Yale Genitourinary

Genitourinary Pathology

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Tissue diagnosis by a subspecialty group of expert genitourinary pathologists, with a focus on genitourinary malignancies, including kidney cancer, bladder cancer, prostate cancer, and testicular cancer.  

Genitourinary Service

The Genitourinary Pathology service provides subspecialty expertise in tissue-based diagnosis of diseases of the kidney, bladder, prostate, and testis, especially malignancies that arise at these sites.  The seven attending genitourinary pathologists who cover the service are highly experienced and have worked closely together for many years.  Standardization and uniformity of diagnostic approaches and terminology are assured by close and regular interactions amongst the seven attendings and through a daily genitourinary pathology consensus conference.  We render diagnoses on tissues submitted from Yale New Haven Hospital and on slide consultations from physicians and hospitals in Connecticut and around the United States.  The Genitourinary Pathology service has a national and international presence in the pathology community.  

Services and Expertise

The Genitourinary Pathology service has daily diagnostic sessions at a dedicated multi-headed microscope in Surgical Pathology at Yale New Haven Hospital.   These sign-outs are directed by one of the attending genitourinary pathologists.  We also have a renal/genitourinary pathology fellow and pathology resident working with the attending on the service.  The service renders diagnoses on all genitourinary tissues submitted to the Yale Pathology Department and also on all genitourinary slide referrals and consultations.  Our diagnostic reports represent state-of-the-art diagnostic reporting, using national and international guidelines (such as those in the World Health Organization book on Classification of Tumors of the Urinary System and Male Genital Organs, and The College of American Pathologists Cancer Protocols) that we helped establish.   

Director

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Peter A Humphrey, MD, PhD

Professor of Pathology

Director, Genitourinary Pathology

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Pathologists

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Adebowale Adeniran, MD

Associate Professor of Pathology

Director of Cytopathology

Director, Cytology Laboratory

Director, Anatomic Pathology Elective

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Guoping Cai, MD

Associate Professor of Pathology

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Paul Jay Cohen, MD

Assistant Professor of Pathology

Chair, Bridgeport Hospital Pathology

Site Director, Yale Pathology Residency Program at Bridgeport Hospital

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Robert Homer, MD, PhD

Professor of Pathology

Director, Thoracic Pathology

Director of Medical Studies

Director, Medical Student Course Module

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Angelique W. Levi, MD

Associate Professor of Pathology

Director, Pathology Outreach

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John Sinard, MD, PhD

Professor of Pathology and of Ophthalmology and Visual Science

Vice Chair Pathology

Director, Anatomic Pathology

Medical Director, Pathology Informatics

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Research

The academic interests of the genitourinary pathologists are many, and include diagnostic criteria for genitourinary malignancies, correlative radiology (multiparametric MRI)–pathology studies, and molecular genetics of prostate and kidney cancer and their precursors.

Publications (selected recent):

  • Fu L, Hwang M, Adeniran AJ, Humphrey PA.  Proliferation index of different Gleason pattern 4 histomorphologies and associated pattern 3 adenocarcinoma of the prostate.  Hum Pathol 2017 Jun 27; Epub ahead of print. PMID: 28666926
  • Humphrey PA. Histopathology of prostate cancer.  Cold Spring Harb Perspect Med 2017 Apr 7; Epub ahead of print.  PMID : 28389514
  • Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE.  The 2016 WHO Classification of Tumours of the Urinary  System and Male Genital Organs – Part B. Prostate and bladder tumours.  Eur Urol 70:106-119, 2016.  PMID: 26996659
  • Alomari, Nettey OS, Singh D, Kluger H, Adeniran AJ.  Clinicopathological and immunohistochemical characteristics of papillary renal cell carcinoma with emphasis on subtyping.  Hum Pathol 46:1418-1426, 2015. PMID: 26239624
  • Adeniran AJ, Shuch B, Humphrey PA.  Hereditary renal cell carcinoma syndromes: Clinical, pathologic, and genetic features.  Am J Surg Pathol 139:e1-e18, 2015. PMID: 26559379

Education and Training

Genitourinary Pathology Faculty are engaged in numerous educational and teaching activities:

  • Yale School of Medicine : Course developer and lab leader on male genital malignancies in Beyond the Lifespan Medical Student Course
  • Urology Department : Monthly teaching sessions on Genitourinary Pathology are provided for Urology residents and fellows.
  • Pathology Department : Numerous lectures for pathology residents and fellows covering prostate cancer, mimics of prostate cancer, bladder cancer, testis cancer, and kidney cancer