James Cross
About
Research
Publications
2026
26-A-17429-ACC ANGIOTENSIN II TYPE 1 RECEPTOR AUTOANTIBODIES IN IMMUNE CHECKPOINT INHIBITOR MYOCARDITIS: ASSOCIATION WITH MYOCARDIAL SCAR AND RESISTANCE TO IMMUNOSUPPRESSION
Tysarowski M, Crowdis J, Lin D, Cross J, Im Y, Miller M, Bow L, Kwan J. 26-A-17429-ACC ANGIOTENSIN II TYPE 1 RECEPTOR AUTOANTIBODIES IN IMMUNE CHECKPOINT INHIBITOR MYOCARDITIS: ASSOCIATION WITH MYOCARDIAL SCAR AND RESISTANCE TO IMMUNOSUPPRESSION. Journal Of The American College Of Cardiology 2026, 87: a1114-a1115. DOI: 10.1016/j.jacc.2026.02.2733.Peer-Reviewed Original ResearchCapitolunate arthrodesis versus four-corner fusion for advanced wrist collapse: a systematic review and meta-analysis
Al-Badaineh M, Shi R, Cross J, Jahagirdar O, Slevin J, Mekhail J, Luo X, Salameh M. Capitolunate arthrodesis versus four-corner fusion for advanced wrist collapse: a systematic review and meta-analysis. Journal Of Orthopaedic Surgery And Research 2026, 21: 268. PMID: 41821055, PMCID: PMC13097632, DOI: 10.1186/s13018-026-06747-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPatient-Rated Wrist EvaluationRange of motionVisual analog scaleFour-corner fusionPatient-rated outcome measuresScaphoid nonunion advanced collapseComplication profileFull-text reviewScreening of titlesReoperation rateScapholunate advanced collapseStandardized mean differenceRandomized Controlled TrialsSubgroup-specific analysesVisual analog scale scoreRetrospective cohort studyMotion-preserving techniqueWeb of Science databasesWrist EvaluationGrip strengthAdvanced collapseOutcome measuresCohort studyDASH scoreSystematic review
2025
Outcomes of reverse total shoulder arthroplasty vs. other surgical fixation methods for proximal humerus fractures in elderly patients
Mekhail J, Mullan R, Cross J, Jahagirdar O, Luo X, Salameh M. Outcomes of reverse total shoulder arthroplasty vs. other surgical fixation methods for proximal humerus fractures in elderly patients. JSES Reviews Reports And Techniques 2025, 6: 100644. PMID: 41685347, PMCID: PMC12890702, DOI: 10.1016/j.xrrt.2025.100644.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsThis study investigates surgical treatments for elderly patients with shoulder fractures, showing reverse shoulder arthroplasty improves function and lowers revision rates compared to alternatives.Risk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm
Levine A, Klug T, Cross J, Salameh M, Riedel M, Leslie M. Risk factors for cut-throughs in intertrochanteric hip fracture fixation Tip-Apex Distance (TAD) <10 mm and Apex-to-Center <4 mm. Injury 2025, 56: 112205. PMID: 39954635, DOI: 10.1016/j.injury.2025.112205.Peer-Reviewed Original ResearchConceptsTip-apex distanceIntertrochanteric hip fracturesHip fractureRisk factorsAnterior-posteriorLevel 1 academic trauma centerSliding hip screwFracture reduction qualityNeck-shaft angleCut-out complicationsTrauma centerHip screwNeck-shaftIntramedullary nailingRetrospective reviewReduction qualityReduced riskIncreased riskFracture typeClinical outcomesRiskComplicationsCohortLateral viewFixation devices
2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingBias in medical AI: Implications for clinical decision-making
Cross J, Choma M, Onofrey J. Bias in medical AI: Implications for clinical decision-making. PLOS Digital Health 2024, 3: e0000651. PMID: 39509461, PMCID: PMC11542778, DOI: 10.1371/journal.pdig.0000651.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMedical AIArtificial intelligenceClinical decision-makingSupervised learning modelsMedical artificial intelligenceDiverse data setsSocial determinants of healthDeployment solutionDeterminants of healthAI algorithmsData featuresDebiasing methodsPerformance metricsLearning modelsAI lifecycleAI developmentModel interpretationData setsSuboptimal performanceModel's clinical utilityHealthcare disparitiesSocial determinantsCare practicesDecision-makingImplicit cognitive biases
2022
Utilization of Machine Learning to Model Important Features of 30-day Readmissions following Surgery for Metastatic Spinal Column Tumors: The Influence of Frailty
Elsamadicy A, Koo A, Reeves B, Cross J, Hersh A, Hengartner A, Karhade A, Pennington Z, Akinduro O, Lo S, Gokaslan Z, Shin J, Mendel E, Sciubba D. Utilization of Machine Learning to Model Important Features of 30-day Readmissions following Surgery for Metastatic Spinal Column Tumors: The Influence of Frailty. Global Spine Journal 2022, 14: 1227-1237. PMID: 36318478, PMCID: PMC11289550, DOI: 10.1177/21925682221138053.Peer-Reviewed Original ResearchHospital Frailty Risk ScoreSpinal column tumorsFrailty Risk ScoreInfluence of frailtySpinal column metastasesProportion of patientsRetrospective cohort studyNationwide Readmissions DatabaseRisk of readmissionMultivariate regression analysisIntermediate frailtyAdult patientsCohort studyIndependent predictorsSurgical interventionSpine surgeryReadmissionPatient readmissionRisk scorePatientsFrailtySurgeryCohortTumorsRegression analysis
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