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In-Hyun Park, PhD

Associate Professor of Genetics and Associate Professor in the Child Study Center; Yale Stem Cell Center

Contact Information

In-Hyun Park, PhD

Lab Location

  • Amistad Street Building
    10 Amistad Street, Ste 214J
    New Haven, CT, 06519

Mailing Address

  • Genetics

    10 Amistad 201B

    New Haven, CT, 06520

    United States

Research Summary

Overexpression of four factors (Oct4, Sox2, Klf4, Myc, or Oct4, Sox2, Nanog, Lin28) reprogram somatic cells to become induced pluripotent stem (iPS) cells. Reprogramming accompanies genetic and epigenetic changes, and its molecular mechanism is still unknown. We recently showed that in iPS cells the global DNA methylation status is close to that of human embryonic stem (hES) cells, suggesting the epigenetic resetting during reprogramming. Furthermore, we have showed the possible dissection of stages in reprogramming through live cell imaging analysis.
We will investigate the molecular mechanism of genetic and epigenetic change during reprogramming. iPS cells show similar characteristics as hES cells, such as self-renewal and pluripotency, and provide an incredible resource for cell-based therapy, in vitro disease model and screening drugs.

Extensive Research Description

  • Investigation of genetic and epigenetic regulation of reprogramming
  • in vitro model of human neurodevelopmental disease

Research Interests

Cells; Central Nervous System Diseases; Nervous System; Stem Cells; Pluripotent Stem Cells; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Neural Stem Cells; Psychiatry and Psychology

Selected Publications