2018
Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age
Kuban K, Heeren T, O'Shea T, Joseph R, Fichorova R, Douglass L, Jara H, Frazier J, Hirtz D, Taylor H, Rollins J, Paneth N, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K, Yamamoto H, Ryan S, Junaid D, Dawood H, Beatty N, Luu N, Tang V, Sassi R, Pasicznyk J. Among Children Born Extremely Preterm a Higher Level of Circulating Neurotrophins Is Associated with Lower Risk of Cognitive Impairment at School Age. The Journal Of Pediatrics 2018, 201: 40-48.e4. PMID: 30029870, PMCID: PMC6684153, DOI: 10.1016/j.jpeds.2018.05.021.Peer-Reviewed Original ResearchConceptsWeeks of lifeNeurotrophic proteinsSevere cognitive impairmentBlood levelsCognitive impairmentInflammatory proteinLower riskBrain-derived neurotrophic factorNeonatal blood specimensProtein blood levelsHigh blood levelsAdverse cognitive outcomesElevated blood levelsLow Gestational Age Newborn StudyNormal T cellsYears of ageHigh exposureFunction testsNeurotrophic factorCognitive function levelT cellsReduced riskMultinomial logistic regressionElevated proteinBlood specimens
2017
Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm
Hirschberger R, Kuban K, O'Shea T, Joseph R, Heeren T, Douglass L, Stafstrom C, Jara H, Frazier J, Hirtz D, Rollins J, Paneth N, Investigators E, Ware J, Coster T, Hanson B, Wilson R, McGhee K, Lee P, Asgarian A, Sadhwani A, Perrin E, Neger E, Mattern K, Walkowiak J, Barron S, Shah B, Singh R, Smith A, Klein D, McQuiston S, Venuti L, Powers B, Foley A, Dessureau B, Wood M, Damon-Minow J, Ehrenkranz R, Benjamin J, Romano E, Tsatsanis K, Chawarska K, Kim S, Dieterich S, Bearrs K, Peters N, Brown P, Ansusinha E, Waldrep E, Friedman J, Hounshell G, Allred D, Engelke S, Darden-Saad N, Stainback G, Warner D, Wereszczak J, Bernhardt J, McKeeman J, Meyer E, Pastyrnak S, Rathbun J, Nota S, Crumb T, Lenski M, Weiland D, Lloyd M, Hunter S, Msall M, Ramoskaite R, Wiggins S, Washington K, Martin R, Prendergast B, Scott M, Klarr J, Kring B, DeRidder J, Vogt K. Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm. Pediatric Neurology 2017, 79: 45-52. PMID: 29310907, PMCID: PMC5803305, DOI: 10.1016/j.pediatrneurol.2017.11.002.Peer-Reviewed Original ResearchConceptsCerebral palsyAge ten yearsNeurodevelopmental impairmentCognitive impairmentProspective cohort followAutism spectrum disorderMajor neurodevelopmental impairmentPercent of childrenThird of childrenQuarter of childrenCategory ICohort followGestational ageTen yearsNumber of impairmentsChildren BornImpairment severityMultiple diagnosesIII childrenEpilepsyNormal intellectImpairmentDiagnosisCategory IIITen-year-old childrenTemperamental markers in toddlers with autism spectrum disorder
Macari SL, Koller J, Campbell DJ, Chawarska K. Temperamental markers in toddlers with autism spectrum disorder. Journal Of Child Psychology And Psychiatry 2017, 58: 819-828. PMID: 28317113, PMCID: PMC5747932, DOI: 10.1111/jcpp.12710.Peer-Reviewed Original ResearchMeSH KeywordsAutism Spectrum DisorderChild, PreschoolDevelopmental DisabilitiesEmotionsExecutive FunctionFemaleHumansInfantMaleSelf-ControlSeverity of Illness IndexSocial SkillsTemperamentConceptsAutism spectrum disorderTemperamental vulnerabilitySpectrum disorderSocial outcomesLow-intensity pleasureCore autism symptomsAutism symptom severityGreater negative emotionalitySocial skill levelsNonverbal abilityPerceptual sensitivityTD peersASD groupAffective reactivityAutism symptomsAutism severityIndividual differencesNegative emotionalityTD groupInhibitory controlTemperamental characteristicsDevelopmental levelTime 2Childhood psychopathologyASD phenotype
2010
Limited Attentional Bias for Faces in Toddlers With Autism Spectrum Disorders
Chawarska K, Volkmar F, Klin A. Limited Attentional Bias for Faces in Toddlers With Autism Spectrum Disorders. JAMA Psychiatry 2010, 67: 178-185. PMID: 20124117, PMCID: PMC4871149, DOI: 10.1001/archgenpsychiatry.2009.194.Peer-Reviewed Original ResearchConceptsAttention disengagementVisual attentionRelevant stimuliDeep processingFace-processing difficultiesPoor face recognitionFace processing deficitsDisengagement of attentionCentral fixation stimulusAutism spectrum disorderSaccadic reaction timesBetween-groups factorAttentional biasSocial cognitionAttention taskAttentional mechanismsNonfacial stimuliAttentional levelStimulus typeSpectrum disorderTypical individualsReactive saccadesFixation stimulusASDGeneralized impairment
2008
Language outcomes of toddlers with autism spectrum disorders: a two year follow‐up
Paul R, Chawarska K, Cicchetti D, Volkmar F. Language outcomes of toddlers with autism spectrum disorders: a two year follow‐up. Autism Research 2008, 1: 97-107. PMID: 19360656, PMCID: PMC2946084, DOI: 10.1002/aur.12.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNonverbal IQLanguage outcomesSpectrum disorderEL outcomesDiagnosis of ASDJoint attention bidsExpressive language outcomesReceptive language scoresExpressive communication skillsNonverbal scoresLanguage scoresAutistic symptomsCognitive levelRepetitive behaviorsAge fourCommunication scoresNumber of soundsCommunication skillsSignificant predictionPlay schemesIQSecond yearStandard measuresOutcome group
2006
Parental Recognition of Developmental Problems in Toddlers with Autism Spectrum Disorders
Chawarska K, Paul R, Klin A, Hannigen S, Dichtel LE, Volkmar F. Parental Recognition of Developmental Problems in Toddlers with Autism Spectrum Disorders. Journal Of Autism And Developmental Disorders 2006, 37: 62-72. PMID: 17195921, DOI: 10.1007/s10803-006-0330-8.Peer-Reviewed Original Research