPGT-ABirth rateNon-PGT cyclesPost-warming cultureNon-invasive metabolic imagingResultsThe mean ageRetrospective cohort studyMinimal metabolic changesHuman blastocystsMiscarriage rateMean ageCohort studyPost-warmingBlastocystMetabolic imagingMetabolic perturbationsPregnancyPatient treatmentClinical practicePatient cases