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Clinical Investigation (MHS-CI) Track

The Master of Health Science in Clinical Investigation (MHS-CI) program is dedicated to training the next generation of multidisciplinary clinicians, physician-scientists, and researchers in clinical investigation. The program emphasizes the importance of translating and reverse-translating research findings to address critical health issues and optimize patient care. A key aspect of the program is fostering strong mentor-mentee relationships and promoting collaboration between scientists and clinicians. The program actively encourages female and underrepresented individuals to pursue careers in clinical investigation and translational research.

Students in the MHS-CI program will develop a range of essential skills, including in-depth research methodology, hypothesis-driven research projects, clinical science, molecular genomic pathology in precision medicine, and pragmatic trial design and implementation. Additionally, the program focuses on building leadership skills that will enable graduates to excel in their careers and make meaningful contributions to the field of clinical investigation. The program spans two academic years, including two summers, and requires a minimum of 30 credits for completion.

A significant component of the MHS-CI program is the thesis research project. Each student is required to complete this project and submit a master’s thesis document before graduation. The thesis committee, composed of three faculty members, provides oversight, with the primary advisor offering broad clinical and translational guidance.

Upon entry into the MHS-CI program, each student works with the MHS-CI leadership and their thesis committee to design an Individual Learning Plan (ILP). The ILP is tailored to the student’s background, research interests, career goals, and the guidance of their mentor. This plan is a dynamic process, involving continuous evaluation and updates as needed. The ILP identifies a research project, establishes a laboratory or clinical environment, sets expectations and timelines, and provides guidance to help the student achieve their professional goals. The students are required to meet with their thesis committee semiannually to discuss their ILP.

The MHS-CI program is committed to producing graduates who are well-equipped to drive advancements in biomedical research and enhance patient care. Through rigorous academic and professional standards, the program aims to cultivate a diverse and dynamic learning environment that supports innovative research and meaningful contributions to the field of clinical investigation.

Program Goals

  • Train next generation, multidisciplinary clinicians, physician-scientists, and scientists in clinical investigation.
  • Translate and reverse-translate findings to bring solutions to diseases and provide optimal care for patients.
  • Support the mentor-mentee relationship and enhance collaborative environment between scientists and clinicians.
  • Encourage female and under-represented individuals to pursue careers in clinical investigation and translational research.

Program Benefits:

  • Transform and deliver cutting-edge care
  • Create multi-disciplinary collaborations
  • Translate discoveries into practice effectively
  • Strengthen evidence-based practice
  • Advance medicine
  • Improve healthcare equity
  • Increase leaders in patient care
  • Increase patient satisfaction, lower patient costs

Students will have MHS-CI specific skills including:

  • In-depth research methodology
  • Hypothesis-driven research projects
  • Clinical science skills
  • Molecular genomic pathology in precision medicine
  • Pragmatic trial design and implementation
  • Leadership

Course & Graduation Requirements

Degree will receive upon finish: Master of Health Science in Clinical Investigation

Program length: 2 academic years (fall + spring) + 2 summers

Credit requirement: ≥ 30 credits

Table: Outline of COURSEWORK
Courses
Year 1
Year 2
Summer
Fall
Spring
Summer
Fall
Spring
Required
HSCI 9100
(3 credits)
Molecular Genomic Pathology in Precision Medicine
X
HSCI 9200
(3 credits)
Pragmatic Trial Design and Implementation
X
HSCI 9300
(4 credits total)
MHS-CI Seminar Series
(1 credit/semester)
X
X
X
X
HSCI 3333
(3 credits)
Mentored Thesis Research Project
(2 credits/semester)
X
HSCI 2222
(8 credits total)
Mentored Thesis Research Project
(2 credits/semester)
X
X
X
X
HSCI 4444
(4 credits)
Mentored Thesis Research Project
(4 credits/semester)
X
HSCI 6450
(IMED645)
(2 credits)
Introduction to Biostatistics in Clinical Investigation
X
HSCI 6300
(IMED 630)
(1.5 credits)
Ethical Issues in Biomedical Research
(waived if taken within the last 5 years)
X
Electives: choose the suggested elective(s) that align with your research goals
EPH508a
(3 credits)
Foundations of Epidemiology and Public Health Epidemiology
(either Year 1 or Year 2)
X
X
IMED 665
(3 credits)
Writing your K or R Type Grant Proposal
(either Year 1 or Year 2)
X
X
IBIO 531
(3 credits)
Advanced Immunology
(either Year 1 or Year 2)
X
X
PHAR 504a
(3 credits)
Molecular Mechanisms of Drug Actions
(either Year 1 or Year 2)
X
X
IMED 680
(3 credits)
Topics in Human Investigation
(either Year 1 or Year 2)
X
X
BIS 568b
(3 credits)
Applied Artificial Intelligence in Healthcare
(either Year 1 or Year 2)
X
X

Time Allowance & Department Commitment

This is a two-year program that requires a 50-75% time commitment. For Yale applicants, approval from your department chair or division chief, in writing, is mandatory. If a participant is unable to complete the degree within two years, an extension must be approved by the Yale MHS Degree Program and the Track Academic Director.

Contact Us & Track Leadership

Clinical Investigation (MHS-CI) Track

  • Ensign Professor of Medicine (Medical Oncology) and Professor of Pharmacology; Deputy Director, Yale Cancer Center; Chief of Hematology/Medical Oncology, Yale Cancer Center and Smilow Cancer Hospital; Assistant Dean for Translational Research, Yale School of Medicine; Program Director, Master of Health Science - Clinical Investigation Track (MHS-CI)

Internal applicants