Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsJonathan Alexander, MD
Assistant Clinical ProfessorAbout
Research
Publications
2025
Calcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches
Delgadillo L, Rashdan N, Hamilton H, Pattillo J, Yuan S, Eshaq R, Harris N, Alexander J, Pattillo C. Calcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches. Pathophysiology 2025, 32: 66. PMID: 41441180, PMCID: PMC12736360, DOI: 10.3390/pathophysiology32040066.Peer-Reviewed Original ResearchVascular smooth muscle cellsGCL modifier subunitSmooth muscle cellsVascular calcificationGlutamate-cysteine ligaseCoronary artery vascular smooth muscle cellsHuman coronary artery vascular smooth muscle cellsMuscle cellsArtery vascular smooth muscle cellsPredictor of cardiovascular morbidityMurine vascular smooth muscle cellsVascular smooth muscle cell calcificationKEGG pathway analysisLoss of contractile phenotypeRegulating vascular smooth muscle cellOxidative stressImpaired contractionCardiovascular morbidityTherapeutic approachesOsteogenic transdifferentiationGlutamate-cysteine ligase modifier subunitContractile phenotypeEnzyme glutamate-cysteine ligasePhosphate-rich mediumPhenotypic switchingEnteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration
Colvin J, O’Quin C, Meyer H, Welch V, Solitro G, Alexander J, Sorrells D. Enteric Elongation Induced by a Novel Sleeve Device in a Live Roux-en-Y Configuration. Bioengineering 2025, 12: 771. PMID: 40722463, PMCID: PMC12292125, DOI: 10.3390/bioengineering12070771.Peer-Reviewed Original ResearchShort bowel syndromeRoux limb lengthRoux-en-YLong-term parenteral nutritionRoux-en-Y configurationDelayed gastric emptyingCurrent surgical optionsParenteral nutritionSurgical optionsIntestinal dilatationGastric emptyingBowel syndromeIntestinal lengtheningTissue remodelingRoux limbSleeve deviceWeeks post-deploymentBowelRatsLimb lengthWeeks4. Effect of GLP-2 Coated Vaginal Expansion Sleeves (VES) in a Rat Model
Colvin J, Cline R, Meyer H, Sorrells D, Alexander J, Shah-Bruce M. 4. Effect of GLP-2 Coated Vaginal Expansion Sleeves (VES) in a Rat Model. Journal Of Pediatric And Adolescent Gynecology 2025, 38: 221. DOI: 10.1016/j.jpag.2025.01.016.Peer-Reviewed Original ResearchVaginal lengthVaginal canalGLP-2Average vaginal lengthMild to moderate inflammationMinimally invasive alternativeGlucagon-like peptide 2Resin capVaginal atresiaRat vaginaDilation therapySurgical vaginoplastyLymphoid infiltratesCongenital absenceInvasive alternativeCanal lengthModerate inflammationProcedural interventionRat modelFemale reproductive tissuesCurrent treatmentNon-intestinal tissuesNonabsorbable suturesMuscular layerRats
2024
Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices.
Colvin J, Sorrells D, Alexander J. Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices. Journal Of Visualized Experiments 2024 PMID: 39671324, DOI: 10.3791/67358.Peer-Reviewed Original ResearchPathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI)
White L, Conrad S, Alexander J. Pathophysiology and Prevention of Manual-Ventilation-Induced Lung Injury (MVILI). Pathophysiology 2024, 31: 583-595. PMID: 39449524, PMCID: PMC11503381, DOI: 10.3390/pathophysiology31040042.Peer-Reviewed Original ResearchManual ventilationLung injuryManual hyperventilationOperator-dependent skillsShort-term ventilationMechanism of injuryManikin-based studyBag valve maskAmerican Heart AssociationEuropean Resuscitation CouncilHyperventilated patientsMechanical ventilationHemodynamic alterationsHealthcare providersHeart AssociationPatient populationResuscitation effortsGastric regurgitationResuscitation CouncilCardiopulmonary resuscitationVentilation parametersPatientsInjury processAcute barotraumaVentilationImpaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient
