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Pathology Research Laboratories

Demetrios Braddock Laboratory. In the Braddock Laboratory, we study the pathophysiology of benign and malignant hematologic disorders using biochemical and biophysical methods.
Karin Finberg Laboratory. In the Finberg Laboratory, we use genetic approaches to investigate mechanisms that regulate systemic iron balance in normal physiology and to understand how disruption of these mechanisms contributes to the pathogenesis of clinical disorders of iron metabolism.

Pallavi Gopal Laboratory. The Gopal Laboratory studies mRNA transport, RNA metabolism and its regulation in healthy and diseased neurons, in order to identify therapeutic targets for neurodegenerative diseases such as Alzheimer’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis.

Samuel Katz Laboratory. The goal of the Katz Laboratory is to selectively control the cell death machinery for therapeutic benefit. We use a multidisciplinary approach to study select pro-apoptotic BCL-2 family proteins.
Steven Kleinstein Laboratory. The Kleinstein Laboratory is a computational immunology lab. Our work combines techniques from dynamic modeling, systems biology and bioinformatics to better understand the immune response.
Yuval Kluger Laboratory. The Kluger Laboratory concentrates on developing computational methodologies for analyzing high throughput biomedical data.
Themis Kyriakides Laboratory. The Kyriakides Laboratory is focused on elucidating the mechanism through which the endogenous inhibitor of angiogenesis TSP-2 limits angiogenesis and arteriogenesis.
Morgan Levine Laboratory. Research in the Morgan Levine Laboratory focuses on modeling epigenetic changes in aging. To do this, we use data from human and rodent cell culture and primary tissue samples to probe the causes and consequences of aging-related alterations in DNA methylation. We are also actively involved in the development of biomarkers of aging.
Zachary Levine Laboratory. In the Zachary Levine Laboratory, we seek to understand and intervene in human degenerative diseases using a wide variety of theoretical and experimental techniques. In particular, we work to understand protein aggregation diseases from a biophysical perspective.
Chen Liu Laboratory. The focus of the research in the Chen Liu Laboratory is on understanding of virus or alcohol-induced carcinogenesis, cancer biomarker discovery and novel therapies using small molecules and immunotherapy.
Joe Madri Laboratory. In the Madri Laboratory, we investigate neural stem cell responses to injury and roles of cell-cell and cell-ECM molecules in repair.
Wang Min Laboratory. The Min Laboratory has extensively employed biochemical, cell biological and mouse genetic approaches to define the critical molecules mediating vascular development, remodeling and repair related to human diseases such as vascular malformation, stroke, atherosclerosis, graft transplant rejection and tumor metastasis.
Gilbert Moeckel Laboratory. The research focus of the Moeckel Laboratory is in acute tubular injury (ATI) repair and progression of acute kidney injury (AKI) to chronic kidney disease (CKD). We are especially interested how interstitial cells facilitate tubular epithelial cell survival and prevent CKD.
Jon Morrow Laboratory. The Morrow Laboratory focuses our studies on understanding the principles of cell membrane biogenesis and order. Specifically, we investigate the mechanisms of the spectrin-based scaffold in hematological and neurological disease.
Don Nguyen Laboratory. The Nguyen Laboratory does investigation in the following areas: Metastasis; Tissue development; Lung cancer; Cancer genomics; Tumor microenvironment.
Katerina Politi Laboratory. In the Politi Laboratory, we study mechanisms of lung tumorigenesis and in particular, the molecular features of tumors that determine response and resistance to targeted drugs.
David Rimm Laboratory. In the Rimm Laboratory, we study the development and use of quantitative approaches to pathology and assay development to classify tumors or predict invasion, metastasis or response to cancer therapy
John Rose Laboratory. The Rose Laboratory focuses on developing new approaches to vaccines that will provide long-term protection against viral and bacterial diseases.
Kurt Schalper Laboratory. The Schalper Laboratory focuses on defining novel predictive biomarkers to identify responders and non-responders among patients who are being treated with immunotherapy for lung cancer.
Jeffrey Sklar Laboratory. Research in the Sklar Laboratory generally concerns the molecular biology of human disease, particularly in the areas of the molecular genetics of cancer, lymphocyte biology, endometrial function, and the development of molecular methods for disease diagnosis. The research is of both a basic and translational nature.
David F. Stern Laboratory. The Stern Laboratory investigates the cancer-causing processes of genetic and epigenetic changes that alter hormone-regulated signal transduction pathways, leading to growth dysregulation, and that alter protective responses to DNA damage, leading to genomic instability.
Qin Yan Laboratory. The Yan Laboratory studies cancer epigenetics and stem cell biology. We are interested in understanding how epigenetic aberrations cause cancer and other human diseases. In particular, we focus on the roles and regulatory mechanisms of histone demethylases from the JARID1/KDM5 protein family.