Christina Paraggio
About
Research
Publications
2025
SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes
Dastpak M, Mimoso C, Farshchian M, Paraggio C, Leonard C, Yin S, Chi B, Nassar K, Rowe R, Zhang J, Hou Z, Daley G, Adelman K, Reed R. SF3B1K700E mutation in human embryonic stem cells causes aberrant expression of immune-related genes. PLOS ONE 2025, 20: e0334361. PMID: 41406100, PMCID: PMC12711085, DOI: 10.1371/journal.pone.0334361.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsPrecision run-on sequencingPre-mRNA splicing factorsGene expressionHeterozygous substitutionEmbryonic stem cellsRNA Pol IIPre-spliceosome assemblyMyelodysplastic syndromeHematologic malignanciesCell typesExpression of immune-related genesAberrant expressionPRO-seqPre-spliceosomePause releaseImmune gene expressionPol IIU2 snRNPStem cellsTranscription elongationMutations of SF3B1Splicing factorsCandidate genesMutator phenotype
2023
Causal ALS genes impact the MHC class II antigen presentation pathway
Chi B, Öztürk M, Paraggio C, Leonard C, Sanita M, Dastpak M, O’Connell J, Coady J, Zhang J, Gygi S, Lopez-Gonzalez R, Yin S, Reed R. Causal ALS genes impact the MHC class II antigen presentation pathway. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2305756120. PMID: 37722062, PMCID: PMC10523463, DOI: 10.1073/pnas.2305756120.Peer-Reviewed Original ResearchConceptsHematopoietic progenitor cellsAmyotrophic lateral sclerosisStem cellsMHC class II antigen presentation pathwayClass II antigen presentation pathwayMHC-II expressionHuman embryonic stem cellsTranscription factor CIITAAmyotrophic lateral sclerosis genesAntigen presentation pathwayC9orf72-ALS patientsPluripotent stem cellsMHC-II heterodimersALS-associated proteinsRNA/DNA-binding proteinMajor histocompatibility complexMHC II pathwayHLA-DREmbryonic stem cellsHuman microglial cellsImmune cellsExpression of genesProgenitor cellsII expressionPresentation pathway
2022
Measurement invariance of a household water insecurity metric in Greater Accra, Ghana: Implications for test-retest reliability
Sidote M, Goodman Z, Paraggio C, Tutu R, Stoler J. Measurement invariance of a household water insecurity metric in Greater Accra, Ghana: Implications for test-retest reliability. International Journal Of Hygiene And Environmental Health 2022, 240: 113922. PMID: 35026673, DOI: 10.1016/j.ijheh.2022.113922.Peer-Reviewed Original ResearchConceptsHousehold Water Insecurity ExperiencesHousehold water insecurityWater insecuritySurvey wavesGlobal poverty alleviationAnti-poverty programsPeri-urban communitiesMeasures of well-beingPoverty alleviationGreater AccraHouseholdsUnobserved factorsDiverse contextsWell-beingInsecurityGhanaAccraHousehold water useSurvey