Voluntary Faculty
Voluntary faculty are typically clinicians or others who are employed outside of the School but make significant contributions to department programs at the medical center or at affiliate institutions.
Voluntary rank detailsHong Lin, MD
Assistant Clinical ProfessorAbout
Research
Publications
2026
Anxiety in male psoriasis mouse model is mediated by the interaction between γδ T cell-derived IL-17A and microglia
Yang J, Zhang S, Fu C, Dai Y, Sun Y, Dou X, Lin Y, Wu Y. Anxiety in male psoriasis mouse model is mediated by the interaction between γδ T cell-derived IL-17A and microglia. Neuropharmacology 2026, 290: 110908. PMID: 41780818, DOI: 10.1016/j.neuropharm.2026.110908.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorPsoriasis mouse modelBlood-brain barrierIL-17AImpaired BBB integrityT cellsMouse modelCD86+BBB integrityElevated plus maze testMicroglial activationMicroglial activation patternTight junction protein expressionIL-17A neutralizationLight-dark box testIMQ-treated micePlus maze testBlood-brain barrier integrityDepletion of microgliaJunction protein expressionEvans blue injectionMale C57BL/6J miceOpen field testInflammatory cytokine expressionOccludin expressionComparison of total intravenous anesthesia and combined inhalation and intravenous anesthesia on survival after tumor surgery: a propensity score matched cohort study
Wang Y, Wu X, Pei S, Chu Y, Yang Y, Lin Y, Ba D, Yin P, Wang J, Yao S. Comparison of total intravenous anesthesia and combined inhalation and intravenous anesthesia on survival after tumor surgery: a propensity score matched cohort study. Frontiers In Medicine 2026, 13: 1659919. PMID: 41756380, PMCID: PMC12932620, DOI: 10.3389/fmed.2026.1659919.Peer-Reviewed Original ResearchLong-term mortalityCox regression modelsPropensity score matched cohortPropensity score matchingTotal intravenous anesthesiaShort-term mortalityCancer surgery patientsCancer surgerySurgery patientsIntravenous anesthesiaRisk of 3-year mortalityCohort studyHazard ratioMultivariate Cox regression modelRisk of tumor metastasisAssociated with long-term mortalityEffect of anesthetic techniqueRetrospective cohort studyPropensity score-matched cohort studyScore-matched cohort studyTertiary care hospitalConfidence intervalsMatched Cohort StudyRegression modelsGeneral anesthesia technique
2025
Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced pulmonary endothelial barrier dysfunction by activating TXNDC5
Wang Y, Chen P, Huang S, Chen L, Ge Y, Gu H, Chu Y, Yang Y, Lin Y, Yao S. Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced pulmonary endothelial barrier dysfunction by activating TXNDC5. Journal Of Advanced Research 2025 PMID: 41456650, DOI: 10.1016/j.jare.2025.12.039.Peer-Reviewed Original ResearchPulmonary endothelial barrierIntegrated discrimination improvementNet reclassification improvementIncremental predictive valueThioredoxin domain-containing protein 5Pulmonary endothelial barrier dysfunctionLung ischemia-reperfusion injuryEndothelial cellsPulmonary endothelial cellsEndothelial barrier dysfunctionIschemia-reperfusion injuryER stressHuman umbilical vein endothelial cellsNF-kB activationUmbilical vein endothelial cellsFatal complicationEndoplasmic reticulum stressMajor surgeryNomogram modelVein endothelial cellsBarrier dysfunctionAAV-shRNAEndothelial functionSingle-cell RNA sequencingEndothelial integrityExercise and the organ-brain axis: Regulation of neurological disorders by emerging exerkines
Dai Y, Dou X, Nie B, Sun Y, Chen P, Fu C, Zhang X, Chu Y, Gao Q, Ge Y, Lin Y. Exercise and the organ-brain axis: Regulation of neurological disorders by emerging exerkines. Pharmacological Research 2025, 219: 107913. PMID: 40818821, DOI: 10.1016/j.phrs.2025.107913.Peer-Reviewed Original ResearchConceptsBlood-brain barrierCentral nervous systemBrain disordersCerebral energy metabolismImmune homeostasisPeripheral organsSynaptic plasticityFunctional alterationsNervous systemAdipose tissueNeuroprotective effectsMicroglia phenotypePeptide releaseMyokine secretionSkeletal muscleBrain homeostasisNeurological disordersDisordersRegulatory effectsBrainBrain functionSignaling moleculesEnergy metabolismHomeostasisAdaptive responseThe 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial
