Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsAmanda Kallen, MD
Associate Professor AdjunctAbout
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Titles
Associate Professor Adjunct
Biography
Dr. Amanda N. Kallen is Associate Professor of Obstetrics and Gynecology at the Yale School of Medicine and a member of the Reproductive Scientist Development Program (RSDP). She obtained her medical degree at the University of Connecticut and completed her Residency in Obstetrics and Gynecology at Yale-New Haven Hospital, followed by a fellowship in Reproductive Endocrinology and Infertility at the Yale School of Medicine. During her fellowship, she was accepted into the RSDP scholar program, an NIH-funded physician-scientist training program committed to training young obstetrician-gynecologists in biomedical science. Upon completion of her fellowship, she was recruited to join the Yale Division of Reproductive Endocrinology and Infertility.
Dr. Kallen has published in leading scientific journals, and her current research program is focused on the investigation of the regulation of gene expression in granulosa cells. Her clinical interests include pediatric and adolescent gynecology and endocrinology, infertility, and premature ovarian insufficiency. She is the recipient of multiple awards for teaching, clinical excellence, and research, including the Yale University "Resident of Excellence" award, the North American Menopause Society / Teva Medical Resident Excellence Award, the American Society of Reproductive Medicine (ASRM) Resident Reporter award, the Association of Professors of Gynecology and Obstetrics Resident Scholar award.
Dr. Kallen is highly active with the American Congress of Obstetricians and Gynecologists (ACOG), currently serving on the Executive Board as the national Junior Fellow Congress Advisory Council Chair. She is also a graduate of ACOG's Robert Cefalo Leadership Institute. Additionally, she plays an active role in medical student and resident education and serves as a faculty mentor for the Yale medical student Ob/Gyn Interest Group. Lastly, she serves as an Interactive Associate for Fertility & Sterility and a reviewer for multiple journals, and is a member of the ASRM Women's Council.
Departments & Organizations
- Center for RNA Science and Medicine
- Fertility Preservation Program
- In Vitro Fertilization Program
- Kallen Lab
- Recurrent Pregnancy Loss Program
Education & Training
- Fellow in Reproductive Endocrinology & Infertility
- Yale School of Medicine (2014)
- Administrative Chief Resident
- Yale-New Haven Hospital (2011)
- Resident
- Yale-New Haven Hospital (2010)
- MD
- University of Connecticut School of Medicine (2007)
Research
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Overview
Medical Research Interests
ORCID
0000-0003-0118-3251
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Hugh Taylor, MD
Emre Seli, MD
Lingeng Lu, MD, PhD
David Seifer, MD
Hai Feng Zhang
Shannon Whirledge, PhD, MSc
MicroRNAs
RNA, Long Noncoding
Ovary
Granulosa Cells
Infertility
Publications
2025
Undermining Women’s Health Research — Gambling with the Public’s Health
Kallen A, Whirledge S, Goldman K, Johnson J. Undermining Women’s Health Research — Gambling with the Public’s Health. New England Journal Of Medicine 2025, 392: 2185-2187. PMID: 40435490, DOI: 10.1056/nejmp2503576.Peer-Reviewed Original ResearchCitationsAltmetricReply of the authors: adding to the evolving landscape of fertility preservation research
Mercier A, Johnson J, Kallen A. Reply of the authors: adding to the evolving landscape of fertility preservation research. Fertility And Sterility 2025, 124: 172. PMID: 40311995, DOI: 10.1016/j.fertnstert.2025.04.031.Peer-Reviewed Original ResearchCorrigendum to ‘Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure’ [Fertility and Sterility 122 (2024) 565-573]
Mercier A, Johnson J, Kallen A. Corrigendum to ‘Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure’ [Fertility and Sterility 122 (2024) 565-573]. Fertility And Sterility 2025, 123: 744. PMID: 40047740, DOI: 10.1016/j.fertnstert.2024.12.021.Peer-Reviewed Original ResearchCitations
2024
Evidence-based guideline: Premature Ovarian Insufficiency † ‡
ESHRE A, Yeganeh L, Giri R, Flanagan M, Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. Evidence-based guideline: Premature Ovarian Insufficiency † ‡. Fertility And Sterility 2024, 123: 221-236. PMID: 39652037, DOI: 10.1016/j.fertnstert.2024.11.007.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHealth care professionalsCentre for Research ExcellencePremature ovarian insufficiencyProvision of careGuideline development groupCare professionalsRandomised controlled trialsDiagnosis of premature ovarian insufficiencyAnti-Mullerian hormoneBritish Menopause SocietyData Safety Monitoring BoardHormone therapyInternational Menopause SocietyBayer PharmaScoping surveyAmerican Society for Reproductive MedicineWomen's healthConsulting feesMenopause SocietyReproductive Scientist Development ProgramAdvisory BoardOvarian insufficiencyAttending meetingsClinical questionsSurvey of womenEvidence-based guideline: premature ovarian insufficiency†‡