Yilmaz G, Alexander J. Impaired Peripheral Vascular Function Following Ischemic Stroke in Mice: Potential Insights into Blood Pressure Variations in the Post-Stroke Patient. Pathophysiology 2024, 31: 488-501. PMID: 39311310, PMCID: PMC11417821, DOI: 10.3390/pathophysiology31030036.Peer-Reviewed Original ResearchIncreased blood pressure variabilityBlood pressure variabilityIschemic strokeAcetylcholine-induced endothelium-dependent vasodilationAssociated with poor clinical outcomesEndothelium-dependent vasodilator responsesPeripheral arteriesVascular smooth muscle toneResponse to SNPStroke animalsImpaired peripheral vascular functionPhenylephrine-induced vasoconstrictionEndothelium-dependent vasodilationPoor clinical outcomesSmooth muscle toneThoracic aortic segmentsDeterminants of blood pressurePressure variabilityPeripheral vascular functionPeripheral vascular responseWire myographyIsolated aortaVasoconstrictor responsesVasodilator responseRemote arterySTABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes
Morgan K, Morris J, Cai Q, Kilgore P, Cvek U, Trutschl M, Lofton K, Mavuram M, Ramesh P, Dao N, Alhaque A, Alexander J. STABILITY (Symptomatic Review during Biologic Therapy) of Inflammatory Bowel Disease Patients Receiving Infusion Therapy Improves Clinical Outcomes. Pathophysiology 2024, 31: 398-407. PMID: 39189166, PMCID: PMC11348379, DOI: 10.3390/pathophysiology31030030.Peer-Reviewed Original ResearchInflammatory bowel disease patientsInflammatory bowel diseaseFemale IBD patientsMale CD patientsMale IBD patientsCD patientsUC patientsTherapy visitsIBD patientsDisease severityInfusion therapyFemale UC patientsMale UC patientsRetrospective chart reviewIBD-related symptomsPhysician-patient contactLow disease activityPhysician-patient interviewImprove patient outcomesFemale CD patientsCare gapsImproving clinical outcomesDiagnosis dateMedication changesChronic diseasesInhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome
Alexander J, Vazquez-Ramirez L, Lin C, Antonoudiou P, Maguire J, Wagner F, Jacob M. Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome. EMBO Molecular Medicine 2024, 16: 2109-2131. PMID: 39103699, PMCID: PMC11393422, DOI: 10.1038/s44321-024-00110-5.Peer-Reviewed Original ResearchHeterozygous loss-of-function variantsLoss-of-function variantsWnt signal transductionWnt target gene expressionSynaptic adhesion complexesTarget gene expressionB-cateninCognitive phenotypesHeterozygous mouse linePreclinical mouse modelsWild-type littermatesBrain functionAdhesion complexesSignal transductionEfficacious treatmentNeuronal functional propertiesRegulation of changesGene expressionMotor deficitsHeterozygous miceN-cadherinNa/K-ATPaseBrainMotor disabilityMouse modelDistraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome
O’Quin C, Clayton S, Trosclair L, Meyer H, Dao N, Minagar A, White L, Welch V, Solitro G, Alexander J, Sorrells D. Distraction Enterogenesis in Rats: A Novel Approach for the Treatment of Short Bowel Syndrome. Pathophysiology 2024, 31: 388-397. PMID: 39189165, PMCID: PMC11348226, DOI: 10.3390/pathophysiology31030029.Peer-Reviewed Original ResearchTreatment of short bowel syndromeIn vivo rat studyRat intestinal modelShort bowel syndromeSprague Dawley ratsSmall intestineParenteral nutritionBowel histologyBowel lengthDawley ratsLength-tension relationshipMucosal erosionsRat small intestineRat studiesBowel syndromeEx vivoRatsBowel tissueFailure loadPost-deploymentPatientsBowelHistologyLoad test dataIntestinal modelHistologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model
Meyer H, Trosclair L, Clayton S, O’Quin C, Crochet C, Colvin J, Welch V, Alhaque A, Solitro G, Shah-Bruce M, Alexander J, Sorrells D. Histologic Analysis of ‘Distraction Vaginogenesis’ in a Rat Model. Pathophysiology 2024, 31: 298-308. PMID: 38921727, PMCID: PMC11206798, DOI: 10.3390/pathophysiology31020022.Peer-Reviewed Original ResearchVaginal agenesisStained with hematoxylin and eosin (H&ERat vaginal tissueSprague Dawley ratsLocal immune reactionHematoxylin and eosin (H&EParaffin-embedded tissuesMasson's trichrome stainingAnti-desmin antibodiesMullerian agenesisResin capEosin (H&EVaginal tissueSurgical vaginoplastyVaginal canalDesmin immunostainingCanal lengthSubmucosal eosinophiliaMechanical dilatationNeutrophilic inflammationPost-surgicalDawley ratsChronic inflammationRat modelTrichrome staining