Sun S, Yin Q, Shen J, Lv Y, Li L, Mao Z, Lin Y, Chen X, Yang D. The 90% minimum effective volume and concentration of lidocaine for ultrasound-guided stellate ganglion blocks in adults: a biased-coin design, up-and-down sequential allocation trial. Korean Journal Of Anesthesiology 2025, 78: 471-481. PMID: 40590088, PMCID: PMC12489579, DOI: 10.4097/kja.24607.Peer-Reviewed Original ResearchIdentification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation
Sun S, Ding Y, Yang D, Shen J, Zhang T, Song G, Chen X, Lin Y, Chen R. Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation. Frontiers In Medicine 2025, 12: 1502189. PMID: 40166075, PMCID: PMC11955678, DOI: 10.3389/fmed.2025.1502189.Peer-Reviewed Original ResearchHub genesSeptic kidney injuryAcute kidney injurySignaling pathwayDrug-gene interaction databaseKidney injuryAssociated with hub genesGene Ontology biological processesProtein-protein interactionsIntensive care unitPotential hub genesDrug-gene interactionsCandidate genesKEGG pathwaysCytoscape softwareDrug-geneSTRING databaseInfiltration of immune cellsBioinformatics analysisGene screeningSerum creatinine levelsInteraction databasesRelated genesBiological processesGenes
2024
Real-world individual and comparative analysis of adverse event reporting for adalimumab and etanercept using public FDA adverse event reporting system data
Dou X, Dai Y, Zhu L, Lin Y, Wu Y. Real-world individual and comparative analysis of adverse event reporting for adalimumab and etanercept using public FDA adverse event reporting system data. Archives Of Dermatological Research 2024, 317: 161. PMID: 39738670, DOI: 10.1007/s00403-024-03626-5.Peer-Reviewed Original ResearchMaresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway
Dai M, Sun S, Dai Y, Dou X, Yang J, Chen X, Yang D, Lin Y. Maresin-1 Ameliorates Sepsis-Induced Microglial Activation Through Modulation of the P38 MAPK Pathway. Neurochemical Research 2024, 50: 26. PMID: 39565476, DOI: 10.1007/s11064-024-04280-z.Peer-Reviewed Original ResearchConceptsSepsis-induced neuroinflammationM1-type microgliaPro-inflammatory markersPhosphorylation of p38 MAPKP38 MAPK pathwayP38 MAPKDysregulated immune response to infectionMouse cecum ligationImmune response to infectionExpression of pro-inflammatory markersInhibited phosphorylation of p38 MAPKInduce neuronal degenerationMAPK pathwayPuncture (CLP)-induced sepsis modelPotential therapeutic roleP38 MAPK inhibitor SB203580Combination of SB203580Response to infectionMicroglial cell markersLife-threatening diseaseMAPK inhibitor SB203580Co-administrationCell markersCLP modelCecum ligationTreadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway
Ge Y, Dou X, Chen P, Chen J, Dai M, Yao S, Lin Y. Treadmill Exercise Enhances Post-Stroke Functional Recovery in Mice via the CX3CL1/CX3CR1 Signaling Pathway. Molecular Neurobiology 2024, 62: 591-603. PMID: 38886327, DOI: 10.1007/s12035-024-04287-1.Peer-Reviewed Original ResearchTreadmill exercisePost-strokeMorris water mazeTreadmill sessionsExercise mimeticsPost-stroke functional recoveryPost-ischemic strokePost-stroke recoveryTreadmillDentate gyrusRostral migratory streamEvaluate cognitive functionExerciseMiddle cerebral artery occlusionEnhanced neurogenesisCognitive functionModified neurological severity scoreSubventricular zoneSeverity scoreIschemic strokeSensorimotor functionControl groupFunctional recoveryExperimental groupIntraperitoneal injection of bromodeoxyuridineDiaphragm ultrasonography as a monitor in assessing antagonistic effect of sugammadex on rocuronium in patients with Child-Pugh grades A and B
Sun Y, Sun S, Chen R, Shen J, Chen X, Lin Y, Yao S. Diaphragm ultrasonography as a monitor in assessing antagonistic effect of sugammadex on rocuronium in patients with Child-Pugh grades A and B. Frontiers In Medicine 2024, 11: 1370021. PMID: 38686365, PMCID: PMC11057376, DOI: 10.3389/fmed.2024.1370021.Peer-Reviewed Original ResearchPreoperative Child-Pugh classificationEffects of sugammadexChild-Pugh classificationPost-anesthesia care unitThickening fractionDiaphragmatic ultrasonographyPost-surgeryChild-Pugh A groupLaparoscopic liver resection surgeryReversal effect of sugammadexChild-Pugh grade ACare unitNon-randomized controlled clinical trialChild-Pugh B groupBaseline diaphragm thicknessChild-Pugh gradeLiver resection surgeryDeep neuromuscular blockadeTrain-of-four ratioDiaphragm ultrasoundDiaphragm ultrasonographyDouble-blindNo significant differenceResection surgeryRocuronium-induced blockade
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