ASRM C, Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. Evidence-based guideline: premature ovarian insufficiency†‡. Climacteric 2024, 27: 510-520. PMID: 39647506, DOI: 10.1080/13697137.2024.2423213.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProvision of careGuideline development groupAnti-Mullerian hormoneFollicle stimulating hormoneHealthcare professionalsHormone therapyScoping surveyClinical questionsSurvey of womenElevated follicle stimulating hormoneFollicle stimulating hormone measurementsEuropean Society of Human Reproduction and Embryology (ESHREDevelopment groupQuality of lifeRandomized Controlled TrialsCombined oral contraceptivesPractice careGeneral well-beingAnti-Mullerian hormone testCognitive healthIntegrative reviewNon-hormonal treatmentsESHRE Executive CommitteeWomen's healthMuscle healthEvidence-based guideline: premature ovarian insufficiency,
Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Mousa A, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A, Yeganeh L, Giri R, Flanagan M. Evidence-based guideline: premature ovarian insufficiency,. Human Reproduction Open 2024, 2024: hoae065. PMID: 39660328, PMCID: PMC11631070, DOI: 10.1093/hropen/hoae065.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHealth care professionalsClinical practice guidelinesCentre for Research ExcellencePremature ovarian insufficiencyProvision of careGuideline development groupCare professionalsDiagnosis of premature ovarian insufficiencyAnti-Mullerian hormoneAmerican Society for Reproductive MedicineBritish Menopause SocietyData Safety Monitoring BoardRandomized Controlled TrialsPractice guidelinesInternational Menopause SocietyHormone therapyScoping surveyBayer PharmaWomen's healthConsulting feesMenopause SocietyReproductive Scientist Development ProgramAdvisory BoardOvarian insufficiencyAttending meetingsSENESCENT CELL CLEARANCE PROTECTS THE OVARIAN RESERVE IN AGING MICE
Zhang J, Lopez J, Liang J, Sela M, Kallen A. SENESCENT CELL CLEARANCE PROTECTS THE OVARIAN RESERVE IN AGING MICE. Fertility And Sterility 2024, 122: e21. DOI: 10.1016/j.fertnstert.2024.07.121.Peer-Reviewed Original ResearchProspective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure
Mercier A, Johnson J, Kallen A. Prospective solutions to ovarian reserve damage during the ovarian tissue cryopreservation and transplantation procedure. Fertility And Sterility 2024, 122: 565-573. PMID: 39181229, DOI: 10.1016/j.fertnstert.2024.08.330.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOvarian tissue cryopreservationPrimordial follicle growth activationOvarian reserve damageTissue cryopreservationLoss of primordial folliclesThawing protocolRestoration of ovarian functionTransplantation techniquesAmerican Society for Reproductive MedicineSusceptible to ischemic reperfusion injuryIschemic reperfusion injuryEfficacy of adjuvantsAssisted Reproductive TechnologyOvarian cortexPrimordial folliclesGonadotoxic treatmentOvarian reserveAdjuvant treatmentImmature folliclesLive birthsOvarian functionOvarian tissueSlow-freezing approachReperfusion injuryTransplant proceduresO-111 Premature ovarian insufficiency: new data and updated guidance
Panay N, Anderson R, Bennie A, Cedars M, Davies M, Ee C, Gravholt C, Kalantaridou S, Kallen A, Kim K, Misrahi M, Nappi R, Rocca W, Ruan X, Teede H, Vermeulen N, Vogt E, Vincent A. O-111 Premature ovarian insufficiency: new data and updated guidance. Human Reproduction 2024, 39: deae108.122. DOI: 10.1093/humrep/deae108.122.Peer-Reviewed Original ResearchCitationsConceptsPremature ovarian insufficiencyAmerican Society for Reproductive MedicineEvidence-based recommendationsOvarian insufficiencyInternational Menopause SocietyDiagnosis of premature ovarian insufficiencyIatrogenic premature ovarian insufficiencyManagement of premature ovarian insufficiencyClinical questionsNon-hormonal treatmentsHormone therapyFertility preservationTreatment optionsClinical managementMenopause SocietyGuideline groupDevastating conditionEuropean guidelinesHormone treatmentClinical guidanceSexual functionReproductive medicineMusculoskeletal healthMuscle healthWomen's health
2023
hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study
Wesevich V, Seckin S, Kelk D, Kallen A, Kodaman P. hMG addition affects the change in progesterone level during IVF stimulation and LBR: a retrospective cohort study. Reproductive Biology And Endocrinology 2023, 21: 117. PMID: 38057813, PMCID: PMC10699021, DOI: 10.1186/s12958-023-01150-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsClinical pregnancy rateFresh embryo transferPeak P levelsPregnancy outcomesEmbryo transferPregnancy rateIVF stimulationCohort studyHigher clinical pregnancy rateOvarian hyperstimulation IVFSingle fertility centerMethodsRetrospective cohort studyRetrospective cohort studyClinical pregnancy outcomesDay of triggerFrozen embryo transferMultivariable logistic modelLower pregnancy ratesP riseEndometrial receptivityProvider recommendationFertility centerProgesterone levelsConclusionsOur dataHigher LBR