Burhan Ozturk, MD
Clinical FellowCards
About
Research
Publications
2023
Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport
Ozturk B, Koundal S, Al Bizri E, Chen X, Gursky Z, Dai F, Lim A, Heerdt P, Kipnis J, Tannenbaum A, Lee H, Benveniste H. Continuous positive airway pressure (CPAP) increases CSF flow and glymphatic transport. JCI Insight 2023, 8: e170270. PMID: 37159262, PMCID: PMC10371231, DOI: 10.1172/jci.insight.170270.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressurePositive airway pressureGlymphatic transportAirway pressureIntracranial pressureEnd-expiratory lung volumeCSF bulk flowCerebrospinal fluid flowArterial oxygenationUpper airwayLung volumeCPAP deviceRespiratory functionClearance functionTherapeutic benefitSkull baseAnesthetized rodentsCSF flowFluid homeostasisPhysiological testingLymphatic systemFunctional crosstalkClinical devicesAirwayRats
2022
Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling
Lee H, Ozturk B, Stringer MS, Koundal S, MacIntosh BJ, Rothman D, Benveniste H. Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling. NeuroImage 2022, 261: 119512. PMID: 35882269, PMCID: PMC9969358, DOI: 10.1016/j.neuroimage.2022.119512.Peer-Reviewed Original ResearchConceptsWater flowBlood perfusionLow-dose isofluraneCerebral blood flowClinical translational studiesAnti-diuretic hormoneContinuous arterial spinLevels of bloodMeasurement accuracyMagnetic resonance imagingArterial spin labelingCerebrospinal fluid productionAnesthetic regimensBalanced anesthesiaCerebral ventricleContinuous arterial spin labelingIsoflurane anesthesiaKey parametersSystemic administrationVentricular CSFImmune surveillanceArterial bloodBlood flowTissue perfusionChoroid plexus
2021
Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics
Ozturk BO, Monte B, Koundal S, Dai F, Benveniste H, Lee H. Disparate volumetric fluid shifts across cerebral tissue compartments with two different anesthetics. Fluids And Barriers Of The CNS 2021, 18: 1. PMID: 33407650, PMCID: PMC7788828, DOI: 10.1186/s12987-020-00236-x.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingApparent diffusion coefficientCerebrospinal fluidGlymphatic transportSprague-Dawley female ratsLow-dose isofluraneCrossover study designRepetitive magnetic resonance imagingDawley female ratsTissue compartmentsVolume statusAnesthesia groupBasal cisternsDiffusion-weighted imagesDexmFemale ratsParenchymal expansionHeart rateGlymphatic systemDifferent anestheticsIsofluraneTissue statusResonance imagingFluid shiftsCSF compartment
2020
Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
Benveniste H, Lee H, Ozturk B, Chen X, Koundal S, Vaska P, Tannenbaum A, Volkow ND. Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging. Neuroscience 2020, 474: 63-79. PMID: 33248153, PMCID: PMC8149482, DOI: 10.1016/j.neuroscience.2020.11.014.Peer-Reviewed Original Research